Cellular Signal Processing: An Introduction to the Molecular Mechanisms of Signal Transduction / Edition 1

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Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease.

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Editorial Reviews

From the Publisher
"This book would be highly useful to undergraduate students in medical, bioinformatics or biological science that are studying or pursuing research into signal transduction, network or systems biology. This book would also appeal to graduate students or professionals moving into this field of research, without prior knowledge or experience....each chapter engages the reader and conveys the importance of biological systems and networks adequately, thus challenging the reader to continue viewing their specific focus or field of research in complete isolation."

Immunology News, November 2010

"This book provides comprehensive coverage of signal transduction. Unlike other texts currently available, a common theme of data processing by cellular machinery runs through this book which makes it stand out favorably against the competition. Material is up-to-date and covers the areas that are at the forefront of cell signaling research today."
Alexey Veraksa, University of Massachusetts, Boston

"The diversity of appropriate cell cycle topics covered is impressive. Impressive amount of important information. Best summary of cell cycle biochemistry in a text."
Bradley J Stith, University of Colorado

"The organization of the proposed book is excellent. The fundamentals of data processing by protein networks and evolution of this data processing in the first two chapters is the unique feature of the book and sets up the framework of cell signal transduction. This should allow students to get a firm grip of the overall pictures of cell signalling networks before zooming into the specific topics. Such chapters are largely missing from other textbooks. Figures are well executed and informative."
Wei-Jen Tang, Univesrity of Chicago

Doody's Review Service
Reviewer: Bruce A. Fenderson, PhD (Thomas Jefferson University)
Description: The 17 chapters in this comprehensive introduction to the molecular mechanisms of signal transduction cover topics ranging from the evolution of cellular data processing to cancer and the regulation of cell division. This is an exciting and clinically relevant field. The focus of the book is on cell biology and biochemistry.
Purpose: According to the authors, the goal is to provide a unifying view of cell signaling based on protein interactions. They view living cells as complex data processing machines, and they organize current research findings according to three major principles: the protein network, its energy supply, and its evolution. The authors are outstanding scientists and educators.
Audience: The book is written for undergraduate and graduate students across a wide range of life science disciplines, including cell biology, biochemistry, physiology, pharmacology, biophysics, and bioinformatics. This will be a great text to accompany an advanced undergraduate or graduate-level course in biochemistry or cell signaling. Experts will also appreciate this comprehensive review.
Features: The authors begin with metaphors to illustrate the complexity of signal processing. They view proteins as the equivalent of neurons in the central nervous system. From this perspective, proteins and their modifiers form a "cellular brain" that serves to transform input signals into output signals that regulate everything from metabolism to gene expression. Each chapter has an introduction and ends with a list of references for further reading. Short summaries are appended to each section to keep readers engaged and moving forward. The text is richly colored with red and pink highlights to focus the reader's attention on key sections. Diagrams and figures are well done. Numerous sidebars emphasize complementary perspectives and address clinical correlations. The book comes with useful ancillaries for educators, including a complete set of figures and electronic presentation files.
Assessment: Although most of these topics are covered in standard cell biology textbooks, the mechanisms of cell signaling "are so complex and interwoven, that they demand a comprehensive and focused discussion." The authors identify and carefully explain the delicate processing networks that govern intracellular and extracellular communication. These protein networks are essential for the development of life on earth. The authors succeed in organizing a rapidly growing literature on signal transduction. This book will be welcomed by students and experts alike.
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Product Details

  • ISBN-13: 9780815342151
  • Publisher: Taylor & Francis
  • Publication date: 11/30/2008
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 656
  • Product dimensions: 8.30 (w) x 10.70 (h) x 0.80 (d)

Meet the Author

Friedrich Marks, PhD, is Professor of Biochemistry at the University of Heidelberg and Emeritus Department head, German Cancer Research Center. Dr. Marks has been teaching biochemistry, in particular signal transduction, for more than 30 years. His research has focused on the role of signaling reactions in tumor development.

Ursula Klingmüller, PhD, is a lecturer at the University of Heidelberg and Head of the Systems Biology of Signal Transduction Division, German Cancer Research Center. Dr. Klingmüller's research focuses on systems biology of signal transduction and dynamic pathway modeling.

Karin Müller-Decker, PhD, is a lecturer at the University of Heidelberg and Head of the Tumor Models Units, German Cancer Research Center. Dr. Müller-Decker is conducting pioneering work on eicosanoid signaling in tumor development.

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Table of Contents

1. The "Brain of the Cell": Data Processing by Protein Networks
2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
3. Evolution of Cellular Data Processing
4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
5. Signal Transduction by Receptors with Seven Transmembrane Domains
6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
8. Gene Transcription: The Ultimate Target of Signal Transduction
9. Signals Controlling mRNA Translation
10. Signal Transduction by Small G-proteins: The Art of Molecular Targeting
11. Mitogen-activated Protein Kinase and Nuclear Factor ĸß Modules
12. Cancer and Regulation of Cell Division
13. Signal Transduction by Proteolysis and Programmed Cell Death
14. Signal Transduction by Ions
15. Sensory Signal Processing
16. Signaling at Synapses: Neurotransmitters and Their Receptors
17. Putting Together the Pieces: The Approach of Systems Biology

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