Cell and Molecular Biology: Concepts and Experiments / Edition 5

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Balances coverage of the concepts of cell and molecular biology, using examples of experimentation to support those concepts. As experimental techniques become more diverse and complex, it is increasingly necessary to identify individual studies that have a broad impact on our understanding of cell biology. This text describes in detail some of the key experimental findings, along with the original data and figures.
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Editorial Reviews

Intended for use in the single semester or two-quarter sophomore or junior year university course in cellular and molecular biology, this text presents an experimental approach to the field. Additions to this second edition include increased coverage of immunology, additional segments, and updated illustrations, as well as general editing and condensing. Includes a fairly detailed glossary of key terms and concepts. Annotation c. by Book News, Inc., Portland, Or.
From The Critics
New edition of a text that emphasizes fundamental concepts, such as the relationship between molecular structure and function, the dynamic character of cellular organelles, the mechanisms that regulate cellular activities, as well as the use of chemical energy in running cellular activities and ensuring accurate macromolecular biosynthesis, unity and diversity at the macromolecular and cellular levels. The 18 chapters include new topics such as the use of molecular techniques to discover previously unsuspected prokaryote diversity, energy landscape models of protein unfolding, photoinhibition of the photosynthetic machinery of chloroplasts by bright light, recent insights from the sequencing of the human genome, and other information that has emerged since the last edition. The included CD-ROM contains animations of text illustrations and self tests. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Bruce A. Fenderson, PhD (Thomas Jefferson University)
Description: The author expertly organizes, explains, and illustrates the chemical and cellular basis of life on Earth in this comprehensive and exciting introduction to cell and molecular biology. The 18 fascinating chapters cover topics ranging from control of gene expression to mechanisms of immune response. There is even a chapter on laboratory techniques. The focus of the book is on biological chemistry, with an emphasis on core concepts and experimental approaches.
Purpose: The purpose is to provide a textbook for an introductory course in cell and molecular biology. The author hopes that students will visualize a world filled with "giant molecules and minuscule structures" that constitute the chemistry of life. He encourages students to consider the evidence that is presented to support a biological model, think of alternate explanations, and plan experiments that may lead to new hypotheses. One of the author's goals is to help students develop their independent, critical-thinking skills.
Audience: This is an excellent companion textbook for undergraduate and graduate-level courses in cell and molecular biology. It is written for students across a wide range of life science disciplines including general biology, developmental biology, biochemistry, and biophysics. The author is an outstanding research scientist and highly skilled educator who knows how to communicate effectively.
Features: This updated edition is filled with new micrographs and computer-generated images. The large, glossy pages are visually stimulating. Each chapter includes an outline and brief introduction. Many sections include open-ended review questions to stimulate critical thinking. Color-coded boxes highlight topics of biomedical interest and details regarding important experimental pathways. Each chapter concludes with a short synopsis and a set of analytical questions that probe students' understanding. Chapters include nifty molecular models, sharp electron micrographs, and colorful data that highlight experimental results. A glossary of keywords and references for additional reading appear at the end of the book. The inside front cover lists Nobel prizes for research since 1958. The inside back cover lists topics covered in the book that are of medical interest (e.g., statins, prions, and transplant rejection). The cover artwork provides an important teaching opportunity: beautiful molecular models illustrate the complexity of synaptic membrane vesicles. The textbook comes with a full complement of ancillaries, including online access to quizzes, flash cards, animations, and complete answers to the end-of-chapter analytical questions. Pre-loaded assignments, teaching presentations, virtual meetings, student support, and short tutorials are also available. In brief, the author and publisher have pulled out all the stops to create an excellent learning resource.
Assessment: Readers will experience a sense of awe and wonder with this book. It is polished in every detail, from the cover art to the colorful illustrations and micrographs that highlight current research. This book is the right size and has the right balance of content for an introductory course in cell and molecular biology, comprehensive yet concise. The open-ended questions that accompany each chapter are thought provoking and will help students learn. The emphasis on topics of medical significance will be appreciated by students interested in the health professions. I highly recommend this textbook for students and faculty in the life sciences.
From the Publisher
"This is an excellent textbook for undergraduate students and would make for an excellent course. It could also be used as supplemental text for abnormal psychology for the discussion of assessment tools, an area to which most undergraduate students do not get adequate exposure. Strongly recommended!" (Doody's, November 2010)
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Product Details

  • ISBN-13: 9780470042144
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 3/14/2007
  • Edition description: Study Guide
  • Edition number: 5
  • Pages: 352
  • Product dimensions: 8.39 (w) x 11.00 (h) x 0.78 (d)

Meet the Author

Gerald C. Karp received a bachelor’s degree from UCLA and a Ph.D. from the University of Washington. He conducted postdoctoral research at the University of Colorado Medical Center before joining the faculty at the University of Florida. Gerry is the author of numerous research articles on the cell and molecular biology of early development. His interests have included the synthesis of RNA in early embryos, the movement of mesenchyme cells during gas- trulation, and cell determination in slime molds. For 13 years, he taught courses in molecular, cellular, and developmental biology at the University of Florida. During this period, Gerry coauthored a text in developmental biology with N. John Berrill and authored a text in cell and molecular biology. Finding it impossible to carry on life as both full-time professor and author, Gerry gave up his faculty position to concentrate on writing. He hopes to revise this text every three years.
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Table of Contents

1 Introduction to the study of cell biology 1
2 The chemical basis of life 32
3 Bioenergetics, enzymes, and metabolism 86
4 The structure of function of the plasma membrane 121
5 Aerobic respiration and the mitochondrion 182
6 Photosynthesis and the chloroplast 217
7 Interactions between cells and their environment 243
8 Cytoplasmic membrane systems : structure, function, and membrane trafficking 279
9 The cytoskeleton and cell motility 334
10 The nature of the gene and the genome 396
11 Expression of genetic material : from transcription to translation 436
12 The cell nucleus and the control of gene expression 492
13 DNA replication and repair 550
14 Cellular reproduction 578
15 Cell signaling and signal transduction : communication between cells 624
16 Cancer 669
17 The immune response 700
18 Techniques in cell and molecular biology 733
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