Cells, Aging, and Human Disease

Cells, Aging, and Human Disease

by Michael B. Fossel
     
 

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ISBN-10: 0195140354

ISBN-13: 9780195140354

Pub. Date: 06/25/2004

Publisher: Oxford University Press, USA

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and

Overview

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.

Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence—and the general model—cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.

The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes—the progerias—the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters—skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes—examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

Product Details

ISBN-13:
9780195140354
Publisher:
Oxford University Press, USA
Publication date:
06/25/2004
Pages:
504
Product dimensions:
9.30(w) x 6.40(h) x 1.20(d)

Table of Contents

Part IThe Aging Cell
1The Context3
2Cell Senescence16
Telomeres, Telomerase, and Cell Senescence16
The History of Cell Senescence24
Telomerase and Its Function28
Is Telomerase Good for Anything?33
3Cell Senescence in Aging38
What Is Cell Senescence?38
The Limited Model: Cells Senesce45
The General Model: Cell Senescence Results in Organismal Aging56
Fertilization Resets Telomere Effects59
Criticism Gone Awry61
Cells to Organisms63
4The Aging Cascade66
The Jigsaw Puzzle of Aging66
Upstream from Cell Division71
Cell Turnover and Gene Expression71
Between Cells: Cells, Tissues, and Pathology73
5Cancer75
Cancer in Its Cellular Context75
Cancer and Cell Senescence76
Diagnosis79
Dermal Cancer82
Hematopoetic Cancer83
Pulmonary Cancer85
Breast Cancer87
Male Genital Cancer90
Female Genital Cancer92
Renal and Urinary Tract Cancer97
Gastrointestinal Cancer99
Central Nervous System Cancer104
Other Cancer107
Prognosis108
Therapy110
6Parasitic Disease122
Pathology and Incidence122
Cell Senescence and Intervention124
Part IIThe Aging Organism
7The Progerias129
What They Are129
Werner Syndrome130
Hutchinson-Gilford Syndrome133
8The Skin140
Structure and Overview140
Aging and Other Pathology143
The Role of Cell Senescence147
Intervention157
9Cardiovascular System161
Structure and Overview161
Aging and Other Pathology162
The Role of Cell Senescence168
Intervention173
10Orthopedic Systems179
Structure and Overview179
Aging and Other Pathology181
The Role of Cell Senescence184
Intervention187
11Hematopoetic and Immune Systems191
Structure and Overview191
Aging and Other Pathology192
The Role of Cell Senescence195
Regulation of Telomerase Expression200
Cell Senescence in other Hematologic Disease States202
Intervention205
12Endocrine Systems208
Structure and Overview208
Aging and Other Pathology211
The Role of Cell Senescence217
Intervention220
13Nervous System224
Structure and Overview224
Aging and Other Pathology227
The Role of Cell Senescence234
Intervention238
14Kidneys245
Structure and Overview245
Aging and Other Pathology248
The Role of Cell Senescence249
Intervention250
15Muscle252
Structure and Overview252
Aging and Other Pathology253
The Role of Cell Senescence256
Intervention258
16Gastrointestinal System261
Structure and Overview261
Aging and Other Pathology263
The Role of Cell Senescence267
Intervention270
17The Eye271
Structure and Overview271
Aging and Other Pathology273
The Role of Cell Senescence277
Intervention280
18Towards Therapy283
Interventions283
Techniques284
Caveats288
Obstacles288
Implications289
References291
Index469

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