Cardiac Markers

by Alan H. B. Wu (Editor)

Overview

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Product Details

ISBN-13:	9780896034341
Publisher:	Springer-Verlag New York, LLC
Publication date:	07/02/1998
Series:	Pathology and Laboratory Medicine , #3
Edition description:	1998
Pages:	302
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

	Foreword	viii
	Preface	xi
	Contributors	xv
Part I.	Cardiac Markers in Clinical Practice
1	Early Detection of Myocardial Necrosis in the Emergency Setting and Utility of Serum Biomarkers in Chest Pain Unit Protocols	3
2	Management of Acute Coronary Syndromes	15
3	Evolution of Cardiac Markers in Clinical Trials	37
4	Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers: Practice and Promise	59
5	The Use of Cardiac Biomarkers to Detect Myocardial Damage Induced by Chemotherapeutic Agents	87
6	The Use of Biomarkers to Provide Diagnostic and Prognostic Information Following Cardiac Surgery	111
Part II.	Clinical Use for Cardiac Troponins
7	Cardiac Troponins: Exploiting the Diagnostic Potential of Disease-Induced Protein Modifications	125
8	Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients	139
9	Cardiac-Specific Troponins Beyond Ischemic Heart Disease	149
Part III.	Analytical Issues for Cardiac Markers
10	Antibody Selection Strategies in Cardiac Troponin Assays	173
11	Interferences in Immunoassays for Cardiac Troponin	187
12	Cardiac Marker Measurement by Point-of-Care Testing	199
13	Standardization of Cardiac Markers	213
14	Analytical Issues and the Evolution of Cutoff Concentrations for Cardiac Markers	231
Part IV.	Early Cardiac Markers of Myocardial Ischemia and Risk Stratification
15	Rationale for the Early Clinical Application of Markers of Ischemia in Patients with Suspected Acute Coronary Syndromes	245
16	Ischemia-Modified Albumin, Free Fatty Acids, Whole Blood Choline, B-Type Natriuretic Peptide, Glycogen Phosphorylase BB, and Cardiac Troponin	259
17	C-Reactive Protein for Primary Risk Assessment	279
18	Prognostic Role of Plasma High-Sensitivity C-Reactive Protein Levels in Acute Coronary Syndromes	291
19	Preanalytic and Analytic Sources of Variations in C-Reactive Protein Measurement	305
20	Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification	319
21	Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein in Patients with Coronary Artery Disease	339
Part V.	Cardiac Markers of Congestive Heart Failure
22	Pathophysiology of Heart Failure	351
23	B-Type Natriuretic Peptide: Biochemistry and Measurement	369
24	B-Type Natriuretic Peptide in the Diagnoses and Management of Congestive Heart Failure	379
25	Monitoring Efficacy of Treatment with Brain Natriuretic Peptide	397
26	N-Terminal Pro-B-Type Natriuretic Peptide	411
Part VI.	Role of Infectious Diseases and Genetics in Heart Disease
27	Infectious Diseases in the Etiology of Atherosclerosis and Acute Coronary Syndromes: Focus on Chlamydia pneumoniae	427
28	Polymorphisms Related to Acute Coronary Syndromes and Heart Failure: Potential Targets for Pharmacogenomics	439
	Index	461

Editorial Reviews

"...addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine

"...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal

"This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International

From the Publisher

The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the bookshelves of clinical pathologists, emergency physicians, and cardiologists.

New England Journal of Medicine

This text primarily describes both current and possible future diagnostic laboratory tests for the assessment of patients potentially suffering from coronary artery disease, as well as how these procedures should be used in a clinical setting. The purpose is to provide the latest knowledge concerning the pathophysiology of acute coronary syndromes, the spectrum of clinical laboratory tests available for effective assessment, and the practical considerations in the use of, and clinical applications for, these cardiac marker procedures. The primary target audiences are practicing clinical laboratorians and clinical practitioners (particularly those in cardiology, emergency medicine, and general medicine). A secondary target audience would be students in laboratory medicine at a relatively advanced level (e.g., pathology residents and fellows). The content and format of this text are straightforward. Chapters are grouped into subdivisions on general clinical considerations in this area of cardiology, the current list of cardiac markers available for laboratory assessment (both cytoplasmic and structural), and the format/potential for future testing approaches (particularly those employing point-of-care testing applications). End of chapter reference lists are comprehensive, current, and highly pertinent. The index is useful, the format is logical, and the text is adequately illustrated with many practical figures and tables. This is a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application. The editor effectively combines fundamental clinical information and concerns with the appropriate practicalconsiderations in the use of a wide variety of laboratory test procedures relevant to this area. Laboratory practitioners may find this text more valuable than clinical practitioners due to the wealth of practical information provided about numerous analytical approaches which may not be of great interest to the clinician. Still, this book is highly recommended for any individual interested in the state-of-the-art of the appropriate laboratory assessment of the acute coronary syndrome patient.

Stephen E. Kahn

To help keep pace with the burgeoning knowledge base in cardiology, 17 papers detail the biochemical markers clinical laboratories use to aid in the earliest possible diagnosis and treatment of coronary artery diseases. Several contributors discuss the clinical aspects of CAD; specific cytoplasmic markers are addressed in six papers; and information on structural markers occupies others. Future trends in markers and point-of-care testing are considered in the concluding part. Other noteworthy features include a listing of commercial methodologies for all cardiac markers, and a description of their application in clinical settings in a cost- effective manner. Annotation c. by Book News, Inc., Portland, Or.

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