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Pulmonary Neuroepithelial Bodies (NEBs) are clusters of innervated amine- and peptide-producing cells distributed throughout the airway mucosa and thought to function as hypoxia sensitive airway chemoreceptors involved in respiratory control or other pulmonary homeostatic mechanisms. This book reviews the recent advances in cellular and molecular biology of NEB cells with emphasis on the mechanism of oxygen sensing as well as morphology, ontogeny, molecular markers and in vitro models. The possible functions during neonatal adaptation are discussed, including implications in apnea of prematurity and Sudden Infant Death Syndrome. The book provides a review of alterations in NEBs observed under a variety of experimental and disease conditions, including a discussion of lung cancer in relation to NEB cells.
The book contains predominantly black-and-white illustrations, with some color illustrations.
|1||Structure, Molecular Markers, Ontogeny and Distribution of Pulmonary Neuroepithelial Bodies||1|
|2||Possible Role of Neuroepithelial Bodies as Airway Chemoreceptors||35|
|3||In Vitro Models for Isolation, Culture and Characterization of Pulmonary Neuroendocrine Cells and Neuroepithelial Bodies||47|
|4||Ionic Currents and Oxygen-Sensing Mechanism in Neuroepithelial Body Cells||71|
|5||Studies on Neuroepithelial Bodies Under Experimental and Disease Conditions||109|
|6||Concluding Remarks and Future Prospects||131|