Cellular Engineering and Cellular Therapies: Proceedings of the Twenty-Seventh International Symposium on Blood Transfusion, Groningen, Organized by the Sanquin Division Blood Bank North-East, Groningen / Edition 1

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Transfusion Medicine is a rapidly developing field of science which increasingly needs the bridging between fundamental biomedical research and applied research - this bridging is also recognised as translational research. The field of engineering of potential cells for therapeutic application does not only cover gene therapy, but also covers the manipulation of cellular characteristics and functional capacities. Harvest, preservation and manipulation of specific cells circulating in the peripheral blood extend beyond the conventional technologies. Where the procurement of human blood cells has been the field of expertise of the conventional blood bank, this extension should be regarded as a development of the field into a new direction. This new direction needs a change in philosophy, approach and expertise where an integrated collaborative attitude with the academic world is of paramount importance. This book provides the complete gamma of aspects, both academic and blood banking, of this fascinating new field of science and clinical application. It illustrates the potential possibilities and future opportunities to add new therapeutic directions to clinical medicine.

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Table of Contents

Moderators and Speakers
Cellular Engineering and Cellular Therapies - an Overview 3
Gene Therapy 2002: A New Start 11
Stem Cells: Potential, Selection and Plasticity 21
The Potential of Stem Cell Transplantation to Rescue the Failing Liver 31
The New Regulatory Evnrionment for Cellular Therapy Products: Challenges for Academic-Based Manufacturing Facilities 45
Biological Modification of Lymphocytes on Auto- and Allo-Immune Diseases 55
Cell Harvest and Purification Technology - State of the Art and Future Development 69
Cell Manipulation and Engineering - State of the Art and Future Developments 81
Cellular Immunotherapy - Towards Direct DC Activation for Licence to Kill 89
From Research to Clinical Application - the Quality Concept 111
Factors Controlling Expansion and Maturation of Haematopoietic Progenitor Cells 119
Cell Processing for Gene and Cell Therapy Protocols: Limitations and Opportunities! 133
State of the Art in Dendritic Cell Vaccination 153
Reconstituting T Cell Immunity Following Hematopoietic Stem Cell Transplantation 161
State of the Art in Gene Therapy 171
New Horizons in Cellular Therapies 189
Cellular Engineering and Cellular Therapies - Transfusion Medicine and the Academic World 203
Index 215
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