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Cardiovascular Biology of Purines
     

Cardiovascular Biology of Purines

by Geoffrey Burnstock (Editor)
 

Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. In this book we focus on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions.

Overview

Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. In this book we focus on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions. Activation of different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated responses both pre- and post-junctionally, trigger and mediate ischaemic preconditioning, cause vasodilation and vasoconstriction and enhance endothelial proliferation and apoptosis as well as inhibit platelet and neutrophil function. This book covers the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasizes the interactions between these two signalling systems.
Cardiovascular Biology of Purines covers topics ranging from molecular and cellular to systemic and clinical. It also aims to highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments. We hope that our book will prove to be timely and helpful.

Editorial Reviews

Booknews
Twenty-one contributions focus on the actions of purines in cardiovascular biology in both normal and pathophysiological conditions. They address the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasize the interactions between these two systems. Topics include adenosine and cardiac aging; vascular P2 receptors and their possible role in hypertension; purinoreceptors and T Cell function; recent advances in cardiac adenosine metabolism; and extracellular metabolism of nucleotides and adenosine in the cardiovascular system. Contributors highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments. Annotation c. by Book News, Inc., Portland, Or.

Product Details

ISBN-13:
9781461375630
Publisher:
Springer US
Publication date:
12/31/2012
Series:
Developments in Cardiovascular Medicine Series , #209
Edition description:
Softcover reprint of the original 1st ed. 1998
Pages:
374
Product dimensions:
6.14(w) x 9.21(h) x 0.81(d)

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