Chemokine Receptors as Drug Targets, Volume 46 by Martine J. Smit | NOOK Book (eBook) | Barnes & Noble
Chemokine Receptors as Drug Targets, Volume 46

Chemokine Receptors as Drug Targets, Volume 46

by Martine J. Smit
     
 

View All Available Formats & Editions

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference

Overview

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Editorial Reviews

Doody's Review Service
Reviewer: Yu-Kun Jennifer Zhang, PhD (University of Kansas Medical Center)
Description: Chemokine signaling pathways play an important role in the development of various diseases, including AIDS, autoimmune diseases, and cancer. This volume in the Methods and Principles of Medicinal Chemistry series discusses fundamental and pathophysiological aspects of chemokines and their receptors as related to the discovery of drugs targeting these pathways for the treatment of diseases.
Purpose: The main purpose is to delineate chemokine receptors as potential drug targets. Chemokine receptors are recognized by both academia and the pharmaceutical industry as valuable targets for therapeutic intervention in a variety of major diseases. This well-organized book presents the full spectrum of knowledge in the field.
Audience: It will be of interest to researchers, students, and clinicians working in the areas of inflammatory diseases, autoimmune diseases, and oncology. The editors are well-known experts in chemokine research and the authors of each chapter are recognized for their expertise.
Features: The book's three sections address the up-to-date knowledge about chemokines and their receptors, diseases caused by disorders in chemokine receptors, and drugs targeting chemokine receptors. It provides a comprehensive summary of the role of chemokines and their receptors in a variety of diseases such as heart disease, asthma, arthritis, cancer, and AIDS. More importantly, this book is unique in that it provides a collection of examples of drugs or drug candidates for antagonizing several important chemokine receptors. A shortcoming is that figure formatting and coloring are not uniform throughout the book. For example, similar structure figures appear in color in chapter 2, but not in chapter 1. Some figures and tables are too crowded (i.e., Figure 10.2), whereas others are relatively empty (i.e., Table 15.1).
Assessment: This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases. The comprehensive summary of drugs antagonizing chemokine receptors, not found in other books, makes this a very useful reference for those involved in the development of these novel drugs.
From the Publisher
"This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases." (Doody's, 14 October 2011)

"This book covers chemokine receptors more thoroughly than any other that I have seen to date. This is an ideal text for researchers seeking to understand the full spectrum of chemokine receptor biology, recent and historical progress towards receptor inhibitors, and insights and perspectives for future research directions." (ChemMedChem, 1 August 2011)

Product Details

ISBN-13:
9783527632343
Publisher:
Wiley
Publication date:
12/07/2010
Series:
Methods and Principles in Medicinal Chemistry , #46
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
384
File size:
3 MB

Meet the Author

The editors are based at the Amsterdam Center for Drug Research, a cross-disciplinary center in the Dutch academic system, but with numerous ties to pharmaceutical companies.

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >