Cardiovascular Genetics and Genomics for the Cardiologist / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$189.95
Buy Used
Buy Used from BN.com
$137.96
(Save 31%)
Item is in good condition but packaging may have signs of shelf wear/aging or torn packaging.
Condition: Used – Good details
Used and New from Other Sellers
Used and New from Other Sellers
from $46.31
Usually ships in 1-2 business days
(Save 76%)
Other sellers (Hardcover)
  • All (10) from $46.31   
  • New (5) from $171.73   
  • Used (5) from $46.31   

Overview

Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.

In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand:
• how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
• what material has immediate relevance to the practicing clinician
• how to incorporate genetics and genomics in your practice to ensure up-to-date patient care

The book opens with introductory chapters, then discusses:
• cardiovascular single gene disorders
• cardiovascular polygenic disorders
• therapies and applications

Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

Read More Show Less

Editorial Reviews

From the Publisher
"An excellent guide for developing, reviewing, or updating a keen understanding of genetics and its future in medicine. The book should find wide readership."
Doodys Review
Doody's Review Service
Reviewer: Emanuel D Chryssos, M.D.(Ochsner Clinic Foundation)
Description: This introductory book summarizes both common and rare disorders encountered in cardiology at the gene level. In addition, both current and future strategies for therapeutic intervention at the gene level are described.
Purpose: This is a much needed undertaking. A wide range of information concerns are addressed by leaders in the field and the book fulfills an important purpose as part of the armamentarium of knowledge a practicing cardiologist should possess. What further marks the book as important is how little most cardiologists know about genetics, yet how important it may soon be.
Audience: The modest background that most cardiologists have in genetics, while practicing in an environment that may soon be engulfed with gene therapy and gene modification, makes this book a necessity for them. In addition, it can be a concise review of various genetic diseases that can affect the cardiovascular system for the cardiologist who has a good understanding of genetics and genomics.
Features: The book illustrates the history of the concepts in genetics and genomics that have come about since the 1960s. It allows the reader to smoothly assimilate the language of genetics and genomics in their further reading. The format in the three sections that make up the book is very well done with numerous illustrations that facilitate understanding of the concepts. The single-gene disorders section discusses monogenic hypercholesterolemia, hypertrophic cardiomyopathy, and congenital long QT syndrome. Emphasis is placed on basic understanding of the mutation and how that mutation can be targeted for future therapeutic intervention. Several chapters discuss polygenic disorders, such as atherosclerosis, hypertension, and cardiomyopathy. The book concludes with several chapters on therapy, gene, stem cell, and pharmacogenomic. Lastly, pharmacogenetics and genomics introduces the concept of variance in response to drug therapy.
Assessment: This is an excellent guide for developing, reviewing, or updating a keen understanding of genetics and genomics and its future in medicine. The selection of topics and the depth with which they are covered fill a gap. The book should find wide readership.
Read More Show Less

Product Details

  • ISBN-13: 9781405133944
  • Publisher: Wiley
  • Publication date: 7/1/2007
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 328
  • Product dimensions: 7.30 (w) x 10.30 (h) x 0.90 (d)

Meet the Author

Victor J. Dzau, MD
James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA

Choong-Chin Liew, PhD
Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Read More Show Less

Table of Contents

Contributors.

Foreword.

Introduction.

1 The gene in the twenty-first century.

Choong-Chin Liew, Victor J. Dzau.

Part I: Cardiovascular single gene disorders.

2 Monogenic hypercholesterolemia.

Ruth McPherson.

3 Hypertrophic cardiomyopathy.

Ali J. Marian.

4 Dilated cardiomyopathy and other cardiomyopathies.

Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.

5 The long QT syndrome.

Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima.

Part II: Cardiovascular polygenic disorders.

6 Atherosclerosis.

Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew.

7 Heart failure.

Markus Meyer, Peter VanBuren.

8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension.

Kiat Tsong Tan, Choong-Chin Liew.

Part III: Therapies and applications.

9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects.

Ion S. Jovin, Frank J. Giordano.

10 Stem cell therapy for cardiovascular disease.

Emerson C. Perin, Guilherme V. Silva.

11 Pharmacogenetics and personalized medicine.

Julie A. Johnson, Issam Zineh.

12 The potential of blood-based gene profiling for disease assessment.

Steve Mohr, Choong-Chin Liew.

Index.

Colour plates

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)