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Casarett & Doull's Essentials of Toxicology, Second Edition / Edition 2

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Overview

The most concise and authoritative introduction to the principles of toxicology and how poisons affect the human body – now in full color

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the field’s gold-standard text Casarett & Doull’s Toxicology: The Basic Science of Poisons. Presented in full color for the first time, the book combines an accessible and engaging approach with coverage of essential introductory concepts to provide you with a solid grounding in basic and medical toxicology. Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents – from pesticides to radiation.

Features:

  • A complete basic overview of poisons and their clinical management
  • Reflects the expertise of more than fifty renowned contributors
  • A summary of important points is included at the beginning of each chapter and multiple-choice review questions appear at the conclusion
  • Important chapters on forefront topics such as Analytic/Forensic Toxicology, Clinical Toxicology, Occupational Toxicology, Air Pollution, and Ecotoxicology

Condensed Table of Contents: General Principles of Toxicology, Disposition of Toxicants, Nonorgan-Directed Toxicity, Target Organ Toxicity, Toxic Agents, Environmental Toxicology, Applications of Toxicology.

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Product Details

  • ISBN-13: 9780071622400
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 7/12/2010
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 472
  • Sales rank: 252,509
  • Product dimensions: 8.78 (w) x 11.08 (h) x 0.66 (d)

Meet the Author

Curtis D. Klaassen, PhD

University Distinguished Professor and Chair

Department of Pharmacology, Toxicology, and Therapeutics

University of Kansas Medical Center

Kansas City, KS

John B. Watkins, III, PhD

Assistant Dean and Director

Professor of Pharmacology and Toxicology

Medical Sciences Program

Indiana University School of Medicine

Bloomington, IN

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Table of Contents

Contributors

Preface

UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1

1 History and Scope of Toxicology Michael A. Gallo Gallo, Michael A. 1

2 Principles of Toxicology Steven G. Gilbert Gilbert, Steven G. 5

3 Mechanisms of Toxicity Zoltan Gregus Gregus, Zoltan 21

4 Risk Assessment Gilbert S. Omenn Omenn, Gilbert S. 47

UNIT 2 DISPOSITION OF TOXICANTS 57

5 Absorption, Distribution, and Excretion of Toxicants Lois D. Lehman-McKeeman Lehman-McKeeman, Lois D. 57

6 Biotransformation of Xenobiotics Brian W. Ogilvie Ogilvie, Brian W. 71

7 Toxicokinetics Danny D. Shen Shen, Danny D. 99

UNIT 3 NONORGAN-DIRECTED TOXICITY 109

8 Chemical Carcinogenesis Lisa M. Kamendulis Kamendulis, Lisa M. 109

9 Genetic Toxicology George R. Hoffmann Hoffmann, George R. 123

10 Developmental Toxicology Robert J. Kavlock Kavlock, Robert J. 135

UNIT 4 TARGET ORGAN TOXICITY 147

11 Toxic Responses of the Blood John T. Brandt Brandt, John T. 147

12 Toxic Responses of the Immune System Michael P. Holsapple Holsapple, Michael P. 161

13 Toxic Responses of the Liver Hartmut Jaeschke Jaeschke, Hartmut 177

14 Toxic Responses of the Kidney Rick G. Schnellmann Schnellmann, Rick G. 191

15 Toxic Responses of the Respiratory System Jerold A. Last Last, Jerold A. 203

16 Toxic Responses of the Nervous System Martin A. Philbert Philbert, Martin A. 217

17 Toxic Responses of the Ocular and Visual System William K. Boyes Boyes, William K. 233

18 Toxic Responses of the Heart and Vascular System Y. James Kang Kang, Y. James 247

19 Toxic Responses of the Skin Theodora M. Mauro Mauro, Theodora M. 267

20 Toxic Responses of the Reproductive System L. Earl Gray Jr Gray, L. Earl, Jr 279

21 Toxic Responses of the Endocrine System Charles C. Capen Capen, Charles C. 293

UNIT 5 TOXIC AGENTS 309

22 Toxic Effects of Pesticides Lucio G. Costa Costa, Lucio G. 309

23 Toxic Effects of Metals Michael P. Waalkes Waalkes, Michael P. 323

24 Toxic Effects of Solvents and Vapors D. Alan Warren Warren, D. Alan 335

25 Toxic Effects of Radiation and Radioactive Materials Naomi H. Harley Harley, Naomi H. 347

26 Toxic Effects of Terrestrial Animal Venoms and Poisons John B. Watkins III Watkins, John B., III 359

27 Toxic Effects of Plants, Fungi, and Algae Stata Norton Norton, Stata 369

UNIT 6 Environmental Toxicology 377

28 Air Pollution Daniel L. Costa Costa, Daniel L. 377

29 Ecotoxicology Michael C. Newman Newman, Michael C. 389

UNIT 7 APPLICATIONS OF TOXICOLOGY 399

30 Food Toxicology George A. Burdock Burdock, George A. 399

31 Analytic/Forensic Toxicology Alphonse Poklis Poklis, Alphonse 409

32 Clinical Toxicology Louis R. Cantilena Jr Cantilena, Louis R., Jr 415

33 Occupational Toxicology Peter S. Thorne Thorne, Peter S. 425

Answers to Chapter Questions 435

Index 439

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