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Doody's Review ServiceReviewer: Kerby C. Oberg, MD, PhD (Loma Linda University)
Description: This book couples an in-depth update on current techniques to evaluate cardiac physiology with an introduction to the molecular mechanisms used to engineer alterations in the mouse genome.
Purpose: Genetic alteration of cardiac-related genes in mice provides a powerful tool to unravel the mechanisms behind cardiac development, cardiac function, and the pathophysiology of cardiac disease. To fully appreciate the anatomic and physiologic effects of these genetically engineered mice, new and classical techniques of analysis must be employed.
Audience: This book is written for those facing the challenge of analyzing the cardiac sequelae of altering cardiac-related genes in mice. Although this might include molecular biologists attempting to analyze new mouse mutants developed in their laboratories, its language and focus target those whose primary discipline is physiology in general and cardiac physiology in particular (as the title indicates). For example, the early chapters introducing the molecular techniques employed in genetic engineering provide a well-written, but brief, overview for the classical physiologist or medical clinician who may not have any experience or training in molecular techniques. As physician-scientists who are well published in both scientific and clinical literature, both authors bring a unique bent toward translational medicine to the book
Features: The authors of this book attempt to provide a common resource for molecular biologists, physiologists, and to some extent cell biologists in an effort to enhance productivity in this field and encourage collaborative efforts. The book falls short of being comprehensive in that it fails to include any directed discussion about techniques or an approach to study potential morphologic subtleties of hearts from genetically engineered mice. That said, the book still provides a forum for integrating classical and molecular approaches.
Assessment: This book is a timely resource at a point in science where genetically engineered mice are being produced more rapidly than they can be analyzed. Although several symposia have focused on the pathology of genetically-engineered mice (GEM) including that of cardiovascular pathology, no book or symposium has targeted cardiac pathophysiology of the GEM with the depth that this book does. Furthermore, this second edition adds much needed introductory material including molecular techniques, cardiac development and cutting-edge technologies.