Cardiovascular Genetics and Genomics / Edition 1

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This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.

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Editorial Reviews

From the Publisher
'This excellent book highlights the many advances in this field, and educates cardiovascular practitioners about what aspects of cardiology are likely to lend themselves to pharmacogenetics and tailored therapy.' (Doody's, 2009)
Doody's Review Service
Reviewer: Carlos D Giraldo, MD (Ochsner Clinic Foundation)
Description: This book explains the tools of modern genetics and genomics behind the bedside observations ingrained into generations of cardiovascular practitioners. A useful appendix provides simple definitions of the various concepts.
Purpose: It is designed to outline advances in gene discovery, and to describe how finding these genes might inform new approaches to practice while also raising new concerns. It is intended as an introduction to the basic principles, methodologies, and statistical issues, and how this new knowledge may be incorporated into practice. It also provides an overview of the state of the art of genetics and genomics as applied to cardiovascular diseases, including variability in drug responsiveness. These important objectives are met with concise, yet thorough explanations.
Audience: Cardiovascular practitioners are the primary audience, but the many expert authors have produced a book that has relevance for clinicians at all levels of training.
Features: The authors start with a detailed overview of the relevant statistical principles and methods. They then transition into clinical practice with a discussion of the genetics of thromboembolism and long QT syndrome, to name a few. The chapters further understanding of the genetics behind various disease states, including platelet function and arterial thrombosis and provide detailed discussions of pharmacogenetic medicine and tailored therapy.
Assessment: This excellent book highlights the many advances in this field, and educates cardiovascular practitioners about what aspects of cardiology are likely to lend themselves to pharmacogenetics and tailored therapy.
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Product Details

Meet the Author

Dan M. Roden, M.D., Professor of Medicine and Pharmacology, Director, Oates Institute for Experimental Therapeutics, Assistant Vice-Chancellor for Personalized Medicine, Vanderbilt University School of Medicine.

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Table of Contents

Provisional list of contents.

Section A: Principles.

1 Principles of genetics and genomics.

2 Candidate gene and genome-wide association approaches.

3 A primer in statistical methods in genetics.

4 Ethical, legal, and social issues.

5 The role of ethnicity in managing cardiovascular patients.

6 Moving to the bedside: When? How?.

Section B: Specific cardiovascular disease.

7 Genomics and Atrial Arrhythmias.

8 Ventricular arrhythmias and sudden death.

9 Hypertrophic Cardiomyopathy and Other Forms of Hypertrophy.

10 Genetics and genomics of dilated cardiomyopathy.

11 Arrhythmogenic Right Ventricular Cardiomyopathy.

12 Genetics of atherosclerosis.

13 Hypertension.

14 Stroke Genomics.

15 Thrombosis.

16 Case study: warfarin pharmacogenetics from single to multiple genes.

17 Pharmacogenetics and Pharmacogenomics.

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