Casarett & Doull's Essentials of Toxicology / Edition 1

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2003 Trade paperback Annotated. New. Trade paperback (US). Glued binding. 548 p. Contains: Illustrations. Audience: General/trade. *****PLEASE NOTE: This item is shipping from ... an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Based on the Gold Standard in the field!

For over 25 years, Casarett & Doull’s Toxicology has set the standard for providing thorough, academic, and authoritative information and remains the leading reference in the literature.

Derived from this classic, CASARETT & DOULL’S ESSENTIALS OF TOXICOLOGY uses a highly readable, extensively illustrated approach to provide an in-depth understanding of the principles of toxicology and how poisons affect the body.

You’ll learn about basic principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents ─ from pesticides to radiation.


*Provides the benefits of the leading reference without the bulk

*Ideal for course work or as a concise reference

*Presents concepts in logical progression from general principles to specific topics and examples

*Chapter Outlines overview study points and make review fast and easy by noting specific topics and examples

*Simple, clear illustrations communicate complex concepts and reinforce comprehension

*Summary Tables distill important information

*Key Points sections summarize each chapter

*Review Questions assess your comprehension of content

*End-of-chapter Bibliographies facilitate further study or research

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Editorial Reviews

Doody's Review Service
Reviewer: Kara E Warner, BA, MS (Oregon State University)
Description: This book is adapted from Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th edition (McGraw-Hill, 2001), and, as promised, it is highly readable and contains helpful illustrations and tables. The content is clearly organized and flows from mechanisms of toxicity to target organ toxicity, and on to specific toxic agents and applications of the study of toxicology.
Purpose: The goal is to help the reader achieve an understanding of the mechanisms of toxicity in target tissues and the agents involved. The book is to serve as a more concise and readable counterpart to its more text-heavy source. It is definitely more approachable, and does serve as an appropriate introduction to toxicology, thereby meeting the authors' goals.
Audience: The book is written for undergraduate and graduate students (according to the author), and it is appropriate for this level. The editors are highly credible authorities in the field.
Features: This book covers an introduction to mechanisms and target sites of toxic agents, classes of toxic substances, and a review of the applications and careers involved in toxicological studies. It is very readable, and contains an adequate amount of figures (although a bit lacking in some chapters, but great in others) and tables. The chapters dealing with target organ toxicity are especially well organized. The appendix is extremely helpful and essential. The chapters give key points that perhaps should be listed at the end to allow the reader to review that section's content. The review questions at the end of the book are helpful and relevant, but should be placed at the end of each chapter to test the reader's absorption of the pertinent material. Specific case studies (separated from the text) would be an excellent way of providing examples of mechanisms or applications of toxicity, and would help engage the reader.
Assessment: This book serves as a highly useful introduction to toxicology, and I would recommend it to students entering the field before the main textbook.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780071389143
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 6/26/2003
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 548
  • Product dimensions: 7.30 (w) x 9.20 (h) x 0.81 (d)

Meet the Author

Curtis D. Klaassen, PhD, Professor of Pharmacology and Toxicology, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas

John B. Watkins III, PhD, Professor of Pharmacology and Toxicology, Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana

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Table of Contents

Unit 1 General Principles of Toxicology 1
1 History and Scope of Toxicology 3
2 Principles of Toxicology 6
3 Mechanisms of Toxicity 21
4 Risk Assessment 46
Unit 2 Disposition of Toxicants 57
5 Absorption, Distribution, and Excretion of Toxicants 59
6 Biotransformation of Xenobiotics 71
7 Toxicokinetics 98
Unit 3 Nonorgan-Directed Toxicity 109
8 Chemical Carcinogenesis 111
9 Genetic Toxicology 131
10 Developmental Toxicology 146
Unit 4 Target Organ Toxicity 161
11 Toxic Responses of the Blood 163
12 Toxic Responses of the Immune System 176
13 Toxic Responses of the Liver 194
14 Toxic Responses of the Kidney 208
15 Toxic Responses of the Respiratory System 220
16 Toxic Responses of the Nervous System 233
17 Toxic Responses of the Ocular and Visual System 252
18 Toxic Responses of the Heart and Vascular Systems 266
19 Toxic Responses of the Skin 288
20 Toxic Responses of the Reproductive System 301
21 Toxic Responses of the Endocrine System 316
Unit 5 Toxic Agents 331
22 Toxic Effects of Pesticides 333
23 Toxic Effects of Metals 348
24 Toxic Effects of Solvents and Vapors 360
25 Toxic Effects of Radiation and Radioactive Materials 372
26 Toxic Effects of Terrestrial Animal Venoms and Poisons 384
27 Toxic Effects of Plants 396
Unit 6 Environmental Toxicology 405
28 Air Pollution 407
29 Ecotoxicology
Unit 7 Applications of Toxicology 429
30 Food Toxicology 431
31 Analytic/Forensic Toxicology 440
32 Clinical Toxicology 447
33 Occupational Toxicology 453
34 Regulatory Toxicology 462
Self-Assessment Questions and Answers 468
Index 487
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