Cellular Physiology of Nerve and Muscle / Edition 3

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Cellular Physiology of Nerve and Muscle, Third Edition offers an introduction to the basic physical and chemical principles underlying the functioning of neurons and muscle cells. The third edition of this popular text provides expanded coverage of molecular properties of ion channels and a more detailed description of neurotransmitter actions mediated via intracellular second messengers. The neural control of the heart is used as an example system in this expanded discussion. This new edition also introduces and fully discusses the actions of the autonomic nervous system. Organized in three sections, the book combines clear descriptions of difficult concepts with a series of simplified models and schematic distillations of experimental results, tailored to illustrate a particular principle. The author has also substantially expanded and updated the list of suggested readings. This book is aimed at undergraduate and medical students taking courses in physiology, neuroscience, or medical physiology.

The book contains black-and-white illustrations.

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Editorial Reviews

New edition of an introduction to the basic physical and chemical principles underlying the functioning of neurons and muscle cells. Eleven chapters cover the origin of electrical membrane potential and cellular physiology of nerve and muscle cells. They include expanded coverage of molecular properties of ion channels, neurotransmitter actions mediated via intracellular second messengers, and the actions of the autonomic nervous system. Annotation c. by Book News, Inc., Portland, Or.
Doody's Review Service
Reviewer: Mailen Kootsey, PhD (Loma Linda University)
Description: This book describes the electrical activities of nerve and muscle cells, including information about the subcellular physical and chemical processes behind the electrical events. The first edition of the book was published in 1986 and the author has revised it every five years, with the most recent revision in 1998. The fourth edition adds new material from recent research, some expansion of explanations, and new figures.
Purpose: The author's goal for this book is "a step-by-step presentation of the physical and chemical principles necessary to understand electrical signaling in cells." The author's explanations are well written and illustrated and include mathematical equations where appropriate. However, the presentation is essentially descriptive, i.e. behaviors of equations are not explored for the reader nor are there exercises to test and build the reader's understanding. The reader of this book can learn the terminologies of membrane processes, but there is modest help for a true understanding of the origins of electrical events. The book also is limited to cellular events and has little reference to electrical behaviors that result from multicellular interactions.
Audience: The author of this book does not spell out his intended audience. From the level of coverage, the book appears to be intended for students — probably at the undergraduate level or possibly as an introduction for some graduate or professional students. The author is a prominent researcher in neurophysiology and has a substantial publication record in the field.
Features: The book begins with cellular electrical processes such as electrochemical potentials and transport mechanisms. Part II covers electrical activity in nerve cells, including synaptic transmission. Finally, Part III covers electrical events in skeletal and cardiac muscle, including excitation-contraction coupling. Molecular events are successfully related to cellular behavior and the new illustrations, while not in color, contribute well to the explanations. Some quantitative concepts are expanded in appendixes. The author and publisher also provide a Web site with supplementary materials including some good color animations.
Assessment: The revisions and new material certainly add to the usefulness of this book. Students who need a description of cellular electrical processes and mechanisms will find this book readable and well illustrated. Advanced students and researchers desiring a thorough and quantitative understanding of these processes will have to look to research and review papers and more advanced texts such as Physiology of Excitable Cells, 4th edition, by Aidley (Cambridge University Press, 1998) and Mathematical Physiology by Keener and Sneyd (Springer-Verlag, 1998).

3 Stars from Doody
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Product Details

  • ISBN-13: 9780632043545
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 6/28/1998
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 272
  • Product dimensions: 7.34 (w) x 9.15 (h) x 0.56 (d)

Table of Contents

Pt. I Origin of Electrical Membrane Potential 1
1 Introduction to Electrical Signaling in the Nervous System 3
2 Composition of Intracellular and Extracellular Fluids 9
3 Maintenance of Cell Volume 17
4 Membrane Potential: Ionic Equilibrium 26
5 Membrane Potential: Ionic Steady State 40
Pt. II Cellular Physiology of Nerve Cells 55
6 Generation of Nerve Action Potential 57
7 The Action Potential: Voltage-clamp Experiments 85
8 Synaptic Transmission at the Neuromuscular Junction 110
9 Synaptic Transmission in the Central Nervous System 130
Pt. III Cellular Physiology of Muscle Cells 161
10 Excitation-Contraction Coupling in Skeletal Muscle 163
11 Neural Control of Muscle Contraction 177
12 Cardiac Muscle: The Autonomic Nervous System 188
App. A Derivation of the Nernst Equation 208
App. B Derivation of the Goldman Equation 212
App. C Electrical Properties of Cells 216
Suggested Readings 225
Index 230
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