Cell and Tissue Reaction Engineering / Edition 1

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Today mammalian cell products, primarily monoclonals, cytokines, recombinant glycoproteins and increasingly vaccines dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells for regenerative medicine have been introduced on the market. This book elucidates the interactions between biological as well as biochemical and engineering principles in processes derived from cell cultures. The authors explain the basic characteristics of mammalian cells related to cultivation systems and the consequences on design and operation of bioreactor systems, so that the importance of cell culture technology as well as differences compared to microbial fermentation technology are understood. Further, special cell culture applications, such as insect cell-based recombinant protein production, bioartificial organs and plant cell-based bioprocessing, are presented.

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Product Details

  • ISBN-13: 9783540681755
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 11/17/2008
  • Series: Principles and Practice Series
  • Edition description: 2009
  • Edition number: 1
  • Pages: 363
  • Product dimensions: 6.30 (w) x 9.40 (h) x 0.70 (d)

Table of Contents

Pt. I Mammalian Cells

1 Mammalian Cell Culture Technology: An Emerging Field D. Eibl Eibl, D. R. Eibl Eibl, R. R. Portner Portner, R. 3

2 Characteristics of Mammalian Cells and Requirements for Cultivation R. Portner Portner, R. 13

3 Bioreactors for Mammalian Cells: General Overview D. Eibl Eibl, D. R. Eibl Eibl, R. 55

4 Special Engineering Aspects P. Czermak Czermak, P. R. Portner Portner, R. A. Brix Brix, A. 83

5 Bioreactor Design and Scale-Up G. Catapano Catapano, G. P. Czermak Czermak, P. R. Eibl Eibl, R. D. Eibl Eibl, D. R. Portner Portner, R. 173

Pt. II Special Applications

6 Insect Cell-Based Recombinant Protein Production W. Weber Weber, W. M. Fussenegger Fussenegger, M. 263

7 Bioreactors for Bioartificial Organs G. Catapano Catapano, G. 279

8 Plant Cell-Based Bioprocessing R. Eibl Eibl, R. D. Eibl Eibl, D. 315

Index 357

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