Cellular and Molecular Biology of Airway Chemoreceptors / Edition 1

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Pulmonary Neuroepithelial Bodies (NEBs) are clusters of innervated amine- and peptide-producing cells distributed throughout the airway mucosa and thought to function as hypoxia sensitive airway chemoreceptors involved in respiratory control or other pulmonary homeostatic mechanisms. This book reviews the recent advances in cellular and molecular biology of NEB cells with emphasis on the mechanism of oxygen sensing as well as morphology, ontogeny, molecular markers and in vitro models. The possible functions during neonatal adaptation are discussed, including implications in apnea of prematurity and Sudden Infant Death Syndrome. The book provides a review of alterations in NEBs observed under a variety of experimental and disease conditions, including a discussion of lung cancer in relation to NEB cells.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Five studies of neuroepithelial bodies, described as enigmatic cells searching for a physiological function, for advanced researchers and clinicians. They cover their structure, molecular markers, ontogeny, and distribution; their possible role as airway chemoreceptors; in vitro models for isolating, culturing, and characterizing them and pulmonary neuroendocrine cells; ionic currents and oxygen-sensing mechanisms; and reports from studies made under experimental and disease conditions. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780412108013
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/1/1997
  • Series: Medical Intelligence Unit Ser.
  • Edition number: 1
  • Pages: 140

Table of Contents

1 Structure, Molecular Markers, Ontogeny and Distribution of Pulmonary Neuroepithelial Bodies 1
2 Possible Role of Neuroepithelial Bodies as Airway Chemoreceptors 35
3 In Vitro Models for Isolation, Culture and Characterization of Pulmonary Neuroendocrine Cells and Neuroepithelial Bodies 47
4 Ionic Currents and Oxygen-Sensing Mechanism in Neuroepithelial Body Cells 71
5 Studies on Neuroepithelial Bodies Under Experimental and Disease Conditions 109
6 Concluding Remarks and Future Prospects 131
Index 137
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