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Clinical Applications of the Limulus Amoebocyte Lysate Test
     

Clinical Applications of the Limulus Amoebocyte Lysate Test

by Richard B. Prior
 
The primary focus of this book is to present the various clinical applications of the Limulus amoebocyte lysate (LAL) test for the detection of Gram-negative bacterial endotoxins. Using the clinical syndrome approach, it presents information from leading authorities pertaining to endotoxemia, meningitis, bacteriuria, gonorrhea, pyogenic arthritis, otitis media, ocular

Overview

The primary focus of this book is to present the various clinical applications of the Limulus amoebocyte lysate (LAL) test for the detection of Gram-negative bacterial endotoxins. Using the clinical syndrome approach, it presents information from leading authorities pertaining to endotoxemia, meningitis, bacteriuria, gonorrhea, pyogenic arthritis, otitis media, ocular infections, peritonitis and perforation in blunt abdominal trauma, allied medical applications including hemodialysis water testing, and veterinary applications. This volume includes discussions on such topics as bacterial endotoxins and their clinical significance, the horseshoe crab and the various methodologies used in the LAL test, and the role of the Food and Drug Administration in the regulation of the LAL test. This publication is an absolute must for every physician, medical student, nurse, pathologist, toxicologist, microbiologist, public health official, and laboratory technician, as well as everyone involved in the teaching, evaluation, management, and treatment of clinical situations involving Gram-negative bacteria.

Editorial Reviews

Booknews
Explains the clinical diagnostic use of the LAL test to detect Gram- negative bacterial endotoxins, the presence of which is associated with chronic diseases, though the exact role is still unknown. The early unreliability of the quick and inexpensive test has been addressed by standards of methodology and of the preparation of the lysate, which is now commercially available. Topics include a review of the clinical syndrome, the background and relative advantages of evaluation methods, utility and predictive values, and current trends. Other chapters review endotoxins and their clinical significance, describe the role of FDA regulation of the test, survey its veterinary and pharmaceutical applications, and introduce the little horseshoe crab, from whom we learned the trick. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9780849362095
Publisher:
Taylor & Francis
Publication date:
08/15/1990
Pages:
192
Product dimensions:
7.20(w) x 10.20(h) x 0.60(d)

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