Cholesterol Binding and Cholesterol Transport Proteins:: Structure and Function in Health and Disease

by J. Robin Harris (Editor)

Overview

Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders.

It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.

Product Details

ISBN-13:	9789048186211
Publisher:	Springer Netherlands
Publication date:	03/17/2010
Series:	Subcellular Biochemistry , #51
Edition description:	2010
Pages:	631
Product dimensions:	6.10(w) x 9.20(h) x 1.60(d)

Table of Contents

1 Cholesterol-Protein Interaction: Methods and Cholesterol Reporter Molecules Gerald Gimpl 1

2 Cholesterol in Alzheimer's Disease and other Amyloidogenic Disorders J. Robin Harris Nathaniel G.N. Milton 47

3 Cholesterol-Binding Viral Proteins in Virus Entry and Morphogenesis Cornelia Schroeder 77

4 Sterol-Protein Interactions in Cholesterol and Bile Acid Synthesis Emma De Fabiani Nico Mitro Federica Gilardi Maurizio Crestani 109

5 Cholesterol Oxidase: Structure and Function Alice Vrielink 137

6 Oxysterol-Binding Proteins Neale D. Ridgway 159

7 High Density Lipoprotein Structure-Function and Role in Reverse Cholesterol Transport Sissel Lund-Katz Michael C. Phillips 183

8 Lipoprotein Modification and Macrophage Uptake: Role of Pathologic Cholesterol Transport in Atherogenesis Yury I. Miller Soo-Ho Choi Longhou Fang Sotirios Tsimikas 229

9 Cholesterol Interaction with Proteins That Partition into Membrane Domains: An Overview Richard M. Epand Annick Thomas Robert Brasseur Raquel F. Epand 253

10 Caveolin, Sterol Carrier Protein-2, Membrane Cholesterol-Rich Microdomains and Intracellular Cholesterol Trafficking Friedhelm Schroeder Huan Huang Avery L. McIntosh Barbara P. Atshaves Gregory G. Martin Ann B. Kier 279

11 Cholesterol in Niemann-Pick Type C disease Xiaoning Bi Guanghong Liao 319

12 Protein Mediators of Sterol Transport Across Intestinal Brush Border Membrane J. Mark Brown Liqing Yu 337

13 Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases Teruo Hayashi Tsung-Ping Su 381

14 Prominin-1: A Distinct Cholesterol-Binding Membrane Protein and the Organisation of the Apical Plasma Membrane of Epithelial Cells Denis Corbeil Anne-Marie Marzesco Christine A. Fargeas Wieland B. Huttner 399

15 Mammalian StAR-Related Lipid Transfer (START) Domains with Specificity for Cholesterol: Structural Conservation and Mechanism of Reversible Binding Pierre Lavigne Rafael Najmanivich Jean-Guy LeHoux 425

16 Membrane Cholesterol in the Function and Organization of G-Protein Coupled Receptors Yamuna Devi Paila Amitabha Chattopadhyay 439

17 Cholesterol Effects on Nicotinic Acetylcholine Receptor: Cellular Aspects Francisco J. Barrantes 467

18 Cholesterol and Myelin Biogenesis Gesine Saher Mikael Simons 489

19 Cholesterol and Ion Channels Irena Levitan Yun Fang Avia Rosenhouse-Dantsker Victor Romanenko 509

20 The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins Alejandro P. Heuck Paul C. Moe Benjamin B. Johnson 551

21 Cholesterol Specificity of Some Heptamcric β-Barrel Pore-Forming Bacterial Toxins: Structural and Functional Aspects J. Robin Harris Michael Palmer 579

22 Cholesterol-Binding Toxins and Anti-cholesterol Antibodies as Structural Probes for Cholesterol Localization Yoshiko Ohno-Iwashita Yukiko Shimada Masami Hayashi Machiko Iwamoto Shintaro Iwashita Mitsushi Inomata 597

Index 623