Cellular and Molecular Immunology / Edition 4

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Overview

This well known text describes the principles of basic and applied immunology, relying on classical experimental studies and clinical scenarios to highlight major concepts. The emphasis is on concepts and the book aims to synthesis the wealth of information cohesively. Medically relevant information is summarized and specialized information and modern technical approaches are summarised in `Boxes' for the reader who wishes to look at the topic in further depth.

The book contains predominantly color illustrations, with some black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the fifth edition of a popular textbook on basic immunology. It has been updated so that it incorporates new scientific information that has been published and accepted by the immunological community since the previous edition, published in 2000.
Purpose: The purpose is to give students an explanation of the experimental observations that form the basis for immunology at the molecular, cellular, and whole organism levels. It further explains how the immune system is involved in human disease thus providing the student with a clinical context for the material. For the medical or dental student faced with finding contextual significance for the large amount of basic science material that s/he is required to absorb, the book provides a guide through the sometimes difficult language and concepts of immunology. While there are a large number of immunology textbooks on the market, this book is one in which a student will find explanations for most questions about immunological concepts that s/he might have.
Audience: The book is targeted to medical, dental, and graduate students taking an immunology course that includes both the essential components of the immune system and how they function in immune responses, as well as the immune system in disease. It is useful as a source of information for anyone at any level of competence. The authors are well known and highly respected immunologists.
Features: The book covers all those topics that are usually discussed in any standard immunology course. Although the chapter headings are the same as those in the fourth edition, there are substantial changes. Information in some areas has expanded enormously and is reflected in new material on topics relating to innate immunity and signal transduction. Some new figures have been added and others have been modified so that they are easier to understand. Some of the colors are more intense than in the fourth edition. Tables have been redesigned so that they are much easier to read. As in the past, "boxes" have been used to present information about experimental approaches, diseases, and some specific molecular or biological processes. Taken together, all of these changes have improved what was already a user-friendly and very readable textbook. As before, there are three appendixes: a glossary; principal features of CD molecules; and laboratory techniques. Most basic courses will include some information from each chapter in the book, although the level of detail required will certainly vary. There are still some idiosyncratic features. For example, Type II hypersensitivity reactions now precede Type III and Type IV hypersensitivity reactions with autoimmunity (often a separate chapter) at the end. However, as in the previous edition, this is followed by Type I hypersensitivity as a separate chapter. There is probably a rationale for this untraditional order but it isn't obvious. Other textbooks have included case studies that provide relevance, particularly with respect to basic concepts. Unfortunately this book does not have this kind of reinforcement. On the other hand, the summary at the end of each chapter focuses the attention of the student towards the importance of the material just presented.
Assessment: Immunology is a constantly changing field so there is a need for frequent revisions so that textbooks remain current and accurate. Thus there is a good rationale for publishing this new edition. The fourth edition was an attractive book and the fifth is even more attractive with clearer figures and tables. The book is easy to read and while it is targeted to students, it could serve as a reference for anyone who needs some background information on basic immunology as well as immune-mediated diseases. There are a number of immunology textbooks currently on the market. Although some of the others may have some features that are useful, as an all-purpose book for teaching medical, dental, and graduate students, this book is certainly one of the best.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780721682334
  • Publisher: Elsevier Health Sciences
  • Publication date: 5/19/2000
  • Edition description: Older Edition
  • Edition number: 4
  • Pages: 553
  • Product dimensions: 8.54 (w) x 10.92 (h) x 0.90 (d)

Meet the Author

Abul K. Abbas, MBBS, Chairman Department of Pathology, UCSF School of Medicine,San Francisco, CA

Andrew H. Lichtman, MD, PhD, Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Jordan S. Pober, MD, PhD, Professor of Pathology, Immunobiology, and Dermatology, Yale University School of Medicine, New Haven, CT

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Table of Contents

SECTION I INTRODUCTION TO IMMUNOLOGY 1
CHAPTER 1 GENERAL PROPERTIES OF IMMUNE RESPONSES 3
CHAPTER 2 CELLS AND TISSUES OF THE IMMUNE SYSTEM 14
SECTION II LYMPHOCYTE SPECIFICITY AND ACTIVATION 31
CHAPTER 3 ANTIBODIES AND ANTIGENS 33
CHAPTER 4 MATURATION OF B LYMPHOCYTES AND EXPRESSION OF IMMUNOGLOBULIN GENES 65
CHAPTER 5 THE MAJOR HISTOCOMPATIBILITY COMPLEX 96
CHAPTER 6 ANTIGEN PROCESSING AND PRESENTATION TO T LYMPHOCYTES 115
CHAPTER 7 MOLECULAR BASIS OF T CELL ANTIGEN RECOGNITION AND ACTIVATION 136
CHAPTER 8 T CELL MATURATION IN THE THYMUS 166
CHAPTER 9 B CELL ACTIVATION AND ANTIBODY PRODUCTION 187
CHAPTER 10 REGULATION OF IMMUNE RESPONSES 205
CHAPTER 11 FUNCTIONAL ANATOMY OF LOCAL AND SYSTEMIC IMMUNE RESPONSES 222
SECTION III EFFECTOR MECHANISMS OF IMMUNE RESPONSES 237
CHAPTER 12 CYTOKINES 239
CHAPTER 13 EFFECTOR MECHANISMS OF T CELL-MEDIATED IMMUNE REACTIONS 261
CHAPTER 14 EFFECTOR MECHANISMS OF IMMUNOGLOBULIN E-INITIATED IMMUNE REACTIONS 278
CHAPTER 15 THE COMPLEMENT SYSTEM 293
SECTION IV IMMUNITY IN DEFENSE AND DISEASE 317
CHAPTER 16 IMMUNITY TO MICROBES 319
CHAPTER 17 IMMUNE RESPONSES TO TISSUE TRANSPLANTS 337
CHAPTER 18 IMMUNITY TO TUMORS 356
CHAPTER 19 SELF-TOLERANCE AND AUTOIMMUNITY 376
CHAPTER 20 IMMUNE-MEDIATED TISSUE INJURY AND DISEASE 393
CHAPTER 21 CONGENITAL AND ACQUIRED IMMUNODEFICIENCIES 409
APPENDIX PRINCIPAL FEATURES OF KNOWN CD MOLECULES 431
INDEX 437
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Sort by: Showing all of 2 Customer Reviews
  • Anonymous

    Posted October 11, 2001

    Fantastic Textbook!

    This book did a wonderful job of organizing and explaining the material. The figures were extremely clear, and coming from a person with little prior knowledge of Immunology, this book really made the subject matter interesting and understandable.

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  • Anonymous

    Posted August 28, 2000

    Excellent figures

    Immunology is a complex subject. This text has excellent multi-color figures to help out. I have yet to find an other book that can match this one.

    Was this review helpful? Yes  No   Report this review
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