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Clinical Management of Bone and Joint Pain

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Provide your patients with effective treatment for their pain

Clinical Management of Bone and Joint Pain is a comprehensive, practical guide to specific pharmacological and non-pharmacological treatments of bone and joint pain. This comprehensive resource provides non-pain management specialists with information that enables them to provide their patients with logical, effective treatment options. It’s an invaluable professional tool for rheumatologists, orthopedic physicians ...

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2007 Hardcover Very good 8vo, hardcover. No dj. Vg+ condition. Slight rubbing to covers; contents clean, unread. xvi, 418 p., illus. (some color).

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Overview

Provide your patients with effective treatment for their pain

Clinical Management of Bone and Joint Pain is a comprehensive, practical guide to specific pharmacological and non-pharmacological treatments of bone and joint pain. This comprehensive resource provides non-pain management specialists with information that enables them to provide their patients with logical, effective treatment options. It’s an invaluable professional tool for rheumatologists, orthopedic physicians and surgeons, sports injury physicians, and general practitioners.

Remarkable advances have been made in recent years in the management of a wide range of bone and joint diseases. Clinical Management of Bone and Joint Pain offers medical professionals working on the frontline of clinical medicine and surgery with practical options for the treatment of pain. The book includes individual accounts of specific pharmacological and non-pharmacological treatments; an inclusive range of treatments for specific conditions; suggested doses for treatment outlines; insights into the mechanisms of pain arising from bones and joints; and an outline of pain treatment options. Each chapter includes a summary of the treatment described and suggestions for its practical use.

Topics examined in Clinical Management of Bone and Joint Pain include:

  • basic pain mechanisms
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • the pain-relieving effects of capsaicin
  • the topical applications of glyceryl trinitrate (GTN)
  • the use of topical analgesics
  • intraarticular injections in the treatment of joint pain
  • using peripheral nerves block in pain management
  • using opioids in pain management
  • acetaminophen
  • glucosamine
  • glucocorticoids
  • hyaluronic acid in the treatment of joint pain
  • anti-rheumatic drugs
  • physical therapy
  • acupuncture
  • botulinum toxins
  • radiopharmaceuticals as a treatment option for advanced cancer pain
  • muscle relaxant drugs
  • and much more
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Product Details

Meet the Author

Gary McCleane, MD, is a practicing consultant in pain management in Northern Ireland. His interests include the use of cholecystokinin antagonists in pain management and the use of tricyclic antidepressants and topical analgesics. He has published a number of studies examining the analgesic effect of CCK antagonists, capsaicin, topical TCAs, and anti-epileptics, including gabapentin, lamotrigine, phenytoin, fosphenytoin, and the novel anti-epileptic SPM 927. He has published a number of review papers examining current options for the treatment of neuropathic pain and cholecystokinin antagonists in human pain management.

Howard Smith, MD, is Academic Director of Pain Management in the Department of Anesthesiology at Albany Medical College, Albany, New York. He has also served on the faculty at the University of Pittsburgh School of Medicine and Harvard Medical School as Director of Pain Medicine - Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania and Director of Cancer Pain - Beth Israel Deaconess Medical Center, Boston, Massachusetts, respectively. Dr. Smith also served as the Director of Pain Management and Director of Pain Fellowship at the Albany Medical College/Albany Medical Center Hospital. He is editor of the Journal of Neuropathic Pain & Symptom Palliation and the Journal of Cancer Pain & Symptom Palliation and is an editorial board member of the American Journal of Hospice and Palliative Care. Dr. Smith is the author of the forthcoming books Drugs for Pain and A Women's Guide to Ending Pain.

