Clinical Mr Neuroimaging: Diffusion, Perfusion and Spectroscopy

Overview

The physiological magnetic resonance techniques of diffusion imaging, perfusion imaging and spectroscopy offer insights into brain structure, function and metabolism. Until recently, they were mainly applied within the realm of medical research, but with their increasing availability on clinical MRI machines, they are now coming into clinical practice for the evaluation of neuropathology in individual patients. This book provides the reader with a thorough treatment of the underlying physical principles of each ...
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Overview

The physiological magnetic resonance techniques of diffusion imaging, perfusion imaging and spectroscopy offer insights into brain structure, function and metabolism. Until recently, they were mainly applied within the realm of medical research, but with their increasing availability on clinical MRI machines, they are now coming into clinical practice for the evaluation of neuropathology in individual patients. This book provides the reader with a thorough treatment of the underlying physical principles of each of these methods, as well as a comprehensive review of their clinical applications. Topics covered include single- and multiple-voxel MRS techniques, MR perfusion based on both arterial spin labelling and dynamic bolus tracking approaches, and diffusion-weighted imaging, including techniques for mapping brain white matter fiber bundles. Clinical applications are reviewed in depth for each technique, with case reports included throughout the book. Attention is also drawn to possible artifacts and pitfalls associated with these techniques.
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Editorial Reviews

From The Critics
Reviewer: Robert James Bert, M.D., Ph.D.(University of Colorado Health Sciences Center)
Description: This book presents basic physic principals, basic mathematical principals and contemporary clinical applications of diffusion and perfusion MR imaging and MR spectroscopy. Its illustrations are well chosen to instruct the reader not only in the principals of these techniques, but also in their clinical applications.
Purpose: The author's foreword states that the purpose of this book is to create a reference for perfusion MRI, diffusion MRI and MR spectroscopy such that these techniques can be widely applied for routine use in clinical practice. Such a book is long overdue in our profession. In my opinion, this book accomplishes this goal.
Audience: While it was not explicitly stated, I believe it was the intent of the authors that this book was designed, primarily, for the practicing neuroradiologist. In my judgment, this would be the correct audience for this book. It would also be an appropriate text for neuroradiology fellows, especially in their second year. There are multiple true authors, often more than one for a given chapter. The authors are well chosen for most, if not all, chapters.
Features: "This book provides an introduction to the mathematics, physics and clinical applications of current commercially-available diffusion MRI, perfusion MRI and MR spectroscopy packages. The book illustrates the application of these techniques in aiding diagnosis of a broad range of pathologic processes. An excellent feature of this book is the appropriate number and quality of illustrating examples. The color figures liven readablity. The number of presented spectrographs illustrating pathology is superior to most other currently available texts. One drawback of this text is the number of typographical and grammatical errors. Careful editing appears to have been sacrificed. These errors are distracting and unnecessarily degrade the quality of the reading experience."
Assessment: This is a long overdue text that clarifies and simplifies the application of contemporary MR diffusion imaging (especially diffusion tensor imaging and white matter tractography), MR perfusion imaging and MR spectroscopy. Its greatest value is its comprehensive treatment of the theory of these imaging methods without resorting to advanced mathematical descriptions that would be beyond the level of many practicing physicians. I have not seen a comparable text on the market. However, the editing of the text is suboptimal with respect to spelling, typographical accuracy and grammar.
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Product Details

  • ISBN-13: 9780521824576
  • Publisher: Cambridge University Press
  • Publication date: 12/28/2004
  • Pages: 852
  • Product dimensions: 8.62 (w) x 10.87 (h) x 1.81 (d)

Meet the Author

Jonathan Gillard's research interests have centred on MR angiographic techniques. He is an author of over 50 peer reviewed publications and a journal reviewer for many publications.

Adam Waldman's main research interests are in clinical psychological imaging of neurodegenerative diseases and brain tumours. He has published widely and contributed to several textbooks.

Peter Barker has focussed his research career on the development of magnetic resonance spectroscopy techniques for the study of human brain metabolism and diagnosis of neurological disease. He is an author of over 100 peer reviewed publications, and a frequent journal reviewer.

