Chemical Synthesis of Nucleoside Analogues

Chemical Synthesis of Nucleoside Analogues

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by Pedro Merino
     
 

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Compiles current tested and proven approaches to synthesize novel nucleoside analogues

Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new

Overview

Compiles current tested and proven approaches to synthesize novel nucleoside analogues

Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:

  • Changes to the heterocyclic base
  • Modification of substituents at the sugar ring
  • Replacement of the furanose ring by a different carbo- or heterocyclic ring
  • Introduction of conformational restrictions
  • Synthesis of enantiomers
  • Preparation of hydrolitically stable C-nucleosides

Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.

Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.

Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

Product Details

ISBN-13:
9781118498101
Publisher:
Wiley
Publication date:
02/12/2013
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
912
File size:
53 MB
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Meet the Author

PEDRO MERINO, PhD, is the Director of the Department of Synthesis and Structure of Biomolecules of the Institute of Chemical Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr. Merino has authored more than 200 publications, including several reviews and book chapters. His research spans asymmetric synthesis, target-oriented synthesis, organometallic chemistry, and asymmetric metal-assisted and organic catalysis. Recently, he has been investigating the use of computational chemistry to better understand reaction mechanisms.

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Chemical Synthesis of Nucleoside Analogues 5 out of 5 based on 0 ratings. 2 reviews.
Anonymous More than 1 year ago
That's a little creepy... but I do too! You sleep in a bed and you live in the universe. XD
Anonymous More than 1 year ago
Fluggernugget