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Table of Contents

  • About the Editors
  • Contributors
  • Introduction (Gary McCleane)
  • PART I
  • Chapter 1. Basic Pain Mechanisms (Jana Sawynok)
  • Introduction
  • Joint Innervation and Activation
  • Models of Inflammation
  • Pain in Arthritis
  • Conclusion
  • Chapter 2. The Physiology and Basic Science of Bone and Joints (Helen Cohen and David Blake)
  • Skeletal Developmental Biology
  • Molecular Genetics
  • Mature Joint Tissues
  • Mature Bone
  • Gross Structure
  • Microscopic Structure
  • Mature Cartilage
  • Synovium
  • Synovial Fluid
  • Tendons
  • Ligaments
  • Bursae
  • Circulation
  • Joint Stability
  • Synovium and Inflammation
  • Summary
  • PART II
  • Chapter 3. NSAIDs for Painful Bone and Joint Conditions (Jennifer A. Elliott and Howard S. Smith)
  • Introduction
  • Mechanisms of Action of NSAIDs
  • Gastrointestinal Effects of NSAIDs
  • Renal Effects of NSAIDs
  • Platelet Effects of NSAIDs
  • Central Nervous System Effects of NSAIDs
  • Other NSAID Effects
  • Classification of NSAIDs
  • Potential Adverse Drug Interactions with NSAIDs
  • Conclusion
  • Chapter 4. Capsaicin (Gary McCleane)
  • Clinical Use of Capsaicin
  • Side Effects of Topical Capsaicin Application
  • Unanswered Questions Regarding Use of Capsaicin
  • Suggested Clinical Use of Capsaicin
  • Strategies to Reduce Discomfort of Application of Capsaicin
  • Chapter 5. Topical Nitrates (Gary McCleane)
  • Mode of Action of Topical Nitrates When Used As Analgesics
  • Human Experimental Pain
  • Studies Suggesting an Analgesic Effect When Nitrates Are Used Topically
  • Effect of Topical Glyceryl Trinitrate on Inflammation
  • Effect of Topical Nitrate on Analgesic Effect of Opioids
  • Issues with the Use of Transdermal Nitrates
  • Glyceryl Trinitrate Formulations
  • Side Effects on Topical Glyceryl Trinitrate
  • Suggested Clinical Use
  • Chapter 6. Topical Analgesic Options (Charles Argoff)
  • Topical versus Transdermal
  • Choice of Agents
  • Other Uses of Topical Analgesics
  • Chapter 7A. Intra-Articular Injections (William Lavelle, Elizabeth Demers, and Lori Lavelle)
  • History of Intra-Articular Steroid Injections
  • Mechanism of Action of Intra-Articular Steroid Injections
  • Selected Injection Techniques
  • Chapter 7B. Nerve Blocks (Elizabeth Demers, William Lavelle, and Lori Lavelle)
  • Introduction
  • Upper Extremity Blocks
  • Lower Extremity Nerve Blocks
  • Techniques for Localization of a Nerve
  • Chapter 8. Opioids (Gary McCleane)
  • Pain and Its Responsiveness to Opioids
  • Effect of Peripheral Application of Opioids For Acute Pain
  • Codeine
  • Dihydrocodeine
  • Tramadol
  • Meperidine
  • Propoxyphene
  • Pentazocine
  • Morphine
  • Diamorphine \
  • Hydromorphone
  • Methadone
  • Fentanyl
  • Buprenorphine
  • Oxycodone
  • Side Effects of Opioid Analgesics
  • Conclusions
  • Chapter 9. Acetaminophen (Nisar Soomro)
  • Structure
  • Mechanism of Action
  • Absorption
  • Metabolism
  • Toxicity
  • Antidote
  • Indications
  • Formulations
  • Dose
  • Arthritic Pain
  • Interactions
  • Conclusions
  • Chapter 10. Glucosamine (William Lavelle, Elizabeth Demers, and Lori Lavelle)
  • History
  • Mechanism of Action
  • Clinical Trials
  • Safety and Adverse Reactions
  • Discussion
