Cell Cycle and Growth Control: Biomolecular Regulation and Cancer / Edition 2

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Overview

Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. The only book to comprehensively cover both the foundations and cutting-edge advances in understanding cell cycle and growth control, this text also contains an expert perspective on innovative strategies for cancer treatment, making it a vital companion for researcher and clinician alike.
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Editorial Reviews

From The Critics
Reviewer: Bruce A. Fenderson, PhD (Thomas Jefferson University)
Description: This book provides a comprehensive review of eukaryotic cell cycle regulation and growth control, with an emphasis on cancer biology. This is an exciting field of study with implications for understanding oncogenesis, wound healing, immunity, and embryonic development. The book includes 21 chapters on diverse topics ranging from regulatory cascades to signal transduction pathways to key mitotic events. Each author pulls together research findings from different experimental systems to comprehensively review the literature.
Purpose: According to the editors, the goals of this book are to present general concepts, experimental strategies, and key findings that enhance our understanding of cell proliferation in normal and neoplastic cells. The contributions are up-to-date and provide readers with extensive reviews of the published literature.
Audience: Written for scientists who have a keen understanding of cell cycle biochemistry, the book is largely focused on protein biochemistry. It is difficult to read unless you are intimately familiar with the terminology and historical development of this field. The authors of the individual chapters are experts.
Features: Beautiful line drawings, color plates, and expert technical writing characterize this book. Each chapter includes an extensive bibliography. The topics are timely, and reflect cutting-edge approaches to our understanding of cell cycle and growth control. For example, I particularly enjoyed reading about the anticancer effects of angiogenesis inhibitors and the temporal-spatial parameters of cell cycle control.
Assessment: This book hopefully will be a stimulus for researchers interested in cell cycle control. Unfortunately, its readability varies from chapter to chapter. The authors assume a high level of prior knowledge, and the over-use of abbreviations (e.g., pea-3, PTEN, p27) creates a major hurdle for non-experts. The authors present details of experimental findings, but do not always take the time to elaborate (or speculate) on broad general principles. In addition, there is considerable overlap between chapters (e.g., most chapters have a discussion of p53). The book would have been improved by the addition of more line drawings and photomicrographs (i.e., more cell biology). However, the book provides a wealth of information and it will be a valuable reference guide for researchers studying mechanisms of normal and aberrant cell growth.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780471250715
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/28/2004
  • Edition description: REV
  • Edition number: 2
  • Pages: 824
  • Product dimensions: 7.34 (w) x 10.28 (h) x 1.70 (d)

Meet the Author

Dr. Gary S. Stein is Haidak Distinguished Professor and Chairman, Department of Cell Biology, and Professor of Medicine, University of Massachusetts Medical School, and Professor of Medicine. He is also Deputy Director for Research at the University of Massachusetts Cancer Center.  The central theme of Dr. Stein’s research has been to discover mechanisms controlling proliferation and differentiation with emphasis on compromised regulation that is linked with disease.   Dr. Stein has also had major and lasting impact in skeletal biology, where he established the foundation for addressing bone tissue specific gene expression, and provided valuable insight into aberrations that accompany the onset and progression of skeletal disease.

Dr. Arthur B. Pardee is Professor Emeritus, Harvard University. For over 20 years he was Professor of Biological Chemistry and Molecular Pharmacology, Harvard University, and Chief, Division of Cell Growth and Regulation, Dana-Farber Cancer Institute. He is an elected fellow of the American Association for the Advancement of Science, and has served as president of the American Society of Biological Chemists and American Association for Cancer Research.  Dr. Pardee's pioneering work in mammalian cells is the foundation for our current understanding of mechanisms that govern competency for proliferation and cell cycle progression.

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Table of Contents

Preface
Contributors
1 Cell fates 3
2 Architectural organization of the regulatory machinery for transcription, replication, and repair : dynamic temporal-spatial parameters of cell cycle control 15
3 Cell cycle regulatory cascades 95
4 Membrane receptors and signal transduction pathways in G[subscript 1 ]: regulation of liver regeneration and T cell proliferation 129
5 Onset of DNA synthesis and S phase 149
6 The progression and regulation of mitotic events 201
7 Cell cycle inhibitory proteins 237
8 Chromatin remodeling and cancer 265
9 Extracellular matrix : tissue-specific regulator of cell proliferation 297
10 Angiogenesis and blood supply 333
11 Regulation of cell growth, differentiation, and death during metamorphosis 369
12 Translational control and the cell cycle 397
13 Telomere structure and function provides insights into the generation of genomic instability and carcinogenesis 451
14 Immortalization by SV40 large T antigen 467
15 Apoptosis signaling in normal and cancer cells 497
16 Mutagenesis, mutations, and DNA repair 525
17 Oncogenes 571
18 Role of the retinoblastoma family in cell cycle progression and growth control 607
19 p53 tumor-suppressor genes 635
20 Cell cycle and growth control : current clinical applications 669
21 Misregulated fate - cancer 707
Index 773
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