Cardiovascular Disease in AIDS / Edition 2

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Overview

The introduction of highly active antiretroviral therapy (HAART) has significantly improved the clinical outcome of HIV disease with increased survival rates. However, the introduction of HAART has generated a contrast in the cardiac manifestations of AIDS. In developed countries, we observed an approximate 30% reduction in the prevalence of HIV-associated cardiomyopathy, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availability of HAART is limited and the pathogenic impact of nutritional factors is significant, we observed an approximate 32% increase in the prevalence of HIV-associated cardiomyopathy and a related high mortality rate from congestive heart failure. Additionally, some HAART regimens in developed countries, especially those including protease inhibitors, may cause an iatrogenic metabolic syndrome (HIV-lipodystrophy syndrome) that is associated with an increased risk of cardiovascular disease. At the same time, the relapse of some opportunistic infections, with possible myocardial involvement, in HIV-infected patients receiving HAART, in the context of the recently described immune reconstitution inflammatory syndrome, yielded an intriguing and complex profile of this dual aspect of cardiology in AIDS in the HAART era. In this new edition of Cardiovascular Disease in AIDS, new insights coming from basic and clinical research in the field of HIV-associated cardiovascular disease and antiretroviral therapy are reported along with the clinical guidelines for a careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected patients receiving HAART. The authors offer a wide overview of the topic for specialists in cardiology and infectious diseases involved in the clinical management of HIV-infected patients.

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Editorial Reviews

Doody's Review Service
Reviewer: George T Deriso, MD (Ochsner Clinic Foundation)
Description: The editors have brought together experts in the field to create this well organized and comprehensive book on HIV-related cardiovascular disease.
Purpose: The purpose is to disseminate knowledge in the field so that healthcare professionals can pool their expertise and develop a successful management strategy for cardiovascular disease in HIV-infected patients.
Audience: The audience is primarily cardiovascular and infectious disease professionals, but the book is useful for any healthcare professionals involved in the care of HIV-infected individuals.
Features: The book covers previously described cardiovascular manifestations and complications of HIV infection, but the primary focus is on new clinical and biological insight related to HIV-associated metabolic and cardiovascular complications in the highly active antiretroviral therapy (HAART) era. Topics include peripheral, coronary, and cerebrovascular disease as well as cardiovascular complications, cardiac surgery, and guidelines for the prevention of cardiovascular risk in the HIV infected patient. The appendixes contain easy to use references for cardiovascular monitoring, risk stratification, primary prevention guidelines, and a drug interaction table between antiretroviral and commonly used cardiovascular agents. The book is full of well integrated and easy to follow graphs, tables, and figures, which include high quality photographs, color plates, radiographs, and echocardiograph images.
Assessment: The editors have succeeded in providing a comprehensive book on cardiovascular disease in the HIV infected patient. It will aid healthcare professionals involved in their care in recognition of pathology and formulation of treatment strategies in this complex patient population.
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Product Details

  • ISBN-13: 9788847007604
  • Publisher: Springer Milan
  • Publication date: 11/21/2008
  • Edition description: 2nd ed. 2009
  • Edition number: 2
  • Pages: 246
  • Product dimensions: 7.60 (w) x 10.60 (h) x 0.60 (d)

Table of Contents

Natural History of HIV Infection and Evolution of Antiretroviral Therapy.- Evolution and Pathogenesis of the Involvement of the Cardiovascular System in HIV Infection.- Pathogenesis of Antiretroviral Treatment-Associated Metabolic Syndrome.- Pathology of Cardiac Complications in HIV Infection.- Pathology of Peripheral and Coronary Vessels in AIDS Patients.- Echocardiographic Findings in HIV-Infected Patients.- Cardiac MRI in Diagnosis of Myocardial Disease in HIV-Infected Patients.- Coronary Heart Disease in HIV-Infected Patients: Epidemiology.- Coronary Artery Disease in HIV-Infected Patients: Clinical Presentation, Pathophysiology, Prognosis, Prevention and Treatment.- Cerebrovascular Disease in HIV-Infected Patients.- Peripheral Arterial Disease in HIV-Infected Patients: Atherosclerosis and Vasculitic Syndromes.- HIV-Associated Pulmonary Hypertension.- Coagulative Disorders in HIV-Infected Patients.- Cardiovascular Complications in HIV-Infected Children.- Cardiac Surgery and the Human Immunodeficiency Virus.- Cardiological Emergencies in HIV-Infected Patients.- Guidelines for the Prevention of Cardiovascular Risk in HIV-Infected Patients Treated with Antiretroviral Drugs.- Appendindix 1: Cardiovascular Monitoring of HIV-Infected Subjects and Cardiovascular Risk Stratification and Prevention of Cardiovascular Disease in Patients Receiving HAART.- Appendinx 2: Interactions Between Antiretrovirals and Drugs Commonly Used to Treat Cardiovascular Diseases.- Subject index.

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