Cardiovascular Genetics and Genomics for the Cardiologist / Edition 1

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Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.

In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand:
• how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
• what material has immediate relevance to the practicing clinician
• how to incorporate genetics and genomics in your practice to ensure up-to-date patient care

The book opens with introductory chapters, then discusses:
• cardiovascular single gene disorders
• cardiovascular polygenic disorders
• therapies and applications

Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

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Editorial Reviews

From the Publisher
"An excellent guide for developing, reviewing, or updating a keen understanding of genetics and its future in medicine. The book should find wide readership."
Doodys Review
Doody's Review Service
Reviewer: Emanuel D Chryssos, M.D.(Ochsner Clinic Foundation)
Description: This introductory book summarizes both common and rare disorders encountered in cardiology at the gene level. In addition, both current and future strategies for therapeutic intervention at the gene level are described.
Purpose: This is a much needed undertaking. A wide range of information concerns are addressed by leaders in the field and the book fulfills an important purpose as part of the armamentarium of knowledge a practicing cardiologist should possess. What further marks the book as important is how little most cardiologists know about genetics, yet how important it may soon be.
Audience: The modest background that most cardiologists have in genetics, while practicing in an environment that may soon be engulfed with gene therapy and gene modification, makes this book a necessity for them. In addition, it can be a concise review of various genetic diseases that can affect the cardiovascular system for the cardiologist who has a good understanding of genetics and genomics.
Features: The book illustrates the history of the concepts in genetics and genomics that have come about since the 1960s. It allows the reader to smoothly assimilate the language of genetics and genomics in their further reading. The format in the three sections that make up the book is very well done with numerous illustrations that facilitate understanding of the concepts. The single-gene disorders section discusses monogenic hypercholesterolemia, hypertrophic cardiomyopathy, and congenital long QT syndrome. Emphasis is placed on basic understanding of the mutation and how that mutation can be targeted for future therapeutic intervention. Several chapters discuss polygenic disorders, such as atherosclerosis, hypertension, and cardiomyopathy. The book concludes with several chapters on therapy, gene, stem cell, and pharmacogenomic. Lastly, pharmacogenetics and genomics introduces the concept of variance in response to drug therapy.
Assessment: This is an excellent guide for developing, reviewing, or updating a keen understanding of genetics and genomics and its future in medicine. The selection of topics and the depth with which they are covered fill a gap. The book should find wide readership.
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Product Details

  • ISBN-13: 9781405133944
  • Publisher: Wiley
  • Publication date: 7/1/2007
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 328
  • Product dimensions: 7.30 (w) x 10.30 (h) x 0.90 (d)

Meet the Author

Victor J. Dzau, MD
James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA

Choong-Chin Liew, PhD
Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

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Table of Contents




1 The gene in the twenty-first century.

Choong-Chin Liew, Victor J. Dzau.

Part I: Cardiovascular single gene disorders.

2 Monogenic hypercholesterolemia.

Ruth McPherson.

3 Hypertrophic cardiomyopathy.

Ali J. Marian.

4 Dilated cardiomyopathy and other cardiomyopathies.

Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.

5 The long QT syndrome.

Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima.

Part II: Cardiovascular polygenic disorders.

6 Atherosclerosis.

Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew.

7 Heart failure.

Markus Meyer, Peter VanBuren.

8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension.

Kiat Tsong Tan, Choong-Chin Liew.

Part III: Therapies and applications.

9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects.

Ion S. Jovin, Frank J. Giordano.

10 Stem cell therapy for cardiovascular disease.

Emerson C. Perin, Guilherme V. Silva.

11 Pharmacogenetics and personalized medicine.

Julie A. Johnson, Issam Zineh.

12 The potential of blood-based gene profiling for disease assessment.

Steve Mohr, Choong-Chin Liew.


Colour plates

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