Chemoreception: From Cellular Signaling to Functional Plasticity / Edition 1

Chemoreception: From Cellular Signaling to Functional Plasticity / Edition 1

by Jean-Marc Pequignot

Proceedings of the XVth International Symposium on Arterial Chemoreception held, November 18-22, 2002, in Lyon, France.
During the last decade the fascinating field of oxygen-sensing has evolved from the findings of further oxygen sensing cells both in peripheral and central tissues, of molecules and channels implicated in chemoreception, and of transcriptional

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Proceedings of the XVth International Symposium on Arterial Chemoreception held, November 18-22, 2002, in Lyon, France.
During the last decade the fascinating field of oxygen-sensing has evolved from the findings of further oxygen sensing cells both in peripheral and central tissues, of molecules and channels implicated in chemoreception, and of transcriptional factors controlling the expression of a number of genes involved in physiological responses to hypoxia. In order to take into account these new aspects of chemoreception, this volume presents a multidisciplinary approach at the interface of cellular, molecular biology and integrative physiology with the main objective to elucidate the chemosensory processes and associated cardiorespiratory functions in hypoxic/hypercapnic environmental conditions.
Specifically, the volume presents up to date major aspects of the chemoreceptor pathway from molecular and cellular signalling processes in the carotid body and other oxygen-sensing structures to central integration of chemosensory inputs and systemic implications. Because sustained changes in oxygen homeostasis are able to induce morphofunctional remodeling which remains poorly understood but may provide further ways of research in physiology and pathophysiology, two sessions were devoted to the mechanisms involved in the processes of plasticity induced by long-term or intermittent hypoxia during the perinatal period or at adulthood.

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Product Details

Springer US
Publication date:
Advances in Experimental Medicine and Biology Series, #536
Edition description:
Product dimensions:
10.00(w) x 7.00(h) x 1.44(d)

