Casting Type Calcifications: Sign of a Subtype with Deceptive Features

Casting Type Calcifications: Sign of a Subtype with Deceptive Features

by Laszlo Tabar, Tibor Tot, Peter B. Dean
     
 

ISBN-10: 1588905802

ISBN-13: 9781588905802

Pub. Date: 04/30/2007

Publisher: Thieme

In Breast Cancer: The Art and Science of Early Detection with Mammography-Perception, Interpretation, Histopathologic Correlation, Lszl Tabr, one of the world's most renowned mammographers, has shared his decades of experience in presenting the fundamentals of perception and interpretation of mammographic images. This is the second volume in a series of books

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Overview

In Breast Cancer: The Art and Science of Early Detection with Mammography-Perception, Interpretation, Histopathologic Correlation, Lszl Tabr, one of the world's most renowned mammographers, has shared his decades of experience in presenting the fundamentals of perception and interpretation of mammographic images. This is the second volume in a series of books written by the team of Tabr, Tot, and Dean describing breast cancer in its earliest phase according to the imaging findings and correlating these findings with sophisticated histopathologic images and patient outcome. This volume covers a particularly troublesome subtype of breast cancer characterized by casting type calcifications.

Highlights:

  • Extensive coverage of the morphology and outcome of this deceptive breast cancer subtype
  • Nearly 1000 illustrations of stunning quality showing the full range of manifestations
  • Photomicrographs of large, thin-section pathology slides and unique 3D pathology images which are carefully correlated with mammographic images to explain why mammograms appear as they do
  • Stereoscopic images that demonstrate normal breast structures and the distortion caused by this unique malignant process
  • Presentation of an original theory of neoductgenesis to explain the surprising disease outcome all too frequently observed
  • Scientific rationale for using individualized treatment methods which include the mammographic prognostic features

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Product Details

ISBN-13:
9781588905802
Publisher:
Thieme
Publication date:
04/30/2007
Series:
Breast Cancer - Early Detection with Mammography
Pages:
325
Product dimensions:
8.50(w) x 11.90(h) x 1.00(d)

Table of Contents


Description of Calcifications Localized within the Ducts     1
General Introduction     3
Description of Calcifications localized within the Ducts     4
Anatomical Background     4
"Secretory Disease" Type, Plasma Cell Mastitis Type Calcifications     5
Casting Type Calcifications     8
Fragmented and Dotted Casting Type Calcifications     8
Fragmented Casting Type Calcifications on the Mammogram     10
Dotted Casting Type Calcifications on the Mammogram     11
Fragmented Casting Type Calcifications     12
Mammographic Display of Widespread Fragmented Casting Type Calcifications in Five Separate Cases     12
Macroscopic and Subgross Histological Correlation When Fragmented Casting Type Calcifications Fill an Entire Lobe     14
Characteristic Mammographic and Histological Presentation of Fragmented Casting Type Calcifications on the Mammogram     16
Mammographic-Histological Correlation When Both Fragmented Casting Type and Dotted Casting Type Calcifications Are Present     22
Casting Type Calcifications-Differential Diagnostic Problems     28
Dotted Casting Type Calcifications     38
Mammographic Display of Widespread Dotted Casting Type Calcifications in Five Separate Cases     38
Mammographic-Histological Correlationof Dotted Casting Type Calcifications on the Mammogram     40
Mammographic-Histological Correlation of Dotted Casting Type Calcifications Caused by Grade 1 DCIS, a Rare Event     64
The Evolution of Casting Type Calcifications     73
Introduction     75
No Apparent Abnormality on the Previous Mammogram     76
Cluster of Calcifications as the Earliest Sign     80
Subtle Casting Type Calcifications as the Earliest Sign     118
The Theory of Neoductgenesis     127
Introduction     129
Comparison of Benign and Malignant Intraductal Calcifications     130
The Theory of Ductoneogenesis     134
Proposal of the Theory of Neoductgenesis     135
Morphological Demonstration of Neoductgenesis     135
Unnaturally High Concentration of Ductlike Structures within a Limited Area     135
Desmoplastic Reaction and Extensive Lymphocytic Infiltration     135
Disorganized Architecture     138
Pathologic Ducts: Contorted and Crowded Closely Together     139
Histological Demonstration of Multiple Newly Formed Ducts     140
Tenascin Overexpression     154
Neoductgenesis with Asymmetric Density and Very Subtle, Associated Calcifications     164
Neoductgenesis without Associated Calcifications     172
The Deviant Nature of the Breast Cancer Subtype with Castings     181
Introduction     183
The Use of Mammographic Tumor Features to Study Breast Cancer     184
Relative Frequency of Breast Cancer Occurrence by Mammographic Tumor Features     185
Long-Term Outcome by Mammographic Tumor Features     186
Proportion of Breast Cancer Death by Mammographic Tumor Features     192
Demonstration of Fatal Cases with Casting Type Calcifications     194
Poor Correlation of Outcome with Mode of Therapy     204
Demonstration of Local Recurrence Following Radiotherapy     206
Axillary Node Status and Mammographic Tumor Features     214
Histological Malignancy Grade and Mammographic Tumor Features     218
Outcome of 1-14 mm Casting Cases Compared with Advanced Cancers     226
Recognition of the Unpredictable, Often Fatal Nature of the Breast Cancer Subtype Presenting with Casting Type Calcifications on the Mammogram     227
Introduction     229
Examples with Fatal Outcome     230
Frequent Recurrence with Casting Type Calcifications     253
Distant Metastases with Casting Type Calcifications     266
Suggestion for Use of the Mammographic Prognostic Features in Clinical Practice      270
Illustrative Cases with 3-Dimensional Stereoscopic Histological Images     273
Case 6.1     274
Case 6.2     277
Case 6.3     283
Case 6.4     287
Case 6.5     291
Case 6.6     295
Case 6.7     300
References     309
General Introduction     309
Chapter 1     309
Chapter 2     309
Chapter 3     309
Chapter 4     309
Chapter 5     310
Subject Index     311

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