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Doody's Review ServiceReviewer: Alyson Myers, MD (North Shore - LIJ Hofstra School of Medicine)
Description: This is a reference for physicians of all specialties to acquire a better understanding of the potential dangers of combining medications. Five years ago, this book was published as a concise guide, but the authors felt that the information was so dense that it should become a clinical manual.
Purpose: The purpose is to explore the numerous systems used in the metabolism of endogenous and exogenous compounds. In doing so, it aids physicians in promoting good patient care and understanding a patient's response to treatment. Many of the drugs discussed are prescribed for a variety of ailments and by a variety of specialists or subspecialists, so the book accomplishes its goal. An example of this is the two-fold increase of metoprolol's metabolism when used with cymbalta. This information is useful to psychiatrists, internists, rheumatologists, and cardiologists, as they all may have a patient on this combination of medications.
Audience: Practitioners or residents in any field can benefit from the information in this book.
Features: The structure of the book makes it easy read. The three main sections include a review of pharmacology, a review of the p450 system, and a discussion of common medications used in a variety of specialties such as neurology or obstetrics/gynecology. Numerous tables or diagrams demonstrate these topics. At the end of the chapters on the p450 system, numerous case examples further reinforce the potential of drug-drug interaction.
Assessment: As a resident physician in a combined internal medicine/psychiatry residency program, I found this book extremely helpful. It serves as a great source when caring for patients with multiple medical problems coupled with mental illness. The large amount of information in this book justifies its change from a concise guide to a clinical manual.