Cardiovascular Biomarkers: Pathophysiology and Disease Management

Overview

Internationally recognized opinion makers and experts in clinical and laboratory medicine synthesize the latest developments in the use of cardiac biomarkers by the practicing physician. The authors focus on integrating biomarkers into the contemporary clinical management of patients with cardiovascular disease, emphasizing clinical studies, evidence-based diagnostic algorithms, and critical pathways for triage and therapy, whenever available. They also illuminate the connections between specific biomarkers and ...

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Overview

Internationally recognized opinion makers and experts in clinical and laboratory medicine synthesize the latest developments in the use of cardiac biomarkers by the practicing physician. The authors focus on integrating biomarkers into the contemporary clinical management of patients with cardiovascular disease, emphasizing clinical studies, evidence-based diagnostic algorithms, and critical pathways for triage and therapy, whenever available. They also illuminate the connections between specific biomarkers and the basic pathophysiology of cardiovascular disease, explain the analytical properties of the assays relevant to clinical practice, and highlight emerging novel biomarkers and new direction for biomarker development. Numerous figures, illustrations, and tables make key evidence and practical guidelines easily accessible. The book makes clear as never before to today's busy cardiologists, emergency room physicians, and internists how the various assays perform, which ones they should order to evaluate their patients, and how they might change their therapeutic approach based on the results of a biomarker assay.

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Editorial Reviews

Doody's Review Service
Reviewer: Cooper Woods, Ph.D.(Ochsner Clinic Foundation)
Description: This book provides a clear presentation of the use of biomarkers in the diagnosis and treatment of cardiovascular diseases. Especially appealing is the format which divides the biomarkers into seven classes, introducing the biological background for each class and then examining the individual members of the class more closely.
Purpose: The author seeks to provide clinicians with an authoritative book on the current state-of-the art in cardiovascular biomarkers. The book provides background on the reasons behind the development of the current biomarkers in a logical format that makes the material easily accessible.
Audience: It is aimed at practicing cardiologists and does an excellent job of defining the development and use of the current set of cardiovascular biomarkers as well as providing insight into the future directions of the field. A clear strength of the book is that the author has pulled together a first-class team of authors to present a complicated and diverse field in a well structured and comprehensible style.
Features: The book has broken down the current set of cardiovascular biomarkers into seven major classes. This format makes the material accessible while covering very diverse areas of biology. Strengths of the book include the chapters on necrosis, inflammation, and hemodynamic stress where a thorough analysis of the currently used biomarkers is presented. The chapters on ischemia, hemostasis, and dyslipidemia provide insight into the potential future role of biomarkers in these areas. A final chapter provides an overview of the methods used to develop cardiovascular biomarkers.
Assessment: This book presents a complicated subject in a well organized and thorough manner, providing the clinician with valuable insight into the development of the biomarkers currently in use and the future directions of the field.
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Product Details

  • ISBN-13: 9781617376207
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Contemporary Cardiology Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2006
  • Edition number: 1
  • Pages: 640
  • Product dimensions: 1.29 (w) x 7.00 (h) x 10.00 (d)

Table of Contents

Biomarkers of Necrosis.- Biomarkers of Myocardial Necrosis.- Analytical Issues for Clinical Use of Cardiac Troponin.- Defining Myocardial Infarction.- Biomarkers in the Emergency Department.- Cardiac Troponin for Risk Assessment and Management of Non-ST-Elevation Acute Coronary Syndrome.- Biomarkers of Necrosis for Risk Assessment and Management of ST-Elevation Myocardial Infarction.- Cardiac Troponin After Revascularization Procedures.- Biomarkers of Necrosis in Heart Failure.- Is There a Role for Cardiac Troponin and Other Biomarkers in Patients With Pulmonary Embolism?.- Cardiac Troponin in Conditions Other Than Acute Coronary Syndromes.- Degradation of Cardiac Troponins.- Biomarkers of Ischemia.- Developing a Marker of Ischemia.- Emerging Biomarkers of Myocardial Ischemia.- Biomarkers of Inflammation.- Inflammation in Cardiovascular Disease.- Analytic Issues for Clinical Use of C-Reactive Protein.- C-Reactive Protein as a Tool for Risk Assessment in Primary Prevention.- High-Sensitivity C-Reactive Protein for Risk Assessment in Acute Coronary Syndromes.- Beyond C-Reactive Protein.- Biomarkers of Inflammation.- Biomarkers of Infection and Risk of Coronary Heart Disease.- Biomarkers of Hemodynamic Stress.- Biology of Natriuretic Peptides.- Analytic Issues for Clinical Use of B-Type Natriuretic Peptide and N-Terminal Pro B-Type Natriuretic Peptide.- Clinical Use of Natriuretic Peptides for the Diagnosis and Management of Heart Failure.- Natriuretic Peptides in Acute and Chronic Coronary Artery Disease.- Novel Markers of Hemodynamic Stress.- Biomarkers of Platelet Function and Hemostasis.- Clinical and Research Applications of Markers of Thrombosis.- Measures of Platelet Activation and Aggregation.- Monocyte-Platelet Aggregates in Patients With Ischemic Heart Disease.- Biomarkers of Dyslipidemia and Lipid Modification.- Measurement of Atherogenic Lipoproteins in Cardiovascular Risk Assessment.- Lipoprotein-Associated Phospholipase A2 and Other Lipid-Related Biomarkers in Cardiovascular Disease.- Contemporary and Future Applications of Biomarkers in clinical care.- A Multimarker Approach to Evaluation of Patients With Acute Coronary Syndrome.- Cardiac Biomarkers by Point-of-Care Testing.- Proteomics and Discovery of Cardiovascular Biomarkers.- Genetic Markers in Cardiovascular Disease.

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