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Table of Contents

Foreword Jonathan Gillard, Adam Waldman and Peter Barker; Introduction Nick Bryan; 1. Fundamentals of MR spectroscopy Peter Barker; 2. Quantification and analysis in MR spectroscopy Thomas Ernst; 3. Artifacts and pitfalls in MR spectroscopy Ralph Hurd; 4. Fundamentals of diffusion MR imaging Derek Jones; 5. MR tractography using diffusion tensor MR imaging Susumu Mori and Peter van Zijl; 6. Artifacts and pitfalls in diffusion MR imaging Martin Koch and David Norris; 7. Cerebral perfusion imaging by exogenous contrast agents Leif Ostergaard; 8. MRI detection of regional blood flow using arterial spin labeling Alan Koretsky, Lalith Talagala, Shella Keilholz and Afonso Silva; 9. Artifacts and pitfalls in perfusion MR imaging Fernando Calamante; 10. Cerebrovascular disease - overview Brian Tress; 11. MR spectroscopy in stroke Peter Barker and Jonathan Gillard; 12. Diffusion and perfusion MR in stroke Joanna Wardlaw; 13. Arterial spin labeling in stroke John Detre and Jyongjiong Wang; 14. Magnetic resonance diffusion tensor imaging in stroke Pamela Schaefer, Luca Roccatagliata and Gilberto Gonzalez; 15. MR spectroscopy in severe obstructive carotid artery disease Jeroen van der Grond and Dirk Rutgers; 16. Perfusion and diffusion imaging in chronic carotid disease Iain Wilkinson; 17. Imaging migraine pathogenesis Mike Welch; 18. Adult neoplasia: overview Tom Mikkelsen; 19. MR spectroscopy of brain tumors in adults Jeffry Alger; 20. Diffusion MR imaging in adult neoplasia Brian Ross, Brad Moffat and Thomas Chenevert; 21. Perfusion MR imaging in adult neoplasia Alan Jackson; 22. Physiological imaging in infection, inflammation and demyelination: overview Robert Zimmerman; 23. MR spectroscopy in intracranial infection Rakesh Gupta and Monika Garg; 24. The role of diffusion-weighted imaging in intracranial infection Christopher Fillipi; 25. MR spectroscopy in demyelination and inflammation Gioacchino Tedeschi and Simona Bonavita; 26. Diffusion imaging in demyelination and inflammation Massimo Filippi and Marco Rovaris; 27. Physiological MR to evaluate HIV-associated brain disorders Linda Chang and Thomas Ernst; 28. Seizure disorders: overview Thomas Henry; 29. MR spectroscopy in seizure disorders Graeme Jackson, Regula Brielmann and Mark Wellard; 30. Diffusion and perfusion MR imaging in seizure disorders Konstantinos Arfanakis and Bruce Hermann; 31. Psychiatric and neurodegenerative disease: overview Adam Waldman; 32. MR spectroscopy in psychiatry John Port; 33. Diffusion MR imaging in psychiatry and aging Adolf Pfefferbaum, Edith Sullivan and Elfar Adalsteinsson; 34. MR spectroscopy in aging and dementia Clifford Jack and Kejal Kantarci; 35. MR spectroscopy in neurodegeneration Charles Davie; 36. Potential role of MR spectroscopy, diffusion weighted/diffusion tensor imaging and perfusion weighted imaging in traumatic brain injury: overview John Pickard; 37. MR spectroscopy in traumatic brain injury William Brooks; 38. Diffusion- and perfusion-weighted MR imaging in head injury David Menon and Peter Bradley; 39. Physiological MR of the pediatric brain: overview Elias Melhem and Xavier Golay; 40. Physiological MRI of normal development and developmental delay A. James Barkovich, Dan Vigneron and Pratik Mukherjee; 41. MR spectroscopy of hypoxic brain injury Brian Ross, Cathleen Enriquez and Alexander Lin; 42. The role of diffusion and perfusion weighted brain imaging in neonatology Mary Rutherford; 43. Physiological MR of pediatric brain tumors Jill Hunter; 44. Physiological MRI techniques and pediatric stroke W. Kling Chong, V. Cionini and Dawn Saunders; 45. MR spectroscopy in pediatric white matter disease Folker Hanefeld, Knut Brockman and Peter Dechent; 46. MR spectroscopy of inborn errors of metabolism Alberto Bizzi, Marianna Bugiani and Ugo Danesi.

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