Cell and Tissue Reaction Engineering / Edition 1by Martin Fussenegger, Regine Eibl, Dieter Eibl, Ralf Portner
Pub. Date: 08/05/2009
Publisher: Springer Berlin Heidelberg
The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
Table of ContentsPart I: Mammalian cells 1. Mammalian cell culture technology – an emerging field (Dieter Eibl, Regine Eibl, Ralf Pörtner) 2. Characteristics of mammalian cells and requirements for cultivation (Ralf Pörtner) 3. Bioreactors for mammalian cells – General overview (Dieter Eibl, Regine Eibl) 4. Special engineering aspects (Peter Czermak, Ralf Pörtner) 5. Bioreactor design and scale-up (Gerado Catapano, Peter Czermak, Regine Eibl, Dieter Eibl, Ralf Pörtner) Part II: Special applications 6. Insect cell-based recombinant protein production (Martin Fussenegger, Winfried Weber) 7. Bioreactors for bioartificial organs (Gerardo Catapano) 8. Plant cell-based bioprocessing (Dieter Eibl, Regine Eibl)
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