Cell Activation and Apoptosis in HIV Infection: Implications for Pathogenesis and Therapy

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Assembles recent research, presented at a July 1994 international symposium in Paris, on basic and clinical aspects of T-cell activation/apoptosis in HIV infection and their implications for immunotherapy. Sections on T-cell/macrophage activation and HIV infection, apoptosis and viropathogenesis of HIV disease, apoptosis and immunopathogenesis of HIV disease, and mediators of T-cell activation/apoptosis describe advances in the field and explain the rationales for immune-cell-targeted therapeutic interventions. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781461358237
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #374
  • Edition description: Softcover reprint of the original 1st ed. 1995
  • Edition number: 1
  • Pages: 245
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.55 (d)

Table of Contents

1 CD4+ and CD8+ T Lymphocyte Activation in HIV Infection: Implications for Immune Pathogenesis and Therapy 1
2 Markers of Immune Cell Activation and Disease Progression: Cell Activation in HIV Disease 17
3 The Role of the Cell Cycle in HIV-1 Infection 27
4 Molecular Basis of Cell Cycle Dependent HIV-1 Replication: Implications for Control of Virus Burden 33
5 Regulation of Macrophage Activation and HIV Replication 47
6 Investigations on Autologous T-Cells for Adoptive Immunotherapy of AIDS 57
7 Rational Problems Associated with the Development of Cellular Approaches in Controlling HIV Spread 71
8 The Role of Surface CD4 in HIV-Induced Apoptosis 91
9 Mechanism of Apoptosis in Peripheral Blood Mononuclear Cells of HIV-Infected Patients 101
10 Programmed Death of T Cells in the Course of HIV Infection 115
11 T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection 121
12 Apoptosis during HIV Infection: A Cytopathic Effect of HIV or an Important Host-Defense Mechanism against Viruses in General? 129
13 From Cell Activation to Cell Depletion: The Programmed Cell Death Hypothesis of AIDS Pathogenesis 139
14 Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology: Implication for AIDS 165
15 Clonal Expansion of T Cells and HIV Genotypes in Microdissected Splenic White Pulps Indicates Viral Replication in Situ and Infiltration of HIV-Specific Cytotoxic T Lymphocytes 173
16 Autoimmunity, Apoptosis Defects, and Retroviruses 183
17 AIDS as Immune System Activation: Key Questions that Remain 203
18 Inhibition of T Lymphocyte Activation and Apoptotic Cell Death by Cyclosporin A and Tacrolimus (FK506): Its Relevance to Therapy of HIV Infection 211
19 Cyclophilin and Gag in HIV-1 Replication and Pathogenesis 217
20 Long-Term Follow-up of HIV Positive Asymptomatic Patients Having Received Cyclosporin A 229
21 Prospective Views of HIV Pathology: Clues for Therapeutic Strategies 235
Index 243
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