Written by well-known experts in their respective fields, this book synthesizes recent work on the biology of bone cells at the molecular level. Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death resorption. The authors' special comprehensive treatment of the cellular and molecular mechanisms of bone metabolism makes this book a unique and valuable tool. Cellular and Molecular Biology of Bone provides interested readers-with concise state-of-the-art reviews in bone biology that will enlarge their scope and increase their appreciation of the field. Research in this area has intensified recently due to the increasing incidence of osteoporosis. The editor hopes an understanding of the basic biology of this disease will prove relevant to its prevention and treatment.
Audience: Researchers in developmental biology, physiology, endocrinology, cell and molecular biology, and medical researchers in cancer and aging.
A comprehensive review of the state of the art in the biology of the bone cells at the molecular level, covering the differentiation of these cells, the regulation of their growth and metabolism, and their death and resorption. Among the topics in 16 chapters are osteoblastic cell lineage, bone morphogenetic proteins and their gene expression, recent advances in the biology of retinoids, and molecular biology of cartilage matrix. For undergraduates and newcomers as well as experts in the field. Annotation c. Book News, Inc., Portland, OR (booknews.com)
J.E. Aubin, K. Turksen, and J.N.M. Heersche, Osteoblastic Cell Lineage. G.S. Stein and J.B. Lian, Molecular Mechanisms Mediating Developmental and Hormone Regulated Expression of Genes in Osteoblasts: An Integrated Relationshipof Cell Growth and Differentiation. S.-J. Kim and R.T. Ballock, Cellular and Molecular Biology of Transforming Growth Factor-b. J.M. Wozney, Bone Morphogenetic Proteins and Their Gene Expression. J. Bonadio and S.A. Goldstein, Our Understanding of Inherited Skeletal Fragility and What This Has Taught Us About Bone Structure and Function. M.F. Young, K. Ibaraki, J.M. Kerr, and A.-M. Heegaard, Molecular and Cellular Biology of the Major Non-Collagenous Proteins in Bone. J.W. Pike, T. Stone, K. Ozono, R.A.Kesterson, and S.A. Kerner, Osteocalcin as a Molecular Model for Tissue-Specific Expression and 1,25-Dihydroxyvitamin D3 Regulation. C.K. Glass and M. Brown, Molecular Mechanisms of Estrogen and Thyroid Hormone Action. G. Eichele, C. Thaller, and S.M. Smith, Recent Advances in the Biology of Retinoids. M. Demay, H. Juppner, A.-B. Abou-Samra, G. Segre, and H. Kronenberg, Parathyroid Hormone Biosynthesis and Action: Molecular Analysis of the PTH Gene and PTH/PTHrP Receptor. S. Peleg, G.J. Cote, and R.F. Gagel, Molecular Mechanisms of Calcitonin Gene Transcription and Posttranscriptional RNA Processing. T. Yoneda, Cytokines in Bone: Local Translators in Cell-to-Cell Communications. K. Hruska, Signal Transduction in Osteoblasts and Osteoclasts. R. Baron, J.-H. Ravesloot, L. Neff, M. Chakraborty, D. Chatterjee, A. Lomri, and W. Horne, Cell and Molecular Biology of The Osteoclast. A.E. Grigoriadis, Z.-Q. Wang, and E.F. Wagner, c-Fos Oncogene Expression in Cartilage and Bone Tissues of Transgenic and Chimaeric Mice. S. Line, C. Rhodes, and Y. Yamada, Cellular and Molecular Biology of the Bone.