Clinical Applications of Mass Spectrometry: Methods and Protocols / Edition 1

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Overview

As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Prools, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical prools, and detailed notes on troubleshooting and avoiding known pitfalls.

Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Prools offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.

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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is a compilation of test protocols for mass spectrometry testing of clinically relevant analytes.
Purpose: The purpose is to provide a compendium of mass spectrometry protocols in recognition of its increasing use in clinical laboratories.
Audience: This book is intended for use by clinical laboratories using mass spectrometry. It would be extraordinarily useful for technical supervisors, clinical consultants, and testing personnel of clinical laboratory chemistry sections. It also would be of interest to laboratory medicine or pathology residents, clinical chemistry fellows, or laboratory directors who use this methodology in their laboratories.
Features: The editors are right on target with anticipating the need for this book, correctly identifying the rapid expansion of mass spectrometry use in the clinical laboratory and the need for associated protocols and method standardization. After the first introductory chapter, the remaining 51 chapters are standalone protocols for anything you might be tempted to quantify or identify using mass spectrometry (i.e., amino acids, drugs, vitamin D levels, steroids, inborn errors of metabolism, some antibiotics, etc.). Each chapter is basically a laboratory protocol easily adaptable to an individual laboratory. The chapters/protocols follow a standard format — clinical rationale for the assay, materials (with extensive tables of internal control materials as necessary), quality control, instrumentation, method, calculations, results interpretation, procedure notes, and references a la the CLSI recommended policy and procedure guidelines. This is a great book to have if you are considering implementing mass spectrometry in your laboratory or expanding your test menu — either should be relatively easy with these protocols in hand. This is a very welcome addition to the laboratory medicine field.
Assessment: This is a great compilation of mass spectrometry protocols for clinically useful analytes. Get it if you are considering implementing this method (so you know what you're getting into) or expanding your test menu (so you can readily adapt the protocols to your own setting).
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Product Details

  • ISBN-13: 9781607614586
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/14/2009
  • Series: Methods in Molecular Biology Series , #603
  • Edition description: 2010
  • Edition number: 1
  • Pages: 540
  • Product dimensions: 7.30 (w) x 10.20 (h) x 1.50 (d)

Table of Contents

1. The Evolution of Mass Spectrometry in the Clinical Laboratory

Catherine A. Hammett-Stabler and Uttam Garg

2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry

Nathalie Lepage and Susan Aucoin

3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism

Dennis J. Dietzen and Annette L. Weindel

4. Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS)

Josh Gunn, Scott Kriger, and Andrea R. Terrell

5. Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry

Ruth E. Winecker

6. Quantitation of Argatroban in Plasma using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS)

Ross J. Molinaro

7. Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)

Leonard L. Johnson and Uttam Garg

8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)

Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves

9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium

Stephanie J. Marin and Gwendolyn A. McMillin

10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS

Josh Gunn, Scott Kriger, and Andrea R. Terrell

11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS)

Jeff M. Knoblauch, David K. Scott, Laurie D. Smith, and Uttam Garg

12. Quantification of Busulfan in Plasma Uing Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

Marion L. Snyder and James C. Ritchie

13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)

C. Clinton Frazee III, Michael Kiscoan, and Uttam Garg

14. Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)

Steven W. Fleming, Amitava Dasgupta, and Uttam Garg

15. Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS)

Scott Kriger, Josh Gunn, and Andrea R. Terrell

16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS

Josh Gunn, Scott Kriger, and Andrea R. Terrell

17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine

Qin Sun and William E. O'Brien

18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS)

Judy Stone

19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry

Judy Stone

20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS

Mark M. Kushnir, Alan L. Rockwood, Bingfang Yue, and A. Wayne Meikle

21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry

Patricia M. Jones and Michael J. Bennett

22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)

Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves

23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS)

Bruno Casetta

24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS)

Ryan Allenbrand and Uttam Garg

25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH)

Ravinder J. Singh

26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC/MS)

David K. Scott, Kathleen Neville, and Uttam Garg

27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)

Gerry Huber and Uttam Garg

28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)

Sarah Thomas, Amanda Sutton, and Uttam Garg

29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

Ross J. Molinaro and James C. Ritchie

30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)

Timothy P. Rohrig, Megan Gamble, and Kim Cox

31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Denise M. Timko and Douglas F. Stickle

32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry

X. Kate Zhang, Carole S. Elbin, Frantisek Turecek, Ronald Scott, Wei-Lien Chuang, Joan M. Keutzer, and Michael Gelb

33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP)

Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman

34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy

Vikram S. Kumar, Terence Law, and Mark Kellogg

35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry

Jie Chen and Michael J. Bennett

36. Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography–Tandem Mass Spectrometry

Claudine Fasching and Jasbir Singh

37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry

Catherine A. Hammett-Stabler, Diane Ciuffetti Geis, James Ritchie, and Christine Papadea

38. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS/MS

Bingfang Yue, Mark M. Kushnir, Francis M. Urry, and Alan L. Rockwood

39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)

Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves

40. Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection

Tim Dahn, Josh Gunn, Scott Kriger, and Andrea R. Terrell

41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry

Patricia M. Jones and Michael J. Bennett

42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC/MS)

Stanley F. Lo, Velta Young, and William J. Rhead

43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry

Jie Chen and Michael J. Bennett

44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)

Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves

45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)

Angela M. Ferguson and Uttam Garg

46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS)

Magdalena Korecka and Leslie M. Shaw

47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS)

Keri J. Donaldson and Leslie M. Shaw

48. Analysis of Testosterone in Serum Using Mass Spectrometry

Robert L. Fitzgerald, Terrance L. Griffin, and David A. Herold

49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC/MS)

Judy Peat and Uttam Garg

50. Quantitation of 25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS/MS)

Ravinder J. Singh

51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)

Timothy P. Rohrig, Lydia A. Harryman, and Melissa C. Norton

52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)

Timothy P. Rohrig, Melissa C. Norton, and Lydia A. Harryman

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