Cellular Engineering and Cellular Therapies: Proceedings of the Twenty-Seventh International Symposium on Blood Transfusion, Groningen, Organized by the Sanquin Division Blood Bank North-East, Groningen / Edition 1

Cellular Engineering and Cellular Therapies: Proceedings of the Twenty-Seventh International Symposium on Blood Transfusion, Groningen, Organized by the Sanquin Division Blood Bank North-East, Groningen / Edition 1

by Cees Smit Sibinga
     
 

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ISBN-10: 1402017138

ISBN-13: 9781402017131

Pub. Date: 10/31/2003

Publisher: Springer US

Transfusion Medicine is a rapidly developing field of science which increasingly needs the bridging between fundamental biomedical research and applied research - this bridging is also recognised as translational research. The field of engineering of potential cells for therapeutic application does not only cover gene therapy, but also covers the manipulation of

Overview

Transfusion Medicine is a rapidly developing field of science which increasingly needs the bridging between fundamental biomedical research and applied research - this bridging is also recognised as translational research. The field of engineering of potential cells for therapeutic application does not only cover gene therapy, but also covers the manipulation of cellular characteristics and functional capacities. Harvest, preservation and manipulation of specific cells circulating in the peripheral blood extend beyond the conventional technologies. Where the procurement of human blood cells has been the field of expertise of the conventional blood bank, this extension should be regarded as a development of the field into a new direction. This new direction needs a change in philosophy, approach and expertise where an integrated collaborative attitude with the academic world is of paramount importance. This book provides the complete gamma of aspects, both academic and blood banking, of this fascinating new field of science and clinical application. It illustrates the potential possibilities and future opportunities to add new therapeutic directions to clinical medicine.

Product Details

ISBN-13:
9781402017131
Publisher:
Springer US
Publication date:
10/31/2003
Series:
Developments in Hematology and Immunology (closed) Series, #38
Edition description:
2004
Pages:
223
Product dimensions:
9.21(w) x 6.14(h) x 0.56(d)

Table of Contents

Moderators and SpeakersIX
ForewordXIII
I.Defining the Field
Cellular Engineering and Cellular Therapies--an Overview3
Gene Therapy 2002: A New Start11
Stem Cells: Potential, Selection and Plasticity21
The Potential of Stem Cell Transplantation to Rescue the Failing Liver31
Discussion35
II.Processing Aspects
The New Regulatory Environment for Cellular Therapy Products: Challenges for Academic-Based Manufacturing Facilities45
Biological Modification of Lymphocytes on Auto- and Allo-Immune Diseases55
Cell Harvest and Purification Technology--State of the Art and Future Development69
Cell Manipulation and Engineering--State of the Art and Future Developments81
Cellular Immunotherapy--Towards Direct DC Activation for Licence to Kill89
Discussion95
III.Quality Aspects
From Research to Clinical Application - the Quality Concept111
Factors Controlling Expansion and Maturation of Haematopoietic Progenitor Cells119
Cell Processing for Gene and Cell Therapy Protocols: Limitations and Opportunities!133
Discussion139
IV.Clinical Experiences and Prospect for Treatment
State of the Art in Dendritic Cell Vaccination153
Reconstituting T Cell Immunity Following Hematopoietic Stem Cell Transplantation161
State of the Art in Gene Therapy171
New Horizons in Cellular Therapies189
Cellular Engineering and Cellular Therapies--Transfusion Medicine and the Academic World203
Discussion207
Index215

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