Cell Culture in Pharmaceutical Research

Overview

Cell biology has made an appreciable impact on the evaluation of physiological and pathophysiological processes leading to a more detailed understanding of the signaling mechanisms by which cells communicate in vivo and in vitro and modify adaptively. By using cell culture models in addition to animal experiments we are now able to better define the overall and the selective potential of drugs. This book is designed to give information on the advantages and limitations and on new aspects and the meaning of cell ...

See more details below
This Hardcover is Not Available through BN.com
Sending request ...

Overview

Cell biology has made an appreciable impact on the evaluation of physiological and pathophysiological processes leading to a more detailed understanding of the signaling mechanisms by which cells communicate in vivo and in vitro and modify adaptively. By using cell culture models in addition to animal experiments we are now able to better define the overall and the selective potential of drugs. This book is designed to give information on the advantages and limitations and on new aspects and the meaning of cell culture models in pharmaceutical research.

Read More Show Less

Product Details

Table of Contents

1 Cell Culture Models: Reliable Tools in Pharmacotoxicology? 1
2 Differentiation of Human Monocytes In Vitro: A Model of Macrophage Ontogeny 9
3 Embryonic Stem Cell Derived Cardiogenesis and Myogenesis 29
4 Embryonic Stem Cells as a Tool for Analyzing Mammalian Hematopoietic Development and Disease 59
5 Tight Junctions and the Blood-Brain Barrier 69
6 Carcinogenesis Studies of Human Cells: Reliable In Vitro Models 79
7 The Use of Animal Tumor Models to Study the Role of the Tumor Microenvironment and Paracrine and Autocrine Growth Mechanisms in Metastasis to Specific Sites 103
8 Cellular Models for Angiogenesis Research 125
9 Effects of Progesterone and Antiprogestins on Gonadotropin Secretion in the Model of Cultured Rat Pituitary Cells 165
10 Effect of Progesterone on Proteins Vectorially Secreted by Glandular Epithelial Cells of Guinea Pig Endometrium: Modulation by Homologous Stroma 191
11 Steroids as Negative Regulators of Granulosa Cell Proliferation and Differentiation 215
12 Applications of Expression Vectors Containing Bicistronic Transcription Units in Mammalian Cells 239
13 Regulation of Progesterone Receptor Activity in Cell Culture Systems and Cell-Free Transcription 267
Subject Index 299
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)