Table of Contents

Honoring Pierre Dejours. His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans; H. Gautier.
O2 and CO2 Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events. 2P Domain K+ Channels: Novel Pharmacological Targets for Volatile General Anesthetics; A.J. Patel, E. Honore. Ca2+ Responses to Hypoxia are Mediated by IP3-R on Ca2+ Store Depletion; S. Lahiri, et al. Functional Identification of Kvalpha Subunits Contributing to the O2-sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells; J.R. López-López, et al. Carotid Body Chemoreceptor Activity in Mice Deficient in Selected Subunits of NADPH Oxidase ; L. He, et al. Glucose Sensing Cells in the Carotid Body; M. Garcia-Fernandez, et al. Effect of Mihondrial Inhibitors on Type I Cells; C.N. Wyatt, K.J. Buckler. Ascorbate in the Carotid Body; A. Dymecka, et al. Studies on Glomus Cell Sensitivity to Hypoxia in Carotid Body Slices; P. Ortega-Sáenz, et al. An Unusual Cyhrome a592 with low PO2 Affinity Correlates with Afferent Discharge in the Carotid Body; C. Huckstorf et al. A Reevaluation of the Mechanisms Involved in the Secretion of Catecholamine Evoked by 2.4 Dinitrophenol From Chemoreceptors Cells of the Rabbit Carotid Body; A. Rocher, et al. Enhancing Effect of Vasopressin on the Hyperglycaemic Response to Carotid Body Chemoreceptor Stimulation. 6 Additional Articles.
O2 and CO2 Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: Membrane Properties, Intracellular Metabolic and Genomic Events. Pulmonary Interstitium: an Introductory Review; G. Miserocchi. Regulation of K+ Currents by CO in Carotid Body Type 1 Cells and Pulmonary Artery Smooth Muscle Cells; P. Kumar, et al. Ionotropic Receptors in Pulmonary Neuroepithelial Bodies (NEB) and their Possible Role in Modulation of Hypoxia Signalling; E. Cutz, et al. Mihondrial Complex II is Essential for Hypoxia-induced ROS Generation and Vasoconstriction in the Pulmonary Vasculature; R. Paddenberg, et al. Regulation of the Hypoxia-inducible Transcription Factor HIF-1 by Reactive Oxygen Species in Smooth Muscle Cells; S. BelAiba, A. Görlach. O2-sensing Mechanisms in Efferent Neurons to the Rat Carotid Body; V.A. Campanucci, et al. Amyloid Peptide-mediated Hypoxic Regulation of Ca2+ Channels in PC12 Cells; C. Peers, et al. Role of ROS and NO in Hypoxia-induced Increase in Tyrosine Hydroxylase-messenger RNA in PC12 Cells; W. Kummer, et al. Oxygen Sensing by Human Recombinant Tandem-P Domain Potassium Channels; P.J. Kemp, et al. Oxygen Sensing by Human Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Acute Hypoxia; P.J. Kemp, et al. Potential Oxygen Sensing Pathways in the Zebrafish Gill; M.G.Jonz, et al. 3 Additional Articles.
Mechanisms of Communication Between Chemosensory Cells and Chemoafferent Fibers. Dye and Electric Coupling Between Carotid Nerve Terminals and Glomus Cells; R.G. Jiang, C. Eyzaguirre. Neurotransmitter Relationships in the Hypoxia-challenged Cat Carotid Body; R.S. Fitzgerald, et al.Ach Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Mice; S. Yamaguchi, et al. Hypoxic Augmentation of Neuronal Nicotinic Acetylcholine Receptors and Carotid Body Function; M. Shirahata, et al. Cholinergic Actions on Carotid Chemosensory System; P. Zapata, et al. Nicotinic Acetylcholine Receptor Channels in Cat Chemoreceptor Cells; T. Higashi, et al. Hypoxia Does Not Uniformly Facilitate The Release of Multiple Transmitters from the Carotid Body; Dong-Kyu Kim, et al. Expression and Function of Pre-synaptic Neurotransmitter Receptors in the Chemoafferent Pathway of the Rat Carotid Body; I.M. Fearon, et al. Adenosine-Acetylcholine Interactions at the Rat Carotid Body; S.V. Conde, E.C. Monteiro. Diverse Cholinergic Receptors in the Cat Carotid Chemosensory Unit; S. Hirasawa, et al. Carotid Chemosensory Neurons in the Petrosal Ganglia are Excited by Ach and ATP; R. Varas, et al. The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function; A.J. Rico, et al. Concomitant Effect of Acetylcholine and Dopamine on Carotid Chemosensory Activity in Catecholamine Depleted Cats; A. Bairam, Y. Lajeunesse. 4 Additional Articles.
Brainstem O2 and CO2 Sensing - Central Integration of Peripheral Chemosensory Inputs. Chemosensitivity of Medullary Respiratory Neurones. A Role for Ionotropic P2X and GABAA Receptors; A.V. Gourine, K.M. Spyer. Effects of Controller Dynamics on Stimulations of Irregular and Periodic Breathing; G.S. Longobardo, et al. CO2 /H+ Signal Tranduction and Central Ventilatory Control; H. Kazemi. Differential Expression of Intracellular Acidosis in Rat Brainstem Regions in Response to Hypercapnic Ventilation; J.C. LaManna, et al. Tentative Role of the Na+/H+ Exchanger Type 3 in Central Chemosensitivity of Respiration; H. Kiwull-Schöne, et al. Effect of Losartan Microinjections into the NTS on the Cardiovascular Components of Chemically Evoked Reflexes in a Rabbit Model of Acute Heart Ischemia; L. Rosario, et al. Effects of Acute Hypoxic Conditions on Extracellular Excitatory Amino Acids and Dopamine in the Striatum of Freely-moving Rats; S. Parrot, et al. Activity of Dorsal Medullary Respiratory Neurons in Awake Rats; F.P. Martial, et al. Cardiovascular and Respiratory Responses to Heme Oxygenase Inhibition in Conscious Rats; H. Hirakawa, et al. Peripheral Chemoreceptor Input to Cardiac Vagal Preganglionic Neurons in the Anaesthetized Rat; D.M. O'Leary, J.F.X. Jones. Hypoxic Remodelling of Ca2+ Homeostasis in Rat Type 1 Cortical Astrocytes; C. Peers, et al. Effect of CO2 on Cardiovascular Regulation in Conscious Rats; S. Oikawa, et al. A6 noradrenergic cell group modulates the hypoxic ventilatory response; C. Soulage, et al. Ventilatory Chemosensory Drive in Cats, Rats and Guinea Pigs; R. Fernandez, et al.
Plasticity of Chemosensitivity Processes During Development: Transition at Birth and Delayed Effects. Deletion of Tachykinin NK1 Receptor Gene in Mice Does Not Alter Respiratory Network Maturation but Alters Respiratory Responses to Hypoxia; G. Hilaire, et al. Autonomic Ganglion Cells: Likely Source of Acetylcholine in the Rat Carotid Body; E.B. Gauda, et al. Effects of Perinatal Hyperoxia on Carotid Body Chemoreceptors Activity in vitro; J. Prieto-Lloret, et al. Prenatal Hypoxia and Early Postnatal Maturation of the Chemoafferent Pathway; J. Peyronnet, et al. pH Sensitivity of Spinal Cord Rhythm in Fetal Mice in vitro; J. Eugenin, et al. Time Dependent Regulation of Dopamine D1- and D2 -Receptor Gene Expression in the Carotid Body of Developing Rabbits by Hypoxia; A. Bairam, et al. Ventilatory Response to CO2 in New-born Mouse; M.C. Ordenes, et al. Long-term Effects of Neonatal Cryoanesthesia on Hypoxic Ventilatory Response in Weaning Rats Depend on Neonatal Testosterone; V. Joseph, et al.
Plasticity of Chemosensitive Processes: Acclimatization to Intermittent Versus Chronic Hypoxia in Adult Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mihondrial Dysfunction; Y. Peng, et al. Effects of Hypobaric Hypoxia on the Intercellular Coupling of Glomus Cells; G.R. Jiang, C. Eyzaguirre. Oxygen Sensing by Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Chronic Hypoxia; P.J. Kemp, et al. Altered Expression of Vascular Endothelial Growth Factor and FLK-1 Receptor in Chronically Hypoxic Rat Carotid Body; J. Chen, et al. Role of HIF-1 in Physiological Adaptation of the Carotid Body During Chronic Hypoxia; Man-Lung Fung, G.L. Tipoe. Carotid body HIF-1α, VEGF and NOS Expression During Aging and Hypoxia; C. Di Giulio, et al. Rat Carotid Bodies in Systemic Hypoxia. Involvement of Arterial CO2 Tension in Morphological Changes; T. Kusakabe, et al. Immunohishemical Study of the Carotid Body Just After Arousal From Hibernation; K. Fukuhara, et al.

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