- Shopping Bag ( 0 items )
From The CriticsReviewer: Jed N. Lampe, Ph.D.(University of Kansas Medical Center)
Description: These are challenging times for the pharmaceutical industry. Expiring patent cliffs together with the dearth of FDA-approved new chemical entities and the cost to bring those entities to market have led to a substantial downsizing of industrial R&D efforts. Continuing questions have been: How can we efficiently bring new drugs to market? What can we learn from past successful efforts? Are there proven design principles and technologies that we can use to increase the probability of success? This comprehensive book addresses these questions with a series of vignettes or case studies of several different classes of drugs.
Purpose: By reviewing specific examples from previous drug design and discovery efforts, the authors hope to illustrate key concepts from successful (and not so successful) drug discovery programs, a review sorely needed for the ailing pharmaceutical industry. The use of specific examples as a pedagogical tool is a time-honored and efficacious approach, which is employed with a high degree of success in this book.
Audience: Although this book is primarily geared toward student and postdoctoral researchers, it could easily prove valuable to more seasoned scientists, particularly those charged with teaching responsibilities. Combined, the authors have many years of experience dealing with the problems of drug discovery and design at the bench, and it shows in their choice of case study examples and how they approach them.
Features: The book presents a comprehensive list of examples of successful drug discovery projects, from novel glucose lowering agents to the classic stories of the discovery of artemisinin and imatinib. One unusual feature included in this book is an appendix on small molecule drug discovery and development, which student readers will no doubt find useful. Although the book features many illustrations, additional color figures would enhance key concepts.
Assessment: This book will enrich the collection of medicinal chemists or pharmacologists involved in active drug discovery research, as well as students with a passion for pursuing a career in drug discovery.