Cell Death: The Role of PARP

by Csaba Szabo (Editor)

Overview

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e

Product Details

ISBN-13:	9781040201985
Publisher:	CRC Press
Publication date:	06/22/2000
Series:	Handbooks in Pharmacology and Toxicology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	352
File size:	9 MB

About the Author

Csaba Szabo

Table of Contents

Preface. Cell Death by Energy Depletion: Discovery and Early Developments. Oxidative Stress and PARS Activation. Nitrosative Stress and PARS Acitvation. PARS in Regulating Cell Necrosis and Apoptosis. PARS in Mediating Neuronal Injury in Stroke and Neurotrauma. PARS in Mediating Chronic Neurodegeneration. PARS Activation and Myocardial Reperfusion Injury. Role of PARS Activation in the Pathophysiology of Endotoxic and Hemorrhagic Shock. Role of PARS Activation in Diabetes. PARS Activation and Arthritas. PARS Activation and Inflammatory Bowel Disease. PARS in Regulating Macrophage Activation and Gene Expression. Pharmacological Inhibitors of PARS.

Editorial Reviews

Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme involved in DNA repair, cell differentiation, gene expression, and possibly cell death. Contributors from fields of neuroinjury, myocardial injury, diabetes, shock, and inflammation examine the status of knowledge on PARP and cell death. Coverage includes PARP and apoptosis, PARP isoforms, developments in pharmacological inhibition of PARP, and novel ways of measuring PARP activation. Specific topics include the role of PARP in activation in inflammation, PARP and the pathogenesis of circulatory shock, PARP in the immune system, and PARP as an active participant in programmed cell death and maintenance of genomic stability. The editor is a vice president for research at a private sector company. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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