Chemometric Methods in Capillary Electrophoresis / Edition 1

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Overview

Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses

For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development.

Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE.

Part 1 discusses differing types of screening designs and response surface methodology—in an¿application based format

Part 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studies

Part 3 provides practical information on modelling quantitative structure relationships

Part 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform Electrophoresis

Showing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.

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Editorial Reviews

From the Publisher
"This book can be used as an initial desktop reference for chemometric applications for CE but readers interested in more in-depth applications of such techniques will need other chemometrics textbooks . . . The concise presentation of the chemometric methods and their application to CE-relevant data makes the content with this book quite accessible to the novice and provides a valuable data analysis resource for the practicing CE analyst." (Anal Bioanal Chem, 2010)
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Product Details

  • ISBN-13: 9780470393291
  • Publisher: Wiley
  • Publication date: 11/23/2009
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 435
  • Product dimensions: 6.00 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

Grady Hanrahan, PhD, received his doctorate in environmental analytical chemistry from the University of Plymouth, England. Dr. Hanrahan is currently the John Stauffer Endowed Professor of Analytical Chemistry at California Lutheran University with research interests in the use of modern chemometric methods in the design and development of environmental and bioanalytical instrumentation. He is also exploring the use of neural and evolutionary computational techniques for solving complex chemical problems.

Frank A. Gomez, PhD, received his BS in chemistry from California State University, Los Angeles (CSULA), and his PhD in chemistry from UCLA, where he was a NIH Predoctoral Fellow. From 1991–1994, he was a Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow in the department of chemistry at Harvard University. He is a professor of chemistry at CSULA and is a visiting associate at Caltech in the Applied Physics department.

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Table of Contents

Preface ix

Acknowledgments xi

Editor Biographies xii

Contributors xv

Key acronyms xix

I Experimental Design And Optimization Considerations 1

1 Introduction Grady Hanrahan Frank A. Gomez 3

2 Experimental Design In Method Optimization And Robustness Testing Bieke Dejaegher Alexandra Durand Yvan Vander Heyden 11

3 Chemometrical Experimental Design-based Optimization Studies In Capillary Electrophoresis Applications Ruthy Montes Toni Ann Riveros Froseen Dahdouh Grady Hanrahan Frank A. Gomez 75

4 Application Of Chemometric Methods In Drug Purity Determination By Capillary Electrophoresis Gerhard K.E. Scriba 93

5 Optimization Of Micellar Electrokinetic Chromatography Separation Conditions By Chemometric Methods Jessica L. Felhofer Carlos D. Garcia 113

6 Chemometric Methods For The Optimization Of Ce And Ce-Ms In Pharmaceutical, Environmental, And Food Analysis Javier Hernández-Borges Miguel Ángel Rodriguez-Delgado Alejandro Cifuentes 133

7 Optimization Of The Separation Of Amino Acids By Capillary Electrophoresis Using Artificial Neural Networks Amanda Van Gramberg Alison Beavis Lucas Blanes Philip Doble 169

II Exploratory Data Analysis, Prediction, And Classification 181

8 Development Of Capillary Electrophoresis Fingerprints And Multivariate Statistics For The Differentiation Of Opium And Poppy Straw Samples Raymond G. Reid Susanne P. Boyle Ann S. Low David G. Durham 183

9 Multivariate Curve Resolution Based On Alternating Least Squares In Capillary Electrophoresis Javier Saurina 199

10 Application Of Chemometrics In Capillary Electrophoresis Analysis Of Herbal Medicines Shao-Ping Li Xiao-Jia Chen Feng-Qing Yang 227

11 Clinical PatternRecognition Analysis Applying Artificial Neural Networks Based On Principal Component Analysis Input Selection Yaxiong Zhang Hua Li 243

12 Chemometric Methods Applied To Genetic Analyses By Capillary Electrophoresis And Electrophoresis Microchip Technologies Maribel Elizabeth Funes-Huacca Juliana Vieira Alberice Lucas Blanes Emanuel Carrilho 261

13 Exploratory Data Analysis And Classification Of Capillary Electrophoretic Data Melanie Dumarey Bieke Dejaegher Alexandra Durand Yvan Vander Heyden 291

III Quantitative Structure Relationships 323

14 Chemometrical Modeling Of Electrophoretic Mobilities In Capillary Electrophoresis Mehdi Jalali-Heravi 325

15 Assessment Of Solute-Micelle Interactions In Electrokinetic Chromatography Using Quantitative Structure-Retention Relationships Edgar P. Moraes Fernando G. Tonin Luís G. Dias Jo&atild;o P.S. Farah Marina P.M. Tavares 345

16 Chemometrical Analysis Of Cheese Proteolysis Profiles By Capillary Electrophoresis: Prediction Of Ripening Times Natividad Ortega Silvia M. Albillos Maria D. Busto 367

IV Transformation Techniques 389

17 Transformation Techniques For Capillary And Microchip Electrophoresis Takashi Kaneta 391

Index 407

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