Chemical Synthesis of Nucleoside Analogues

( 5 )

Overview

Compiles current tested and proven approaches to synthesize novel nucleoside analogues

Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a ...

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Overview

Compiles current tested and proven approaches to synthesize novel nucleoside analogues

Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:

  • Changes to the heterocyclic base
  • Modification of substituents at the sugar ring
  • Replacement of the furanose ring by a different carbo- or heterocyclic ring
  • Introduction of conformational restrictions
  • Synthesis of enantiomers
  • Preparation of hydrolitically stable C-nucleosides

Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.

Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.

Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

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Product Details

  • ISBN-13: 9781118007518
  • Publisher: Wiley
  • Publication date: 3/18/2013
  • Edition number: 1
  • Pages: 912
  • Product dimensions: 6.30 (w) x 9.40 (h) x 2.00 (d)

Meet the Author

PEDRO MERINO, PhD, is the Director of the Department of Synthesis and Structure of Biomolecules of the Institute of Chemical Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr. Merino has authored more than 200 publications, including several reviews and book chapters. His research spans asymmetric synthesis, target-oriented synthesis, organometallic chemistry, and asymmetric metal-assisted and organic catalysis. Recently, he has been investigating the use of computational chemistry to better understand reaction mechanisms.

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Table of Contents

Contributors ix

Foreword xiii

Preface xv

1 Biocatalytic Methodologies for Selective Modified Nucleosides 1
Miguel Ferrero, Susana Fernández, and Vicente Gotor

2 Nucleosides Modified at the Base Moiety 49
O. Sari, V. Roy, and L. A. Agrofoglio

3 Chemical Synthesis of Acyclic Nucleosides 103
Hai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu

4 Phosphonated Nucleoside Analogues 163
Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio

5 Chemical Syntheses of Nucleoside Triphosphates 209
Lina Weinschenk and Chris Meier

6 Mononucleotide Prodrug Synthetic Strategies 229
Suzanne Peyrottes and Christian Périgaud

7 Synthesis of C-Nucleosides 263
Omar Boutureira, M. Isabel Matheu, Yolanda Dá?az, and Sergio Castillón

8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317
Maurice Okello and Vasu Nair

9 Synthesis of Conformationally Constrained Nucleoside Analogues 345
Esma Maougal, Jean-Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton

10 Synthesis of 3-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427
Mará?a-José Camarasa, Sonsoles Velázquez, Ana San-Félix, and Mará?a-Jesáus Pérez-Pérez

11 l-Nucleosides 473
Daniela Perrone and Massimo L. Capobianco

12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535
E. Leclerc

13 Uncommon Three-, Four-, and Six-Membered Nucleosides 605
E. Groaz and P. Herdewijn

14 Recent Advances in Synthesis and Biological Activity of 4-Thionucleosides 655
Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong

15 Recent Advances in the Chemical Synthesis of Aza-Nucleosides 699
Tomás Tejero, Ignacio Delso, and Pedro Merino

16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727
D. D’Alonzo and A. Guaragna

17 Isoxazolidinyl Nucleosides 781
Ugo Chiacchio, Antonino Corsaro, Salvatore Giofre, and Giovanni Romeo

18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819
Apurba Datta

19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847
Pedro Merino and Rosa Matute

Index 881

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  • Anonymous

    Posted January 3, 2014

    New charcter to add {PLEASE ADD}

    Child of demeter. He is 13. Blonde hair with a black streak that goes above his eyes. His eyes are brown tinged with blue green and white. Uses a belt of throwing daggers and two hooked swords. Shy but loyal to friends

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  • Anonymous

    Posted December 29, 2013

    Sweet Death

    Is patiently waiting XD

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  • Anonymous

    Posted December 22, 2013

    STARSTRUCK CONTINUE!!!!

    I KNOW WHERE YOU LIVE AND WHERE YOU SLEEP!!!!!!!

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  • Anonymous

    Posted December 22, 2013

    Diana

    That's a little creepy... but I do too! You sleep in a bed and you live in the universe. XD

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