  • Chapter 11. Clinical Pharmacology of Glucocorticoids (Muhammad A. Munir and Jun-Ming Zhang)
  • Introduction
  • Corticosteroids
  • Pharmacodynamics
  • Pharmacokinetics
  • Clinical Pharmacology
  • Clinical Summary
  • Chapter 12. Hyaluronic Acid (William Lavelle, Elizabeth Demers, and Lori Lavelle)
  • History
  • Mechanism of Action
  • Clinical Trials
  • Safety and Adverse Reactions
  • Discussion
  • Chapter 13. Disease-Modifying Antirheumatic Drugs (Lori Lavelle, William Lavelle, and Elizabeth Demers)
  • Introduction
  • Antimalarials
  • Glucocorticoids
  • Methotrexate
  • Leflunomide
  • Sulfasalazine
  • Azathiprine
  • Cyclosporine
  • D-Penicillamine
  • Cyclophosphamide
  • Mycophenolate Mofetil
  • Gold
  • Biologic Agents
  • Chapter 14. Physical Therapy (Denis Martin)
  • Introduction
  • Function
  • Addressing Impairment: A Biomedical Application of Physical Therapy
  • Addressing Activity and Participation: A Biopsychosocial Application of Physical Therapy
  • Conclusion
  • Chapter 15. Acupuncture (Gira Patel)
  • Introduction
  • How Acupuncture Works
  • History and Philosophy
  • Treatment Principles
  • Conditions Treated
  • Chapter 16. Botulinum Toxin (Charles Argoff)
  • Introduction
  • The Current USFDA-Approved Uses of the Botulinum Toxins
  • The Use of the Botulinum Toxins for the Treatment of Chronic Headache
  • The Use of Botulinum Toxin in the Management of Musculoskeletal Pain
  • The Use of Botulinum Toxin in the Management of Neuropathic Pain and Other Painful Conditions
  • Chapter 17. Radiopharmaceuticals (Rahul Parikh and Howard S. Smith)
  • Introduction
  • Pathophysiology of Painful Osseous Metastases
  • Current Treatment Options
  • Radiopharmaceutical Agents—Overview
  • Radiopharmaceutical Agents
  • Investigational Radiopharmaceuticals
  • Patient Selection Criteria and Treatment Guidelines
  • Administration of Radiopharmaceuticals and Follow-Up
  • Future Work
  • Conclusion
  • Chapter 18. Muscle Relaxants (Gary McCleane)
  • Baclofen
  • Benzodiazepines
  • Carisoprodol
  • Cyclobenzaprine
  • Dantrolene
  • Metaxalone
  • Methocarbamol
  • Orphenadrine
  • Tizanadine
  • Miscellaneous
  • Suggested Clinical Use of Muscle Relaxant Drugs
  • Chapter 19. Other Options (Howard S. Smith and Mark Guerdan)
  • NSAIDs
  • Biosynthetic Options
  • The Future
  • Summary
  • PART III
  • Chapter 20. Joint Pain (Gary McCleane)
  • Monoarticular Pain
  • Polyarticular Options
  • Chapter 21. Fracture Pain (Gary McCleane)
  • Is Fracture Pain Adequately Treated?
  • Pharmacological Options
  • Treatment of Specific Fractures
  • Chapter 22. Pathophysiology and Analgesic Approaches to Painful Bone Metastasis (Howard S. Smith and Jennifer A. Elliott)
  • Introduction
  • Pathophysiology of Bone Resorption
  • Osteoclast Osteolysis
  • Modulation of Osteoclastic Activity Modulates Nociception
  • Chapter 23. Pain Arising from Tendons and Tendon Sheaths (Gary McCleane)
  • Topical Options
  • Injections
  • Oral Options
  • Others
  • Suggested Treatment for Tendon-Related Pain
  • Chapter 24. When Is Pain Felt Over a Bone or Joint, Not Bone or Joint Pain? (Gary McCleane)
  • Radiated Pain/Neuropathic Pain
  • Referred Pain
  • Complex Regional Pain Syndrome
  • Aid to Diagnosis
  • Index
  • Reference Notes Included
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