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Cells, Aging, and Human Disease

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Overview

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.

Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence—and the general model—cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.

The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes—the progerias—the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters—skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes—examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

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Editorial Reviews

Doody's Review Service
Reviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This book is a single-authored look at cell senescence and how it applies to development of human pathology at an organ level.
Purpose: Its purpose is to summarize the nature of cellular senescence and demonstrate the applicability of this to human pathology at an organ level. This is a worthy objective and the author presents a complete and thorough summary of the field.
Audience: The audience for this title consists mainly of cell biologists and scientists who study aging. This is not a book aimed primarily at clinicians. The author has written other books on the nature of aging.
Features: The book opens with a discussion of the locus of aging and why the author favors cellular aging, particularly how the telomere affects cell division, as a mechanism of cell aging. This introduction is followed by the bulk of the chapters of the book, which review, organ by organ, the effects of cellular aging on organ aging.
Assessment: The references in this book are over one hundred pages long. This book falls into the category of a bibliographical review. The writing is elegant and well conceived. Specialists in cellular aging, biologists considering aging in general and experimental pathologists will find this book a sturdy reference.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780195140354
  • Publisher: Oxford University Press, USA
  • Publication date: 6/25/2004
  • Pages: 504
  • Product dimensions: 9.30 (w) x 6.40 (h) x 1.20 (d)

Meet the Author

Michigan State University
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Table of Contents

1 The context 3
2 Cell senescence 16
3 Cell senescence in aging 38
4 The aging cascade 66
5 Cancer 75
6 Parasitic disease 122
7 The progerias 129
8 The skin 140
9 Cardiovascular system 161
10 Orthopedic systems 179
11 Hematopoetic and immune systems 191
12 Endocrine system 208
13 Nervous system 224
14 Kidneys 245
15 Muscle 252
16 Gastrointestinal system 261
17 The eye 271
18 Towards therapy 283
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