Chemical Carcinogenesis

Paperback (Softcover reprint of the original 1st ed. 1982)
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Product Details

  • ISBN-13: 9781468443363
  • Publisher: Springer US
  • Publication date: 11/28/2012
  • Series: Nato Science Series A: (closed)
  • Edition description: Softcover reprint of the original 1st ed. 1982
  • Pages: 492
  • Product dimensions: 7.00 (w) x 10.00 (h) x 1.04 (d)

Table of Contents

Section I: Chemicals as Carcinogens.- Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons.- N-Substituted Aromatic Compounds.- Metabolic Epoxidation of Aflatoxin B1 and Its Metabolites: Patterns of DNA Adduct Formation and Removal in Relation to Biological Effects.- The Problematic Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism.- Discussion.- Section II: DNA Adducts.- DNA Lesions: Nature and Genesis.- DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screeing Procedure to Identify Chemical Carcinogens.- DNA Fragmentation: Its Predictivity as a Short Term Test.- Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration.- Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepaytes Stimulated to Grow into Foci by Different Selection Procedures Identical?.- Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N1-Nitro-Guanidine.- Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance.- Discussion.- Section III: Chemicals as Promotors.- Phenobarbital and Other Liver Tumor Promotors.- Molecular Mechanisms of Multistage Carcinogenesis.- Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine.- Discussion.- Section IV: Carcinogenesis as Multistep Process.- Some Critical Consideration Concerning the Sequential Analysis of Carcinogenesis with Chemicals.- Benign and Malignant Tumor Induction in Mouse Skin.- Progress in the Study of In Vitro Neoplastic Transformation.- Pulse-Carcinogenesis by Ethylnitrosourea in the Developing Rat Nervous System: Molecular and Cellular Mechanisms.- Chromatin, Nuclei and Water: Alterations and Mechanisms for Chemically-Induced Carcinogenesic.- The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells.- Discussion.- List of Participants.- Contributor Index.

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