Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition / Edition 8

Hardcover (Print)
Rent from
(Save 75%)
Est. Return Date: 07/25/2015
Used and New from Other Sellers
Used and New from Other Sellers
from $76.41
Usually ships in 1-2 business days
(Save 49%)
Other sellers (Hardcover)
  • All (21) from $76.41   
  • New (12) from $103.44   
  • Used (9) from $76.41   


The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color

The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date,

revealing, and in-depth look at the systemic responses of toxic substance available anywhere.

Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references.

NEW to the Eighth Edition

  • FULL-COLOR design to allow for a clearer interpretation

    of the basic components of toxicology featured throughout the text

  • EXPANDED tables, illustrations, and other visuals are

    updated with state-of-the-art standards that makes this

    edition even more current and relevant

  • DVD with image bank features all tables and illustrations from the text in presentation-ready format
  • NEW CHAPTERS include "Toxic Effects of Calories"

    and "Toxic Effects of Nanoparticles"

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

Niko Keys
This is a new edition of a major textbook on the basic science of toxicology intended for both students and practitioners. Its emphasis is on mechanisms of toxicity. The last edition was published in 1991. It provides information on the many facets of toxicology, especially on the principles, concepts, and modes of thought that are the foundation of the discipline. This book is written for graduate courses in toxicology. In addition, scientists from other disciplines may find relevant sections. This is an accurate target audience, in my opinion. The illustrations are well done and absolutely necessary. The text is extensively referenced and up-to-date. The book is neat in appearance. This continues to be the premier reference book on the basic science of toxicology. The new edition is a timely update of a very useful book.
From The Critics
Reviewer: Kim A Anderson, PhD(Oregon State University)
Description: This 6th edition of a classic toxicology text picks up where the last edition left off, keeping all the fundamental pedagogically important components while adding current research toxicology. The addition of more risk assessment is an excellent enhancement to this edition. The previous edition was published in 1996.
Purpose: The purpose is to serve primarily as a text for graduate courses in toxicology. To this end the book hits the bulls-eye. Pedagogically, the book is a cornerstone to toxicology students. It is "must-have" for all students in toxicology or working in toxicologically related fields. The book meets the authors' objectives.
Audience: The authors have prepared the book for students in toxicology. It is also an excellent desk reference for researchers working in fields related to toxicology. The authors are all highly recognized in their fields.
Features: The book covers the basic components of toxicology, from general principles, modes of action, target organs, and chemical-specific toxicity. It concludes with environmental toxicology and applications of toxicology. The environmental toxicology chapter is composed of two sections covering air pollution and ecotoxicology. In the interest of keeping the book a manageable size, other areas of pollution may have been left out, but many users would not necessarily rank air pollution over other forms of pollution (water, etc.). In the application of toxicology chapter, the regulatory section could use a better description of quality control and quality assurance and how this integrates with good laboratory practices (GLP). Many toxicology students will work at some point on a GLP study. Most notably, the brief discussion is not well referenced so the students are not led to other sources of information.
Assessment: This book is now an established classic in the field of toxicology. In the time between the 5th and 6th edition, there have been significant advances in research that warrant this edition. When it comes to completeness, there really is no comparable book on the market. The down side is that the book now is getting so large than it may soon become impractical for students to carry it around to classes. An option that one might consider is to get the book on CD, since many students bring a computer to class as much or more than their books.
**** The fourth edition (1991, ed. by Mary O. Amdur et al.) is cited in Brandon-Hill. A text for, or an adjunct to, graduate courses in toxicology, providing information on the principles, concepts, and modes of thought that are the foundation of the discipline. The present edition is revised and updated to reflect the marked progress in toxicology during this decade. It adds three new chapters, on toxicokinetics, mechanisms of toxicity, and toxic responses of the endocrine system, as well as an appendix on recommended limits for exposure to chemicals. Annotation c. Book News, Inc., Portland, OR (

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780071769235
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 7/5/2013
  • Edition number: 8
  • Pages: 1454
  • Sales rank: 275,845
  • Product dimensions: 8.90 (w) x 11.00 (h) x 2.00 (d)

Meet the Author

Curtis Klaassen, PhD

Distinguished Professor and Chair

Department of Pharmacology, Toxicology, and Therapeutics

The University of Kansas

Read More Show Less

Table of Contents

Preface to the First Edition
Unit 1 General Principles of Toxicology
1 History and Scope of Toxicology
2 Principles of Toxicology
3 Mechanisms of Toxicity
4 Risk Assessment
Unit 2 Disposition of Toxicants
5 Absorption, Distribution, and Excretion to Toxicants
6 Biotransformation of Xenobiotics
7 Toxicokinetics
Unit 3 Non-Organ-Directed Toxicity
8 Chemical Carcinogenesis
9 Genetic Toxicology
10 Development Toxicology
Unit 4 Target Organ Toxicity
11 Toxic Responses of the Blood
12 Toxic Responses of the Immune System
13 Toxic Responses of the Liver
14 Toxic Responses of the Kidney
15 Toxic Responses of the Respiratory System
16 Toxic Responses of the Nervous System
17 Toxic Responses of the Ocular and Visual System
18 Toxic Responses of the Heart and Vascular Systems
19 Toxic Responses of the Skin
20 Toxic Responses of the Reproductive System
21 Toxic Responses of the Endocrine System
Unit 5 Toxic Agents
22 Toxic Effects of Pesticides
23 Toxic Effects of Metals
24 Toxic Effects of Solvents and Vapors
25 Toxic Effects of Radiation and Radioactive Materials
26 Toxic Effects of Terrestrial Animal Venoms and Poisons
27 Toxic Effects of Plants
Unit 6 Environmental Toxicology
28 Air Pollution
29 Ecotoxicology
Unit 7 Applications of Toxicology
30 Food Toxicology
31 Analytic/Forensic Toxicology
32 Clinical Toxicology
33 Occupational Toxicology
34 Regulatory Toxicology
App Recommended Limits for Occupational Exposure to Chemicals
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)