Chromosomal Translocations and Oncogenic Transcription Factors

Overview

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives ...

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Overview

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Roger W. Melvold, PhD (Northwestern University Feinberg School of Medicine)
Description: This volume of Current Topics in Microbiology and Immunology is devoted to the molecular and biochemical bases for mutational changes in cellular transcription factors that result in uncontrolled growth and malignancy.
Purpose: Ten chapters contributed by 18 authors cover a wide range of types of transcription factors, representing basically all the major classes, and biochemical activities (e.g., localization, affinity, protein-protein interaction, potency) altered by these events. The types of chromosomal rearrangements that lead to the truncations or inappropriate gene fusions are also discussed.
Audience: The volume is directed toward specialists, particularly cancer researchers and molecular geneticists, but the chapters are also accessible to students and others who are not already conversant in the subject matter.
Features: There are numerous black-and-white drawings and photomicrographs that help illustrate the chromosomal translocations and functional alterations involved. They are well done and informative. The chapters all include current references up through 1995, although the length of the reference lists varies substantially among them. The contributing authors are well recognized, and the volume is a valuable overview of the current state of knowledge in a topic of great relevance in understanding the bases for an important area of human disease.
Assessment: The preface is unusually informative in setting out the goals of the volume and the contents and relevance of the chapters that follow, and it would be a valuable addition to libraries and to the targeted cancer researchers and molecular geneticists.
Roger W. Melvold
This volume of Current Topics in Microbiology and Immunology is devoted to the molecular and biochemical bases for mutational changes in cellular transcription factors that result in uncontrolled growth and malignancy. Ten chapters contributed by 18 authors cover a wide range of types of transcription factors, representing basically all the major classes, and biochemical activities (e.g., localization, affinity, protein-protein interaction, potency) altered by these events. The types of chromosomal rearrangements that lead to the truncations or inappropriate gene fusions are also discussed. The volume is directed toward specialists, particularly cancer researchers and molecular geneticists, but the chapters are also accessible to students and others who are not already conversant in the subject matter. There are numerous black-and-white drawings and photomicrographs that help illustrate the chromosomal translocations and functional alterations involved. They are well done and informative. The chapters all include current references up through 1995, although the length of the reference lists varies substantially among them. The contributing authors are well recognized, and the volume is a valuable overview of the current state of knowledge in a topic of great relevance in understanding the bases for an important area of human disease. The preface is unusually informative in setting out the goals of the volume and the contents and relevance of the chapters that follow, and it would be a valuable addition to libraries and to the targeted cancer researchers and molecular geneticists.

3 Stars from Doody
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