×

Uh-oh, it looks like your Internet Explorer is out of date.

For a better shopping experience, please upgrade now.

Clinical and Translational Science: Principles of Human Research
     

Clinical and Translational Science: Principles of Human Research

by David Robertson, Gordon H. Williams
 

See All Formats & Editions

ISBN-10: 0123736390

ISBN-13: 9780123736390

Pub. Date: 12/15/2008

Publisher: Elsevier Science

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of

Overview

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.

Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science.

  • Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications
  • Contributions from international leaders provide insight into background and future understanding for clinical and translational science
  • Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Product Details

ISBN-13:
9780123736390
Publisher:
Elsevier Science
Publication date:
12/15/2008
Edition description:
New Edition
Pages:
600
Product dimensions:
8.80(w) x 11.00(h) x 1.60(d)

Table of Contents

Section I. Fundamental Principles

Chapter 1. Introduction to Clinical Research

Chapter 2. Patient-Oriented Research

Chapter 3. Clinical Trials

Chapter 4. Introduction to Epidemiology

Chapter 5. The Patient-Centered Outcomes Research Institute: Current Approach toFunding Clinical Research and Future Directions

Chapter 6. Health-Care Technology Assessment (HTA)

Chapter 7. Health Services Research: Translating Discovery and Research Into Practice andPolicy

Section II. Approaches

Chapter 8. Measurement of Biological Materials

Chapter 9. Imaging Tools in Clinical Research: Focus on Imaging Technologies

Chapter 10. Imaging Tools in Human Research: Focus on Image-Guided Intervention

Chapter 11. Nanotechnology in Clinical and Translational Research

Chapter 12. The Use of Questionnaires and Surveys

Chapter 13. Information Technology

Chapter 14. Principles of Biostatistics

Chapter 15. Good Clinical Practice and Good Laboratory Practice

Section III. Human Genetics

Chapter 16. Introduction to Human Genetics

Chapter 17. Epidemiologic and Population Genetic Studies

Chapter 18. Pharmacogenetics of Drug Metabolism

Chapter 19. Statistical Techniques for Genetic Analysis

Section IV. Human Pharmacology

Chapter 20. Introduction to Clinical Pharmacology

Chapter 21. Adverse Drug Events

Section V. Societal Context of Human Research

Chapter 22. Translating Science to the Bedside: The Innovation Pipeline

Chapter 23. Regulatory Environment

Chapter 24. Ethical Issues in Translational Research and Clinical Investigation

Chapter 25. Clinical Research in the Public Eye

Section VI. Research in Special Populations

Chapter 26. Research in Special Populations: Acute Illnesses; Critical Care; and SurgicalPatients

Chapter 27. Research in the Emergency Care Environment

Chapter 28. Psychiatric Disorders

Chapter 29. Research in Special Populations: Geriatrics

Chapter 30. Clinical Research in Neurology

Chapter 31. Research in Pediatrics

Chapter 32. Cancer as a Paradigm for Translational and Clinical Biomedical Research

Chapter 33. Maintaining an Emphasis on Rare Diseases With Research Initiatives and Resources at the National Center for Advancing Translational Sciences

Section VII. Infrastructure

Chapter 34. Clinical and Translational Science Infrastructure

Section VIII. Education, Training and Career Choices

Chapter 35. Education, Training and Career Choices: Training Basic, Clinical, and Translational Investigators

Chapter 36. A Stepwise Approach to a Career in Translational Research

Chapter 37. Physician Careers in the Pharmaceutical Industry

Section IX. Research in Academia

Chapter 38. Industry-Sponsored Clinical Research inAcademia

Chapter 39. Governmental Support of Research

Chapter 40. The Role of Nonprofit, Nongovernmental Funding in Support of Biomedical Research

Chapter 41. Modern Drug Discovery and Development

Chapter 42. Pharmaceutical and Biotechnology Sector Support of Research

Section X. Prospectus

Chapter 43. The Future of Clinical Research

Customer Reviews

Average Review:

Post to your social network

     

Most Helpful Customer Reviews

See all customer reviews