Cellular and Molecular Immunology / Edition 5

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The meticulously revised and updated New Edition of this highly acclaimed text continues to provide a concise and straightforward approach to the subject. It focuses on the experimental observations that underlie the science of immunology at the molecular, cellular, and whole organism level—and explores the conclusions that can be drawn from those observations.
  • Highlights the implications of immunologic science for the management of human disease.
  • Features over 365 full-color illustrations that highlight important processes and concepts, and bring the three-dimensional structures of molecules to life.
  • Offers a wealth of reader-friendly features including major concepts highlighted in bold italics · at-a-glance boxes that present specialized information and explanations of current technological approaches · a wealth of tables that summarize key information · a glossary of terms · a CD Molecule Appendix that reflects the latest properties of known CD Molecules · an appendix on immunologic laboratory techniques · and more.
  • Incorporates the newest understandings of basic science as well as the newest research findings.
  • Includes new information on the organization of lymphoid organs and mechanisms of innate immunity.
  • Presents enhanced, more straightforawrd explanations of subjects such as of antigen-presenting cells and the biology of T cell activation.

The book contains predominantly color illustrations, with some black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the fifth edition of a popular textbook on basic immunology. It has been updated so that it incorporates new scientific information that has been published and accepted by the immunological community since the previous edition, published in 2000.
Purpose: The purpose is to give students an explanation of the experimental observations that form the basis for immunology at the molecular, cellular, and whole organism levels. It further explains how the immune system is involved in human disease thus providing the student with a clinical context for the material. For the medical or dental student faced with finding contextual significance for the large amount of basic science material that s/he is required to absorb, the book provides a guide through the sometimes difficult language and concepts of immunology. While there are a large number of immunology textbooks on the market, this book is one in which a student will find explanations for most questions about immunological concepts that s/he might have.
Audience: The book is targeted to medical, dental, and graduate students taking an immunology course that includes both the essential components of the immune system and how they function in immune responses, as well as the immune system in disease. It is useful as a source of information for anyone at any level of competence. The authors are well known and highly respected immunologists.
Features: The book covers all those topics that are usually discussed in any standard immunology course. Although the chapter headings are the same as those in the fourth edition, there are substantial changes. Information in some areas has expanded enormously and is reflected in new material on topics relating to innate immunity and signal transduction. Some new figures have been added and others have been modified so that they are easier to understand. Some of the colors are more intense than in the fourth edition. Tables have been redesigned so that they are much easier to read. As in the past, "boxes" have been used to present information about experimental approaches, diseases, and some specific molecular or biological processes. Taken together, all of these changes have improved what was already a user-friendly and very readable textbook. As before, there are three appendixes: a glossary; principal features of CD molecules; and laboratory techniques. Most basic courses will include some information from each chapter in the book, although the level of detail required will certainly vary. There are still some idiosyncratic features. For example, Type II hypersensitivity reactions now precede Type III and Type IV hypersensitivity reactions with autoimmunity (often a separate chapter) at the end. However, as in the previous edition, this is followed by Type I hypersensitivity as a separate chapter. There is probably a rationale for this untraditional order but it isn't obvious. Other textbooks have included case studies that provide relevance, particularly with respect to basic concepts. Unfortunately this book does not have this kind of reinforcement. On the other hand, the summary at the end of each chapter focuses the attention of the student towards the importance of the material just presented.
Assessment: Immunology is a constantly changing field so there is a need for frequent revisions so that textbooks remain current and accurate. Thus there is a good rationale for publishing this new edition. The fourth edition was an attractive book and the fifth is even more attractive with clearer figures and tables. The book is easy to read and while it is targeted to students, it could serve as a reference for anyone who needs some background information on basic immunology as well as immune-mediated diseases. There are a number of immunology textbooks currently on the market. Although some of the others may have some features that are useful, as an all-purpose book for teaching medical, dental, and graduate students, this book is certainly one of the best.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780721600086
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/5/2003
  • Edition description: Older Edition
  • Edition number: 5
  • Pages: 576
  • Product dimensions: 8.49 (w) x 10.98 (h) x 1.09 (d)

Meet the Author

Abul K. Abbas, MBBS, Chairman Department of Pathology, UCSF School of Medicine,San Francisco, CA

Andrew H. Lichtman, MD, PhD, Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Jordan S. Pober, MD, PhD, Professor of Pathology, Immunobiology, and Dermatology, Yale University School of Medicine, New Haven, CT

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Table of Contents

I. Introduction to Immunology. General Properties of Immune Responses. Cells and Tissues of the Immune System. II. Recognition of Antigens. Antibodies and Antigens. The Major Histocompatibility Complex. Antigen Processing and Presentation to Lymphocytes. Antigen Receptors and Accessory Molecules of T Lymphocytes. III. Maturation, Activation, and Regulation of Lymphocytes. Lymphocyte Maturation and Expression of Antigen Receptor Genes. Activation of T Lymphocytes. Activation of B Lymphocytes and Antibody Production. Immunological Tolerance. IV. Effector Mechanisms of Immune Responses. Cytokines. Innate Immunity. Cell-Mediated Immunity. Humoral Immunity. V. Immunity in Defence and Disease. Immunity to Microbes. Transplantation. Immunity to Tumors. Hypersensitivity Diseases and Autoimmunity. Immediate Hypersensitivity. Congenital and Acquired Immunodeficiencies.
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Customer Reviews

Average Rating 5
( 2 )
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Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted April 18, 2003

    Great review of immunology

    This book offers a concise review of immunology that is easy to read. The artwork is an essential part of the book, as it assists in explaining a complex subject. The authors do a nice job of mixing in clinically relevant facts and historical information that helps the reader understand key concepts.

    Was this review helpful? Yes  No   Report this review
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