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From The CriticsReviewer: Bradley R. Cutler, MD (Edward Hospital and Health Services)
Description: The Collaborative Depression Study (CDS) is among the most significant psychiatric studies ever undertaken. The 1950s and l960s brought a newfound excitement to psychiatry with new theories of the pathophysiology of depression and the mechanism of action of antidepressants. To better understand the psychobiology of depression, the CDS began following patients in the 1970s. The initial protocol called for patients to be followed for two years. During the course of the study, however, it became clear that depression had a much more severe clinical course than previously described. These findings caused the investigators to extend the length of the study, and participants were studied for a full 31 years. This book discusses the fundamental findings from that study.
Purpose: The purpose is to provide a summary of the key findings of the CDS.
Audience: It is targeted for healthcare professionals interested in understanding the phenomenology, diagnosis, genetics, longitudinal course, and treatment of patients with depression and bipolar disorder.
Features: Chapter 1 is an introduction to the CDS and a discussion of the topics the book covers. Chapter 2 reviews in detail assessments, procedures, and study design. Chapters 3 and 4 present a dimensional approach to unipolar depression and bipolar disorder, respectively. Chapter 5 examines the risk factors for suicide. Subsequent chapters discuss the presence of psychosis, mania, hypomania, mania, substance use, anxiety, and family history in mood disorders. The clinical course and treatment of mood disorders are also examined in detail. Finally, chapter 16 summarizes contributions of the CDS to the DSM-5. Each chapter ends with a section on clinical implications followed by a list of references.
Assessment: The CDS is without a doubt one of the longest and most intensive psychiatric studies ever conducted. At least 285 empirical reports have been published based on CDS findings, and the CDS has led to a rethinking of the terminology of mood disorders and a new appreciation of their devastating, long-term course. A study of such extraordinary magnitude and paramount importance demands a book to summarize its key findings. This is that book.