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Doody's Review ServiceReviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This book is a single-authored look at cell senescence and how it applies to development of human pathology at an organ level.
Purpose: Its purpose is to summarize the nature of cellular senescence and demonstrate the applicability of this to human pathology at an organ level. This is a worthy objective and the author presents a complete and thorough summary of the field.
Audience: The audience for this title consists mainly of cell biologists and scientists who study aging. This is not a book aimed primarily at clinicians. The author has written other books on the nature of aging.
Features: The book opens with a discussion of the locus of aging and why the author favors cellular aging, particularly how the telomere affects cell division, as a mechanism of cell aging. This introduction is followed by the bulk of the chapters of the book, which review, organ by organ, the effects of cellular aging on organ aging.
Assessment: The references in this book are over one hundred pages long. This book falls into the category of a bibliographical review. The writing is elegant and well conceived. Specialists in cellular aging, biologists considering aging in general and experimental pathologists will find this book a sturdy reference.