Churchill's In Clinical Practice Series: Acute Coronary Syndromes

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Overview

This title, which contains contributions from Europe in addition to the USA and Canada, distills and organizes the maze of clinical data on the diagnosis, risk stratification, treatment, and prevention of acute coronary syndromes. The book discusses pragmatically how to treat NSTEMI and STEMI, looking at some of the oldest drugs available, such as aspirin, through to the new thrombin inhibitors, lytics and such like. The book flags up many of the developments in the fields of inflammation, infection, reversal of endothelial dysfunction, thrombolysis versus primary angioplasty and so forth, and presents the evidence to support the rapidly evolving guidelines.

• Unique design, comprising novel 3D effect artworks
• ‘Pull-out quotes' included in the margin to provide a novel means of highlighting key information
• Includes management algorithms to provide quick reference treatment pathways
• Includes Clinical Cases highlighting key issues in the main text
• Credible evidence-based sources - when possible, evidence base for practice by reference to primary research or international guidelines
• Bullet lists and short tables for clear presentation of key information
• Abbreviations lists
• Website addresses and other useful contact details

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Product Details

Meet the Author

Richard Katz MD, FACC was appointed the Director of the Division of Cardiology at the George Washington University in 1997. He has been involved in numerous research studies and has served as the principal investigator for a number of national clinical trials including CAST - Cardiac Arrhythmia Suppression Trial, PEACE -Prospective Evaluation of ACE inhibitors and BEST - Beta-blocker Evaluation of Survival Trial. He has presented his research experiences across the country at numerous conferences including those hosted by the American Heart Association and the American College of Cardiology. In addition, his research findings have been published in over 80 articles and more than 100 abstracts. Dr Katz has been visiting professor to both the Royal Brompton National Heart and Lung Hospital and the Hammersmith Hospital in London, UK. He is a fellow of the American College of Cardiology and served as their governor of the District of Columbia from 1997to 2000.He serves on the board of directors for the Larry King Cardiac Foundation and on the editorial boards of Cardiology Review and the British Journal of Cardiology. In addition, he is a reviewer for Circulation and the American Journal of Cardiology and a consultant for the National Institute of Health.

Henry Purcell MB, PhD, is Senior Fellow in Cardiology at The Royal Brompton Hospital in London. He lectures widely and has published many peer-reviewed research papers and abstracts. He was a member of the British Cardiac Society Working Group producing guidelines on management of patients with acute coronary syndromes without peristent ECG ST segment elevation (2001). He is co-editor of the British Journal of Cardiology and on several editorial boards and has co-edited the text Specialist Training in Cardiology, published by Elsevier/Mosby. He is also a reviewer for many international journals in cardiovascular medicine.

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Table of Contents

Foreword Professor Kim Fox

Definitions: epidemiology and prognosis

Pathophysiology
- plaque rupture
- inflammation and ACS
- platelets and the coagulation system

Diagnosis
- clinical signs and symptoms
- chest pain evaluation
- resting 12-lead ECG
- cardiac enzymes and biomarkers
- risk stratification
- inflammatory and other prognostic markers
- exercise testing
- radionuclide testing
- coronary angiography

Prevention of ACS

Current management
- site-based algorithms
- rationale for specific treatments
- oral antiplatelet therapies (aspirin and thienopyridines)
- anti-thrombin therapies
(heparin)
(low molecular weight heparin)
(direct thrombin inhibitors)

Intravenous anti-platelet therapy glycoprotein IIb/IIIa inhibitors

Anti-ischaemic therapies
- nitrates
- beta blockers
- calcium blockers
- nicorandil

Medical revascularisation

Disease modifying agents
- statins in ACS
- ACE inhibitors
- Do anti-infectives play a role?

Treatment of acute myocardial infarction (STEMI)

Clinical Cases
Appendix 1 – Drug tables
Appendix 2 – Useful websites and addresses
References
Index

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