Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

by F.J. Alvarez-Leefmans
     
 

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This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion

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Overview

This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther­ modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem­ brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener­ alized and virtually all cells were thought to have a very high P Cl and a ther­ modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

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Editorial Reviews

Booknews
This book grew from a workshop held under the auspices of the Second World Congress of Neuroscience (IBRO) in Budapest, Aug. 1987. Contributors were asked to expand their research presentation to include not just their own findings but to put all relevant findings into a perspective. The result is a highlighting of current hot spots of interest in a field that is entering its logarithmic growth phase. Coverage is of chloride carriers--methods for measuring chloride transport, principles of cell volume regulation, synaptic inhibition; and different types of chloride channels--transmitter-activated anion channels, calcium-dependent, voltage-activated. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9780306434266
Publisher:
Springer US
Publication date:
02/07/2008
Edition description:
1990
Pages:
426
Product dimensions:
10.00(w) x 7.00(h) x 1.00(d)

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