Cardiovascular Biomarkers: Pathophysiology and Disease Management / Edition 1

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Internationally recognized opinion makers and experts in clinical and laboratory medicine synthesize the latest developments in the use of cardiac biomarkers by the practicing physician. The authors focus on integrating biomarkers into the contemporary clinical management of patients with cardiovascular disease, emphasizing clinical studies, evidence-based diagnostic algorithms, and critical pathways for triage and therapy, whenever available. They also illuminate the connections between specific biomarkers and the basic pathophysiology of cardiovascular disease, explain the analytical properties of the assays relevant to clinical practice, and highlight emerging novel biomarkers and new direction for biomarker development. Numerous figures, illustrations, and tables make key evidence and practical guidelines easily accessible. The book makes clear as never before to today's busy cardiologists, emergency room physicians, and internists how the various assays perform, which ones they should order to evaluate their patients, and how they might change their therapeutic approach based on the results of a biomarker assay.

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Editorial Reviews

Doody's Review Service
Reviewer: Cooper Woods, Ph.D.(Ochsner Clinic Foundation)
Description: This book provides a clear presentation of the use of biomarkers in the diagnosis and treatment of cardiovascular diseases. Especially appealing is the format which divides the biomarkers into seven classes, introducing the biological background for each class and then examining the individual members of the class more closely.
Purpose: The author seeks to provide clinicians with an authoritative book on the current state-of-the art in cardiovascular biomarkers. The book provides background on the reasons behind the development of the current biomarkers in a logical format that makes the material easily accessible.
Audience: It is aimed at practicing cardiologists and does an excellent job of defining the development and use of the current set of cardiovascular biomarkers as well as providing insight into the future directions of the field. A clear strength of the book is that the author has pulled together a first-class team of authors to present a complicated and diverse field in a well structured and comprehensible style.
Features: The book has broken down the current set of cardiovascular biomarkers into seven major classes. This format makes the material accessible while covering very diverse areas of biology. Strengths of the book include the chapters on necrosis, inflammation, and hemodynamic stress where a thorough analysis of the currently used biomarkers is presented. The chapters on ischemia, hemostasis, and dyslipidemia provide insight into the potential future role of biomarkers in these areas. A final chapter provides an overview of the methods used to develop cardiovascular biomarkers.
Assessment: This book presents a complicated subject in a well organized and thorough manner, providing the clinician with valuable insight into the development of the biomarkers currently in use and the future directions of the field.
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Product Details

  • ISBN-13: 9781588295262
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/28/2006
  • Series: Contemporary Cardiology Series
  • Edition description: 2006
  • Edition number: 1
  • Pages: 640
  • Product dimensions: 7.30 (w) x 10.20 (h) x 1.10 (d)

Table of Contents

1 Biomarkers of myocardial necrosis : past, present, and future 3
2 Analytical issues for the clinical use of cardiac troponin 27
3 Defining myocardial infarction 41
4 Biomarkers in the emergency department : rapid diagnosis and triage 61
5 Cardiac troponin for risk assessment and management of non-ST-elevation acute coronary syndrome 79
6 Biomarkers of necrosis for risk assessment and management of ST-elevation myocardial infarction 93
7 Cardiac troponin after revascularization procedures 103
8 Biomarkers of necrosis in heart failure : past, present, and future directions 119
9 Is there a role for cardiac troponin and other biomarkers in patients with pulmonary embolism? 129
10 Cardiac troponin in conditions other than acute coronary syndromes 139
11 Degradation of cardiac troponins : implications for clinical practice 161
12 Developing a marker of ischemia : clinical and research challenges 177
13 Emerging biomarkers of myocardial ischemia 193
14 Inflammation in cardiovascular disease : the biological basis of inflammatory biomarkers 207
15 Analytic issues for the clinical use of C-reactive protein 223
16 C-reactive protein as a tool for risk assessment in primary prevention 237
17 High-sensitivity C-reactive protein for risk assessment in acute coronary syndromes 261
18 Beyond C-reactive protein : novel markers of vascular inflammation 277
19 Biomarkers of inflammation : implications in patients with heart failure 295
20 Biomarkers of infection and risk of coronary heart disease 319
21 Biology of the natriuretic peptides 347
22 Analytic issues for the clinical use of B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide 373
23 Clinical use of natriuretic peptides for the diagnosis and management of heart failure 387
24 Natriuretic peptides in acute and chronic coronary artery disease 409
25 Novel markers of hemodynamic stress 427
26 Clinical and research applications of markers of thrombosis 451
27 Measures of platelet activation and aggregation 467
28 Monocyte-platelet aggregates in patients with ischemic heart disease 487
29 Measurement of atherogenic lipoproteins in cardiovascular risk assessment 497
30 Lipoprotein-associated phospholipase A[subscript 2] and other lipid-related biomarkers in cardiovascular disease 519
31 A multimarker approach to evaluation of patients with acute coronary syndrome 545
32 Cardiac biomarkers by point-of-care testing 559
33 Proteomics and cardiovascular biomarker discovery 575
34 Genetic markers in cardiovascular disease 587
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