Clinical Manual of Drug Interaction Principles for Medical Practice [NOOK Book]

Overview

Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population...

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Clinical Manual of Drug Interaction Principles for Medical Practice

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Overview

Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print.

Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field.

The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility: • The book boasts the very latest information in the area of drug metabolism, transport, and interaction.• The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms.• The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors.

All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.

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Editorial Reviews

Doody's Review Service
Reviewer: Alyson Myers, MD (North Shore - LIJ Hofstra School of Medicine)
Description: This is a reference for physicians of all specialties to acquire a better understanding of the potential dangers of combining medications. Five years ago, this book was published as a concise guide, but the authors felt that the information was so dense that it should become a clinical manual.
Purpose: The purpose is to explore the numerous systems used in the metabolism of endogenous and exogenous compounds. In doing so, it aids physicians in promoting good patient care and understanding a patient's response to treatment. Many of the drugs discussed are prescribed for a variety of ailments and by a variety of specialists or subspecialists, so the book accomplishes its goal. An example of this is the two-fold increase of metoprolol's metabolism when used with cymbalta. This information is useful to psychiatrists, internists, rheumatologists, and cardiologists, as they all may have a patient on this combination of medications.
Audience: Practitioners or residents in any field can benefit from the information in this book.
Features: The structure of the book makes it easy read. The three main sections include a review of pharmacology, a review of the p450 system, and a discussion of common medications used in a variety of specialties such as neurology or obstetrics/gynecology. Numerous tables or diagrams demonstrate these topics. At the end of the chapters on the p450 system, numerous case examples further reinforce the potential of drug-drug interaction.
Assessment: As a resident physician in a combined internal medicine/psychiatry residency program, I found this book extremely helpful. It serves as a great source when caring for patients with multiple medical problems coupled with mental illness. The large amount of information in this book justifies its change from a concise guide to a clinical manual.
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Product Details

  • ISBN-13: 9781585628926
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 6/3/2009
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 608
  • Sales rank: 1,219,689
  • Product dimensions: 0.55 (w) x 0.82 (h) x 0.10 (d)
  • File size: 9 MB

Meet the Author

Gary H. Wynn, M.D., is Staff Psychiatrist at the Walter Reed Army Medical Center, in Washington, D.C., and Assistant Professor, Uniformed Services University School of Medicine in Bethesda, Maryland.

Jessica R. Oesterheld, M.D., is Acting Director of the Spurwink Department of Psychiatry, at the Maine Medical Center, and Clinical Associate Professor at the University of Vermont College of Medicine in Burlington, Vermont.

Kelly L. Cozza, M.D., FAPM, FAPA, is Associate Professor at Uniformed Services University School of Medicine in Bethesda, Maryland, and Consultant in the Department of Psychiatry at Walter Reed Army Medical Center in Washington, D.C.

Scott C. Armstrong, M.D., DFAPA, FAPM, is Medical Director of Tuality Center for Geriatric Psychiatry, and Associate Clinical Professor of Psychiatry at Oregon Health and Science University in Forest Grove, Oregon.

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Table of Contents

Preface. Acknowledgments. Part I: Introduction and Basic Pharmacology of Metabolic Drug Interactions. Introduction to drug interactions and to this clinical manual. Definitions and phase I metabolism. Metabolism in depth: phase II. Transporters. Part II: P450 Enzymes. 2D6. 3A4. 1A2. 2C9. 2C19. 2E1. 2A6, 2B6, and 2C8. Part III: Drug Interactions by Medical Specialty. Gynecology: oral contraceptives. Internal medicine. Infectious diseases. Neurology. Oncology. Pain management I: nonnarcotic analgesics. Pain management II: narcotic analgesics. Psychiatry. Transplant surgery and rheumatology: immunopsuppressants. Part IV: Practical Matters. Guidelines. Medicolegal implications of drug--drug interactions. How to retrieve and review the literature. Appendix: tables of drug interaction pharmacokinetics. Index.

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