Chemokine Receptors as Drug Targets / Edition 1

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Overview

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

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Editorial Reviews

Doody's Review Service
Reviewer: Yu-Kun Jennifer Zhang, PhD (University of Kansas Medical Center)
Description: Chemokine signaling pathways play an important role in the development of various diseases, including AIDS, autoimmune diseases, and cancer. This volume in the Methods and Principles of Medicinal Chemistry series discusses fundamental and pathophysiological aspects of chemokines and their receptors as related to the discovery of drugs targeting these pathways for the treatment of diseases.
Purpose: The main purpose is to delineate chemokine receptors as potential drug targets. Chemokine receptors are recognized by both academia and the pharmaceutical industry as valuable targets for therapeutic intervention in a variety of major diseases. This well-organized book presents the full spectrum of knowledge in the field.
Audience: It will be of interest to researchers, students, and clinicians working in the areas of inflammatory diseases, autoimmune diseases, and oncology. The editors are well-known experts in chemokine research and the authors of each chapter are recognized for their expertise.
Features: The book's three sections address the up-to-date knowledge about chemokines and their receptors, diseases caused by disorders in chemokine receptors, and drugs targeting chemokine receptors. It provides a comprehensive summary of the role of chemokines and their receptors in a variety of diseases such as heart disease, asthma, arthritis, cancer, and AIDS. More importantly, this book is unique in that it provides a collection of examples of drugs or drug candidates for antagonizing several important chemokine receptors. A shortcoming is that figure formatting and coloring are not uniform throughout the book. For example, similar structure figures appear in color in chapter 2, but not in chapter 1. Some figures and tables are too crowded (i.e., Figure 10.2), whereas others are relatively empty (i.e., Table 15.1).
Assessment: This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases. The comprehensive summary of drugs antagonizing chemokine receptors, not found in other books, makes this a very useful reference for those involved in the development of these novel drugs.
From the Publisher
"This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases." (Doody's, 14 October 2011)

"This book covers chemokine receptors more thoroughly than any other that I have seen to date. This is an ideal text for researchers seeking to understand the full spectrum of chemokine receptor biology, recent and historical progress towards receptor inhibitors, and insights and perspectives for future research directions." (ChemMedChem, 1 August 2011)

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Product Details

Meet the Author

The editors are based at the Amsterdam Center for Drug Research, a cross-disciplinary center in the Dutch academic system, but with numerous ties to pharmaceutical companies.

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Table of Contents

FUNDAMENTALS OF CHEMOKINES AND CHEMOKINE RECEPTORS
Structural Aspects of Chemokines, and their Interactionss with Receptors and GAGs
Structural Insights for Homology Modeling of Chemokine Receptors
Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration
The Atypical Chemokine Receptors
Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?
CHEMOKINE RECEPTORS IN DISEASE
Chemokine Receptors in Inlammatory Diseases
Chemokines and their Receptors in Central Nervous System Disease
Chemokines and Cancer Metastasis
Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis
TARGETING CHEMOKINE RECEPTORS
CCR5 Antagonists in HIV
CXCR4 as therapeutic target
Low-Molecular Weight CXCR2 Antagonists as Promising Therapeutics
Therapeutic Targeting of the CXCR3 Receptors
Targeting CCR1
Targeting CCR3
Chemokine-Binding Proteins as Therapeutics

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