Chirality in Industry II: Development in the Commercial Manufacture of Optically-Active Compounds

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Chirality describes the pharmacological, biological, and chemical consequences of molecular symmetry. This book presents an industrial rather than academic approach to chirality, allowing readers to apply it to the manufacture and commercialization of optically active products. This second volume includes important case histories and expert views from regulatory bodies. It covers antiviral nucleosides, chiral liquid crystals, membrane technology for racemate separation and all aspects of the scale-up and ...
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New York 1997 Hardcover Very Good Ex-Library Condition 8vo-over 7?-9?" tall Covers: chiral drugs; production methods for chiral non-steroidal anti-inflammatory profen drugs; ... synthesis of enantiometically pure nucleosides; rational design in resolutions; resolution versus stereoselective synthesis in drug development; crystal science techniques in the manufacture of chiral compounds; membrane separations in the production of optically pure compounds; four case studies in the development of biotransformation-based processes; (S)-2-chloropropanoic acid; development of a full scale process for a chiral pyrrolidine; development of a muylti-stage chemical and biological process for an optically active intermediate for an anti-glaucoma drug; synthesis and applications of chiral liquid crystals; biotransformation in the production of l-carnitine; asymmetric hydrocyanation of vinylarenes; enantioselective protonation in fragrance synthesis; thiamphenical; sharpless asymmetric spoxidation; asymmetric synthesis of su Read more Show Less

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Overview

Chirality describes the pharmacological, biological, and chemical consequences of molecular symmetry. This book presents an industrial rather than academic approach to chirality, allowing readers to apply it to the manufacture and commercialization of optically active products. This second volume includes important case histories and expert views from regulatory bodies. It covers antiviral nucleosides, chiral liquid crystals, membrane technology for racemate separation and all aspects of the scale-up and manufacture of optically active intermediates and products.
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Product Details

  • ISBN-13: 9780471966807
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 3/11/1997
  • Edition number: 1
  • Pages: 418
  • Product dimensions: 6.22 (w) x 9.33 (h) x 1.26 (d)

Table of Contents

List of Contributors
Foreword
Preface
Acknowledgements
1 Introduction 1
2 Chiral Drugs: Regulatory Aspects 11
3 Production Methods for Chiral Non-steroidal Anti-inflammatory Profen Drugs 19
4 Synthesis of Enantiomerically Pure Nucleosides 41
5 Rational Design in Resolutions 81
6 Resolution Versus Stereoselective Synthesis in Drug Development: Some Case Histories 99
7 Crystal Science Techniques in the Manufacture of Chiral Compounds 119
8 Membrane Separations in the Production of Optically Pure Compounds 157
9 Four Case Studies in the Development of Biotransformation-based Processes 183
10 (S)-2-Chloropropanoic Acid: Developments in its Industrial Manufacture 207
11 Development of a Full-scale Process for a Chiral Pyrrolidine 225
12 Development of a Multi-stage Chemical and Biological Process for an Optically Active Intermediate for an Anti-glaucoma Drug 245
13 Synthesis and Applications of Chiral Liquid Crystals 263
14 Bio-transformation in the Production of L-Carnitine 287
15 Asymmetric Hydrocyanation of Vinylarenes 309
16 Enantioselective Protonation in Fragrance Synthesis 335
17 Thiamphenicol: a Manufacturing Process Involving a Double Inversion of Stereochemistry 353
18 Sharpless Asymmetric Epoxidation: Scale-up and Industrial Production 363
19 Asymmetric Synthesis of Sulphoxides: Two Case Studies 381
20 Asymmetric Reduction of Prochiral Ketones 391
Index 403
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