Clinical Immunology and Serology: A Laboratory Perspective / Edition 3

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I love the way the book is organized.”—Wendy Miller, MS, CLS(NSA), MT(ASCP)SI

“I enthusiastically support the author’s approach…I think this is a very valuable text…”—Stephen M. Johnson, MS, MT (ASCP)

Completely updated to include new information about the immune system and new treatments for immunological diseases! This practical introduction to clinical immunology covers all of the essential theoretical principles and the serology techniques most commonly used in the laboratory. Structured into easy-to-read, student-friendly sections, the 3rd Edition focuses on the direct application of theory to clinical laboratory practice.

With questions by Maribeth L. Flaws, Ph.D., SM(ASCP)SI, Rush University Medical Center, Chicago, Illinois and Christine Dorresteyn Stevens, EdD, MT(ASCP), Western Carolina University, Cullowhee, North Carolina

The book contains black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: Valerie L Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is the second edition of a comprehensive laboratory textbook of clinical immunology and serology.
Purpose: The purpose is to provide a comprehensive reference for laboratory evaluations of immunological diseases and serological tests. This edition expands on the first one by including new information, additional illustrations, and case studies for each subject matter.
Audience: This book would be very useful for clinical laboratory scientists (CLS) in training or early in their practicing career. This book would also be very helpful as the course textbook for anyone teaching CLS students or for those performing such testing in their everyday practice (e.g., CLSs, pathologists, laboratory medicine residents, internal medicine practitioners).
Features: This one-inch thick paperback book has 23 chapters. The first six cover the theoretical basis of immunology, followed by five chapters discussing basic laboratory test methodologies for immunological disorders or serology, another six chapters on specific immunologic disorders, and finally five chapters on commonly performed serological tests. I spent some time on the chapters on immunological disorders because this field is so rapidly evolving. The descriptions of various diseases are concise yet complete, and nicely complemented with discussions of the corresponding available tests. Of note, the old "LE prep" test, a nonspecific test historically used as an adjunct for diagnosing systemic lupus erythematosus (SLE), is not even mentioned - one of many examples thatthis book accurately reflects current and best laboratory practice! Many of the chapters are followed by an "Exercise" for the interested reader, followed by review questions that nicely capture the key learning points. This book is an excellent reference for anyone learning or practicing clinical immunology or serology, based on its emphasis on evidence-based good laboratory practice.
Assessment: This is a really nice reference to have handy in a clinical immunology or serology lab, and is a MUST for any CLS training program — students and instructors alike.
An introductory text primarily for clinical laboratory science students at the second- and fourth-year levels. Combines theoretical principles with practical information on serological techniques commonly used in the clinical lab. Sections cover the nature of the immune system; basic immunologic procedures; immune disorders; and serological diagnosis of infectious diseases. Annotation c. Book News, Inc., Portland, OR (

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780803618145
  • Publisher: F. A. Davis Company
  • Publication date: 8/31/2009
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 480
  • Sales rank: 268,002
  • Product dimensions: 8.40 (w) x 10.70 (h) x 1.00 (d)

Table of Contents

  1. I. Nature Of The Immune System
    1. Introduction and Natural Immunity
    2. Lymphoid System
    3. Nature of Antigens and Major Histocompatibility Complex
    4. Antibody Structure and Function
    5. Cytokines
    6. Complement System

  2. II. Basic Immunological Procedures
    1. Safety and Specimen Preparation
    2. Precipitation Reactions
    3. Agglutination
    4. Labeled Immunoassays
    5. Molecular Techniques
    6. Flow Cytometry and Laboratory Automation

  3. III. Immune Disorders.
    1. Hypersensitivity
    2. Autoimmunity
    3. Immunoproliferative Diseases
    4. Immunodeficiency Disease
    5. Transplantation Immunology
    6. Tumor Immunology

  4. IV. Serological Diagnosis Of Infectious Disease.
    1. Serologic and Molecular Detection of Bacterial Infections
    2. Serology of Parasitic and Fungal Infections
    3. Spirochete Diseases
    4. Serology and Molecular Detection of Viral Infections
    5. Laboratory Diagnosis of HIV Infection


Answer Key


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