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Doody's Review ServiceReviewer: Yu-Kun Jennifer Zhang, PhD (University of Kansas Medical Center)
Description: Chemokine signaling pathways play an important role in the development of various diseases, including AIDS, autoimmune diseases, and cancer. This volume in the Methods and Principles of Medicinal Chemistry series discusses fundamental and pathophysiological aspects of chemokines and their receptors as related to the discovery of drugs targeting these pathways for the treatment of diseases.
Purpose: The main purpose is to delineate chemokine receptors as potential drug targets. Chemokine receptors are recognized by both academia and the pharmaceutical industry as valuable targets for therapeutic intervention in a variety of major diseases. This well-organized book presents the full spectrum of knowledge in the field.
Audience: It will be of interest to researchers, students, and clinicians working in the areas of inflammatory diseases, autoimmune diseases, and oncology. The editors are well-known experts in chemokine research and the authors of each chapter are recognized for their expertise.
Features: The book's three sections address the up-to-date knowledge about chemokines and their receptors, diseases caused by disorders in chemokine receptors, and drugs targeting chemokine receptors. It provides a comprehensive summary of the role of chemokines and their receptors in a variety of diseases such as heart disease, asthma, arthritis, cancer, and AIDS. More importantly, this book is unique in that it provides a collection of examples of drugs or drug candidates for antagonizing several important chemokine receptors. A shortcoming is that figure formatting and coloring are not uniform throughout the book. For example, similar structure figures appear in color in chapter 2, but not in chapter 1. Some figures and tables are too crowded (i.e., Figure 10.2), whereas others are relatively empty (i.e., Table 15.1).
Assessment: This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases. The comprehensive summary of drugs antagonizing chemokine receptors, not found in other books, makes this a very useful reference for those involved in the development of these novel drugs.